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Atad5 ATPase family, AAA domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 237877, updated on 8-Feb-2024

Summary

Official Symbol
Atad5provided by MGI
Official Full Name
ATPase family, AAA domain containing 5provided by MGI
Primary source
MGI:MGI:2442925
See related
Ensembl:ENSMUSG00000017550 AllianceGenome:MGI:2442925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm17; FRAG1; C130052G03Rik
Summary
Predicted to enable DNA binding activity and DNA clamp unloader activity. Involved in cell population proliferation; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and nuclear DNA replication. Acts upstream of or within several processes, including intracellular signal transduction; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and positive regulation of B cell activation. Located in nucleus. Is expressed in liver; metanephros; midbrain ventricular layer; renal cortex; and telencephalon ventricular layer. Orthologous to human ATAD5 (ATPase family AAA domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 5.8), CNS E11.5 (RPKM 5.5) and 14 other tissues See more
Orthologs
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Genomic context

See Atad5 in Genome Data Viewer
Location:
11 B5; 11 47.48 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (79980205..80026623)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80089379..80135797)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SUZ12 polycomb repressive complex 2 subunit Neighboring gene STARR-positive B cell enhancer ABC_E9368 Neighboring gene cytokine receptor-like factor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:79881110-79881263 Neighboring gene STARR-seq mESC enhancer starr_30136 Neighboring gene STARR-seq mESC enhancer starr_30137 Neighboring gene STARR-seq mESC enhancer starr_30138 Neighboring gene transcription elongation factor, mitochondrial Neighboring gene ArfGAP with dual PH domains 2, opposite strand Neighboring gene ArfGAP with dual PH domains 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • FLJ12735

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA clamp unloader activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA clamp unloader activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of isotype switching IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of nucleic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell cycle G2/M phase transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of mitotic cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Elg1 RFC-like complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATPase family AAA domain-containing protein 5
Names
chromosome fragility associated gene 1
chromosome fragility-associated gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029856.2NP_001025027.1  ATPase family AAA domain-containing protein 5

    See identical proteins and their annotated locations for NP_001025027.1

    Status: VALIDATED

    Source sequence(s)
    AL591113, AL663057, AL672178
    Consensus CDS
    CCDS25127.1
    UniProtKB/Swiss-Prot
    Q3TMG5, Q3UW85, Q3V306, Q3V3T9, Q4QY64, Q5SSK4, Q8BUH4, Q8CGG7
    UniProtKB/TrEMBL
    B2RUJ4
    Related
    ENSMUSP00000017694.6, ENSMUST00000017694.7
    Conserved Domains (1) summary
    cl21455
    Location:11151160
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    79980205..80026623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533234.4XP_006533297.1  ATPase family AAA domain-containing protein 5 isoform X3

    Conserved Domains (1) summary
    PRK04195
    Location:10361154
    PRK04195; replication factor C large subunit; Provisional
  2. XM_006533233.3XP_006533296.1  ATPase family AAA domain-containing protein 5 isoform X2

    Conserved Domains (1) summary
    PRK04195
    Location:10361154
    PRK04195; replication factor C large subunit; Provisional
  3. XM_006533232.4XP_006533295.1  ATPase family AAA domain-containing protein 5 isoform X1

    UniProtKB/TrEMBL
    B2RUJ4, Z4YKQ9
    Related
    ENSMUSP00000103874.2, ENSMUST00000108239.7
    Conserved Domains (1) summary
    PRK04195
    Location:10361151
    PRK04195; replication factor C large subunit; Provisional
  4. XM_011248989.4XP_011247291.1  ATPase family AAA domain-containing protein 5 isoform X4

    Conserved Domains (1) summary
    PRK04195
    Location:398516
    PRK04195; replication factor C large subunit; Provisional
  5. XM_017314529.2XP_017170018.1  ATPase family AAA domain-containing protein 5 isoform X5

    Related
    ENSMUST00000151815.8
    Conserved Domains (1) summary
    PRK04195
    Location:177295
    PRK04195; replication factor C large subunit; Provisional

RNA

  1. XR_004936950.1 RNA Sequence

  2. XR_001780002.2 RNA Sequence