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PLA2G15 phospholipase A2 group XV [ Homo sapiens (human) ]

Gene ID: 23659, updated on 25-Nov-2021

Summary

Official Symbol
PLA2G15provided by HGNC
Official Full Name
phospholipase A2 group XVprovided by HGNC
Primary source
HGNC:HGNC:17163
See related
Ensembl:ENSG00000103066 MIM:609362
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACS; LLPL; LPLA2; LYPLA3; GXVPLA2
Summary
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 17.1), heart (RPKM 11.8) and 25 other tissues See more
Orthologs
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Genomic context

See PLA2G15 in Genome Data Viewer
Location:
16q22.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (68245371..68261062)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68279276..68294961)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T cells 3 Neighboring gene ribosomal protein S12 pseudogene 27 Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene microRNA 6773 Neighboring gene Sharpr-MPRA regulatory region 10574 Neighboring gene solute carrier family 7 member 6 Neighboring gene RNA, U6 small nuclear 1262, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564A0122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables acylglycerol O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium-independent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-independent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-independent phospholipase A2 activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium-independent phospholipase A2 activity TAS
Traceable Author Statement
more info
 
enables lysophospholipase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidyl phospholipase B activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylserine 1-acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A1 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase A1 activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in ceramide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ceramide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ceramide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in diacylglycerol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fatty acid catabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in glycerophospholipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylcholine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphatidylcholine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylcholine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylethanolamine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphatidylglycerol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylserine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipid metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lysosome NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
phospholipase A2 group XV
Names
1-O-acylceramide synthase
LCAT-like lysophospholipase
group XV phospholipase A2
lysophospholipase 3 (lysosomal phospholipase A2)
lysosomal phospholipase A and acyltransferase
lysosomal phospholipase A2
NP_001350480.1
NP_036452.1
XP_011521281.1
XP_011521282.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363551.2NP_001350480.1  phospholipase A2 group XV isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC020978, AK296263
    Related
    ENSP00000457034.1, ENST00000566188.5
    Conserved Domains (1) summary
    cl21494
    Location:74167
    Abhydrolase; alpha/beta hydrolases
  2. NM_012320.4NP_036452.1  phospholipase A2 group XV isoform 1 precursor

    See identical proteins and their annotated locations for NP_036452.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK074828, BC062605
    Consensus CDS
    CCDS10864.1
    UniProtKB/Swiss-Prot
    Q8NCC3
    Related
    ENSP00000219345.5, ENST00000219345.10
    Conserved Domains (1) summary
    cl21494
    Location:74396
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    68245371..68261062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522979.2XP_011521281.1  phospholipase A2 group XV isoform X1

    See identical proteins and their annotated locations for XP_011521281.1

    Conserved Domains (1) summary
    cl21494
    Location:74428
    Abhydrolase; alpha/beta hydrolases
  2. XM_011522980.3XP_011521282.2  phospholipase A2 group XV isoform X2

    Related
    ENSP00000394197.2, ENST00000413021.2
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