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PLA2G15 phospholipase A2 group XV [ Homo sapiens (human) ]

Gene ID: 23659, updated on 3-May-2025
Official Symbol
PLA2G15provided by HGNC
Official Full Name
phospholipase A2 group XVprovided by HGNC
Primary source
HGNC:HGNC:17163
See related
Ensembl:ENSG00000103066 MIM:609362; AllianceGenome:HGNC:17163
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACS; LLPL; LPLA2; LYPLA3; GXVPLA2
Summary
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 17.1), heart (RPKM 11.8) and 25 other tissues See more
Orthologs
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See PLA2G15 in Genome Data Viewer
Location:
16q22.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (68245373..68261058)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (74041120..74056809)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68279276..68294961)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T cells 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11007 Neighboring gene ribosomal protein S12 pseudogene 27 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7641 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68270229-68270817 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68270818-68271405 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68271406-68271994 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68271995-68272581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68278082-68278620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7644 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68279742-68280242 Neighboring gene microRNA 6773 Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene uncharacterized LOC124903704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7645 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:68298967-68300166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11009 Neighboring gene Sharpr-MPRA regulatory region 10574 Neighboring gene solute carrier family 7 member 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11010 Neighboring gene RNA, U6 small nuclear 1262, pseudogene

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • DKFZp564A0122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables acylglycerol O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acylglycerol O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium-independent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-independent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium-independent phospholipase A2 activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium-independent phospholipase A2 activity TAS
Traceable Author Statement
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lysophospholipase activity IEA
Inferred from Electronic Annotation
more info
 
enables lysophospholipase activity TAS
Traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A1 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase A1 activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A1 activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in ceramide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ceramide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ceramide metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ceramide metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ceramide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in diacylglycerol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fatty acid catabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycerophospholipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycerophospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylcholine catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylcholine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphatidylcholine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylcholine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylcholine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylethanolamine catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylethanolamine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphatidylglycerol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylserine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipid metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lysosome NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
lysosomal phospholipase A and acyltransferase
Names
1-O-acylceramide synthase
LCAT-like lysophospholipase
group XV phospholipase A2
lysophospholipase 3 (lysosomal phospholipase A2)
lysosomal phospholipase A2
NP_001350480.1
NP_036452.1
XP_011521281.1
XP_011521282.3
XP_047289843.1
XP_054235960.1
XP_054235961.1
XP_054235962.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363551.2NP_001350480.1  lysosomal phospholipase A and acyltransferase isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC020978, AK296263
    Consensus CDS
    CCDS92182.1
    UniProtKB/TrEMBL
    B4DJW4, H3BPT3
    Related
    ENSP00000457034.1, ENST00000566188.5
    Conserved Domains (1) summary
    cl21494
    Location:74167
    Abhydrolase; alpha/beta hydrolases
  2. NM_012320.4NP_036452.1  lysosomal phospholipase A and acyltransferase isoform 1 precursor

    See identical proteins and their annotated locations for NP_036452.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK074828, BC062605
    Consensus CDS
    CCDS10864.1
    UniProtKB/Swiss-Prot
    B3KMF3, B4DUD1, Q53GZ1, Q8NCC3, Q9NPQ6, Q9UG04, Q9Y2B3
    Related
    ENSP00000219345.5, ENST00000219345.10
    Conserved Domains (1) summary
    cl21494
    Location:74396
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    68245373..68261058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522979.3XP_011521281.1  lysosomal phospholipase A and acyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011521281.1

    Conserved Domains (1) summary
    cl21494
    Location:74428
    Abhydrolase; alpha/beta hydrolases
  2. XM_011522980.4XP_011521282.3  lysosomal phospholipase A and acyltransferase isoform X2

    UniProtKB/TrEMBL
    H3BPT3
    Related
    ENSP00000455461.2, ENST00000564827.6
  3. XM_047433887.1XP_047289843.1  lysosomal phospholipase A and acyltransferase isoform X3

    Related
    ENSP00000394197.2, ENST00000413021.2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    74041120..74056809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379985.1XP_054235960.1  lysosomal phospholipase A and acyltransferase isoform X1

  2. XM_054379986.1XP_054235961.1  lysosomal phospholipase A and acyltransferase isoform X2

    UniProtKB/TrEMBL
    H3BPT3
  3. XM_054379987.1XP_054235962.1  lysosomal phospholipase A and acyltransferase isoform X3