Format

Send to:

Choose Destination

ARFIP2 ADP ribosylation factor interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 23647, updated on 8-Dec-2018

Summary

Official Symbol
ARFIP2provided by HGNC
Official Full Name
ADP ribosylation factor interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:17160
See related
Ensembl:ENSG00000132254 MIM:601638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POR1
Expression
Ubiquitous expression in prostate (RPKM 12.1), thyroid (RPKM 9.1) and 25 other tissues See more
Orthologs

Genomic context

See ARFIP2 in Genome Data Viewer
Location:
11p15.4
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (6474683..6481479, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6495913..6502709, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene hemopexin Neighboring gene tripartite motif containing 3 Neighboring gene translocase of inner mitochondrial membrane 10B Neighboring gene voltage dependent anion channel 1 pseudogene Neighboring gene dynein heavy chain domain 1 Neighboring gene ribosomal RNA processing 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Arf1 pathway, organism-specific biosystem (from Pathway Interaction Database)
    Arf1 pathway, organism-specific biosystem
    Arf1 pathway
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • PDGF Pathway, organism-specific biosystem (from WikiPathways)
    PDGF Pathway, organism-specific biosystemPDGF belongs to the PDGF/VEGF (vascular endothelial growth factor) family, which is characterized by eight strictly conserved cysteine residues with similar spacing in between (Joukov et al., 1997; H...
  • Retrograde transport at the Trans-Golgi-Network, organism-specific biosystem (from REACTOME)
    Retrograde transport at the Trans-Golgi-Network, organism-specific biosystemThe trans-Golgi network is the docking site for retrograde cargo from the endolysosomal system and the plasma membrane. Typical cargo includes recycling resident TGN proteins such as TGOLN2 (also kn...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ18046, FLJ18697, FLJ99239

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding TAS
Traceable Author Statement
more info
PubMed 
GTP-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Rac GTPase binding TAS
Traceable Author Statement
more info
PubMed 
cadherin binding HDA PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lamellipodium assembly TAS
Traceable Author Statement
more info
PubMed 
ruffle organization TAS
Traceable Author Statement
more info
PubMed 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
ruffle IMP
Inferred from Mutant Phenotype
more info
PubMed 
trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arfaptin-2
Names
partner of RAC1 (arfaptin 2)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242854.1NP_001229783.1  arfaptin-2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC084337, AK300855, BU627585, DB099222
    Consensus CDS
    CCDS73250.1
    UniProtKB/TrEMBL
    A0A087X1E4, B4DUZ3
    Related
    ENSP00000484121.1, ENST00000614314.4
    Conserved Domains (1) summary
    cd07660
    Location:169356
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  2. NM_001242855.1NP_001229784.1  arfaptin-2 isoform 3

    See identical proteins and their annotated locations for NP_001229784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream in-frame start codon, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC084337, AK301856, BU627585, DB099222
    Consensus CDS
    CCDS55740.1
    UniProtKB/Swiss-Prot
    P53365
    Related
    ENSP00000398375.2, ENST00000423813.6
    Conserved Domains (1) summary
    cd07660
    Location:98285
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  3. NM_001242856.1NP_001229785.1  arfaptin-2 isoform 4

    See identical proteins and their annotated locations for NP_001229785.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, uses an alternate downstream start codon, and lacks an internal exon in the 5' coding region, compared to variant 1. The encoded isoform (4) has a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC084337, AK304512, BU627585, DB099222
    Consensus CDS
    CCDS55739.1
    UniProtKB/Swiss-Prot
    P53365
    Related
    ENSP00000391427.2, ENST00000445086.6
    Conserved Domains (1) summary
    cd07660
    Location:51238
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  4. NM_012402.3NP_036534.1  arfaptin-2 isoform 2

    See identical proteins and their annotated locations for NP_036534.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC084337, AK301972, BC000392, BU627585, DB099222
    Consensus CDS
    CCDS7765.1
    UniProtKB/Swiss-Prot
    P53365
    UniProtKB/TrEMBL
    B4DXH2
    Related
    ENSP00000254584.2, ENST00000254584.6
    Conserved Domains (1) summary
    cd07660
    Location:136323
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    6474683..6481479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252840.4XP_005252897.1  arfaptin-2 isoform X1

    See identical proteins and their annotated locations for XP_005252897.1

    UniProtKB/Swiss-Prot
    P53365
    Related
    ENSP00000379998.3, ENST00000396777.7
    Conserved Domains (1) summary
    cd07660
    Location:136323
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
Support Center