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PLA2G15 phospholipase A2 group XV [ Homo sapiens (human) ]

Gene ID: 23659, updated on 5-Aug-2018

Summary

Official Symbol
PLA2G15provided by HGNC
Official Full Name
phospholipase A2 group XVprovided by HGNC
Primary source
HGNC:HGNC:17163
See related
Ensembl:ENSG00000103066 MIM:609362; Vega:OTTHUMG00000137554
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACS; LLPL; LPLA2; LYPLA3; GXVPLA2
Summary
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 17.1), heart (RPKM 11.8) and 25 other tissues See more
Orthologs

Genomic context

See PLA2G15 in Genome Data Viewer
Location:
16q22.1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (68245344..68261062)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68279240..68294965)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T cells 3 Neighboring gene ribosomal protein S12 pseudogene 27 Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene microRNA 6773 Neighboring gene solute carrier family 7 member 6 Neighboring gene RNA, U6 small nuclear 1262, pseudogene Neighboring gene solute carrier family 7 member 6 opposite strand Neighboring gene protein arginine methyltransferase 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564A0122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium-independent phospholipase A2 activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium-independent phospholipase A2 activity TAS
Traceable Author Statement
more info
 
lysophospholipase activity TAS
Traceable Author Statement
more info
PubMed 
phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ceramide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
ceramide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid catabolic process TAS
Traceable Author Statement
more info
PubMed 
glycerophospholipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylethanolamine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
phospholipid metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
lysosome NAS
Non-traceable Author Statement
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
group XV phospholipase A2
Names
1-O-acylceramide synthase
LCAT-like lysophospholipase
lysophospholipase 3 (lysosomal phospholipase A2)
lysosomal phospholipase A2
NP_036452.1
XP_005255943.1
XP_011521281.1
XP_011521282.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363551.1NP_001350480.1  group XV phospholipase A2 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC020978, AK296263
    Conserved Domains (1) summary
    cl21494
    Location:74167
    Abhydrolase; alpha/beta hydrolases
  2. NM_012320.3NP_036452.1  group XV phospholipase A2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_036452.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK074828, BC062605
    Consensus CDS
    CCDS10864.1
    UniProtKB/Swiss-Prot
    Q8NCC3
    Related
    ENSP00000219345.5, OTTHUMP00000174859, ENST00000219345.9, OTTHUMT00000268888
    Conserved Domains (1) summary
    cl21494
    Location:74396
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    68245344..68261062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522979.2XP_011521281.1  group XV phospholipase A2 isoform X1

    See identical proteins and their annotated locations for XP_011521281.1

    Conserved Domains (1) summary
    cl21494
    Location:74428
    Abhydrolase; alpha/beta hydrolases
  2. XM_005255886.4XP_005255943.1  group XV phospholipase A2 isoform X3

    See identical proteins and their annotated locations for XP_005255943.1

    UniProtKB/TrEMBL
    B4DJW4
    Related
    ENSP00000457034.1, OTTHUMP00000254758, ENST00000566188.5
    Conserved Domains (1) summary
    cl21494
    Location:74167
    Abhydrolase; alpha/beta hydrolases
  3. XM_011522980.3XP_011521282.2  group XV phospholipase A2 isoform X2

    Related
    ENSP00000394197.2, OTTHUMP00000254754, ENST00000413021.2
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