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POLA2 DNA polymerase alpha 2, accessory subunit [ Homo sapiens (human) ]

Gene ID: 23649, updated on 17-Jun-2024

Summary

Official Symbol
POLA2provided by HGNC
Official Full Name
DNA polymerase alpha 2, accessory subunitprovided by HGNC
Primary source
HGNC:HGNC:30073
See related
Ensembl:ENSG00000014138 MIM:620063; AllianceGenome:HGNC:30073
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA binding activity. Involved in DNA replication, synthesis of RNA primer. Located in cytosol and nucleoplasm. Part of alpha DNA polymerase:primase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 4.3), appendix (RPKM 2.9) and 25 other tissues See more
Orthologs
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Genomic context

See POLA2 in Genome Data Viewer
Location:
11q13.1
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65261962..65305985)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65255287..65299590)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65029433..65066156)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene hESC enhancers GRCh37_chr11:64949086-64949875 and GRCh37_chr11:64949876-64950664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64950665-64951454 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:64952638-64953204 Neighboring gene CAPN1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64953771-64954337 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64955709-64956255 Neighboring gene calpain 1 Neighboring gene MPRA-validated peak1300 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64971432-64972419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4949 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:64976880-64978079 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:64978770-64978973 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64980323-64981239 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64981240-64982155 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64984183-64984746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64984747-64985310 Neighboring gene solute carrier family 22 member 20, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr11:64989237-64989466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4951 Neighboring gene MPRA-validated peak1301 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:65011321-65011846 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3512 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:65028571-65029458 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:65029459-65030344 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:65046741-65047940 Neighboring gene uncharacterized LOC105369344 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65068776-65069313 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65069314-65069850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65077439-65078046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65078047-65078654 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3513 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3515 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:65086579-65086802 Neighboring gene CDC42 effector protein 2 Neighboring gene uncharacterized LOC124902691

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ21662, FLJ37250

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA replication NAS
Non-traceable Author Statement
more info
PubMed 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA replication initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA replication, synthesis of primer IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of alpha DNA polymerase:primase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of alpha DNA polymerase:primase complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DNA polymerase alpha subunit B
Names
DNA polymerase alpha 70 kDa subunit
polymerase (DNA directed), alpha 2 (70kD subunit)
polymerase (DNA directed), alpha 2, accessory subunit
polymerase (DNA) alpha 2, accessory subunit
polymerase (DNA-directed), alpha (70kD)
NP_002680.2
XP_011543179.1
XP_011543180.1
XP_011543181.1
XP_011543183.1
XP_016872941.1
XP_054224228.1
XP_054224229.1
XP_054224230.1
XP_054224231.1
XP_054224232.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002689.4NP_002680.2  DNA polymerase alpha subunit B

    See identical proteins and their annotated locations for NP_002680.2

    Status: VALIDATED

    Source sequence(s)
    AP000944, BC001347
    Consensus CDS
    CCDS8098.1
    UniProtKB/Swiss-Prot
    B4DNB4, Q14181, Q9BPV3
    UniProtKB/TrEMBL
    A0A9L9PX14
    Related
    ENSP00000265465.3, ENST00000265465.8
    Conserved Domains (2) summary
    COG5214
    Location:206583
    POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
    pfam08418
    Location:111238
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    65261962..65305985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544877.4XP_011543179.1  DNA polymerase alpha subunit B isoform X1

    UniProtKB/TrEMBL
    A0A9L9PX14, H0YDR7
    Related
    ENSP00000434173.2, ENST00000525924.2
    Conserved Domains (2) summary
    pfam04042
    Location:343549
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    pfam08418
    Location:111238
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
  2. XM_011544878.4XP_011543180.1  DNA polymerase alpha subunit B isoform X3

    UniProtKB/TrEMBL
    A0A9L9PX14
    Conserved Domains (2) summary
    pfam04042
    Location:343549
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    pfam08418
    Location:115238
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
  3. XM_017017452.3XP_016872941.1  DNA polymerase alpha subunit B isoform X2

    UniProtKB/TrEMBL
    A0A9L9PX14
  4. XM_011544879.3XP_011543181.1  DNA polymerase alpha subunit B isoform X4

    See identical proteins and their annotated locations for XP_011543181.1

    UniProtKB/TrEMBL
    A0A9L9PX14, A0A9L9PY44
    Related
    ENSP00000516440.1, ENST00000706538.1
    Conserved Domains (2) summary
    pfam04042
    Location:343512
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    pfam08418
    Location:115238
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
  5. XM_011544881.4XP_011543183.1  DNA polymerase alpha subunit B isoform X4

    See identical proteins and their annotated locations for XP_011543183.1

    UniProtKB/TrEMBL
    A0A9L9PX14, A0A9L9PY44
    Related
    ENSP00000516439.1, ENST00000706537.1
    Conserved Domains (2) summary
    pfam04042
    Location:343512
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    pfam08418
    Location:115238
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

RNA

  1. XR_007062468.1 RNA Sequence

  2. XR_007062469.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    65255287..65299590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368253.1XP_054224228.1  DNA polymerase alpha subunit B isoform X1

    UniProtKB/TrEMBL
    A0A9L9PX14, H0YDR7
  2. XM_054368255.1XP_054224230.1  DNA polymerase alpha subunit B isoform X3

    UniProtKB/TrEMBL
    A0A9L9PX14
  3. XM_054368256.1XP_054224231.1  DNA polymerase alpha subunit B isoform X4

    UniProtKB/TrEMBL
    A0A9L9PX14, A0A9L9PY44
  4. XM_054368254.1XP_054224229.1  DNA polymerase alpha subunit B isoform X2

    UniProtKB/TrEMBL
    A0A9L9PX14
  5. XM_054368257.1XP_054224232.1  DNA polymerase alpha subunit B isoform X4

    UniProtKB/TrEMBL
    A0A9L9PX14, A0A9L9PY44