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RAB38 RAB38, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 23682, updated on 23-Nov-2021

Summary

Official Symbol
RAB38provided by HGNC
Official Full Name
RAB38, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9776
See related
Ensembl:ENSG00000123892 MIM:606281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
rrGTPbp; NY-MEL-1
Expression
Biased expression in skin (RPKM 6.0), esophagus (RPKM 5.8) and 13 other tissues See more
Orthologs
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Genomic context

See RAB38 in Genome Data Viewer
Location:
11q14.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (87809490..88175504, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (87846419..87908611, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984361 Neighboring gene RNA, U6 small nuclear 1135, pseudogene Neighboring gene long intergenic non-protein coding RNA 2711 Neighboring gene MT-CYB pseudogene 41 Neighboring gene microRNA 3166 Neighboring gene cathepsin C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Frontotemporal dementia and its subtypes: a genome-wide association study.
GeneReviews: Not available
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables AP-1 adaptor complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables AP-2 adaptor complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables AP-3 adaptor complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables BLOC-2 complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GTP binding NAS
Non-traceable Author Statement
more info
PubMed 
enables GTP-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in endosome to melanosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in melanosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in melanosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in melanosome organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagosome acidification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in platelet dense granule organization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phosphatidylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in small GTPase mediated signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in early endosome lumen IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in melanosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in melanosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in melanosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in melanosome membrane TAS
Traceable Author Statement
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondria-associated endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-related protein Rab-38
Names
Rab-related GTP-binding protein
melanoma antigen NY-MEL-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022337.3NP_071732.1  ras-related protein Rab-38

    See identical proteins and their annotated locations for NP_071732.1

    Status: VALIDATED

    Source sequence(s)
    AL546159, AP001642, AP005436, BC015808
    Consensus CDS
    CCDS8281.1
    UniProtKB/Swiss-Prot
    P57729
    UniProtKB/TrEMBL
    A0A024R191
    Related
    ENSP00000243662.5, ENST00000243662.11
    Conserved Domains (1) summary
    cd04107
    Location:10208
    Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    87809490..88175504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017456.2XP_016872945.1  ras-related protein Rab-38 isoform X1

  2. XM_017017455.2XP_016872944.1  ras-related protein Rab-38 isoform X1

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160003.1 Reference GRCh38.p13 PATCHES

    Range
    160898..161792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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