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GSPT2 G1 to S phase transition 2 [ Homo sapiens (human) ]

Gene ID: 23708, updated on 1-Jun-2020

Summary

Official Symbol
GSPT2provided by HGNC
Official Full Name
G1 to S phase transition 2provided by HGNC
Primary source
HGNC:HGNC:4622
See related
Ensembl:ENSG00000189369 MIM:300418
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GST2; ERF3B
Summary
This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.[provided by RefSeq, Mar 2010]
Orthologs

Genomic context

See GSPT2 in Genome Data Viewer
Location:
Xp11.22
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (51743442..51746232)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (51486481..51489328)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene centromere protein V like 2 Neighboring gene centromere protein V like 1 Neighboring gene MAGE family member D1 Neighboring gene zinc finger protein 852 pseudogene Neighboring gene RNA, U6 small nuclear 504, pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10441

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation release factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic translational termination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
translation release factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
eukaryotic peptide chain release factor GTP-binding subunit ERF3B
Names
eukaryotic peptide chain release factor subunit 3b

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016857.1 RefSeqGene

    Range
    5058..7848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018094.5NP_060564.2  eukaryotic peptide chain release factor GTP-binding subunit ERF3B

    See identical proteins and their annotated locations for NP_060564.2

    Status: REVIEWED

    Source sequence(s)
    AJ251548, AK001303, BF514488, DB173006
    Consensus CDS
    CCDS14336.1
    UniProtKB/Swiss-Prot
    Q8IYD1
    Related
    ENSP00000341247.4, ENST00000340438.6
    Conserved Domains (5) summary
    cd01883
    Location:205421
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    COG5256
    Location:201625
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    pfam07145
    Location:4764
    PAM2; Ataxin-2 C-terminal region
    cd04089
    Location:430511
    eRF3_II; Domain II of the eukaryotic class II release factor
    cd03704
    Location:517623
    eRF3_C_III; C-terminal domain of eRF3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    51743442..51746232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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