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ARFIP2 ADP ribosylation factor interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 23647, updated on 4-Jul-2021

Summary

Official Symbol
ARFIP2provided by HGNC
Official Full Name
ADP ribosylation factor interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:17160
See related
Ensembl:ENSG00000132254 MIM:601638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POR1
Expression
Ubiquitous expression in prostate (RPKM 12.1), thyroid (RPKM 9.1) and 25 other tissues See more
Orthologs
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Genomic context

See ARFIP2 in Genome Data Viewer
Location:
11p15.4
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (6476519..6481331, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6497749..6502561, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene hemopexin Neighboring gene tripartite motif containing 3 Neighboring gene Sharpr-MPRA regulatory region 6512 Neighboring gene translocase of inner mitochondrial membrane 10B Neighboring gene voltage dependent anion channel 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ18046, FLJ18697, FLJ99239

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding TAS
Traceable Author Statement
more info
PubMed 
enables GTP-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cadherin binding HDA PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables membrane curvature sensor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lamellipodium assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ruffle organization TAS
Traceable Author Statement
more info
PubMed 
involved_in small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in ruffle IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arfaptin-2
Names
partner of RAC1 (arfaptin 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242854.3NP_001229783.1  arfaptin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Consensus CDS
    CCDS73250.1
    UniProtKB/TrEMBL
    A0A087X1E4, B4DUZ3
    Related
    ENSP00000484121.1, ENST00000614314.4
    Conserved Domains (1) summary
    cd07660
    Location:169356
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  2. NM_001242855.3NP_001229784.1  arfaptin-2 isoform 3

    See identical proteins and their annotated locations for NP_001229784.1

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Consensus CDS
    CCDS55740.1
    UniProtKB/Swiss-Prot
    P53365
    Related
    ENSP00000398375.2, ENST00000423813.6
    Conserved Domains (1) summary
    cd07660
    Location:98285
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  3. NM_001242856.3NP_001229785.1  arfaptin-2 isoform 4

    See identical proteins and their annotated locations for NP_001229785.1

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Consensus CDS
    CCDS55739.1
    UniProtKB/Swiss-Prot
    P53365
    Related
    ENSP00000391427.2, ENST00000445086.6
    Conserved Domains (1) summary
    cd07660
    Location:51238
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  4. NM_001370406.2NP_001357335.1  arfaptin-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Conserved Domains (1) summary
    cd07660
    Location:136322
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  5. NM_001370408.2NP_001357337.1  arfaptin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Conserved Domains (1) summary
    cd07660
    Location:98285
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  6. NM_001370409.2NP_001357338.1  arfaptin-2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Conserved Domains (1) summary
    cd07660
    Location:136318
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  7. NM_001370411.2NP_001357340.1  arfaptin-2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Conserved Domains (1) summary
    cd07660
    Location:136318
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  8. NM_001370412.2NP_001357341.1  arfaptin-2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Conserved Domains (1) summary
    cd07660
    Location:120307
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  9. NM_001370413.2NP_001357342.1  arfaptin-2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Conserved Domains (1) summary
    cd07660
    Location:120307
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  10. NM_001376558.2NP_001363487.1  arfaptin-2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Related
    ENSP00000379998.3, ENST00000396777.8
    Conserved Domains (1) summary
    cd07660
    Location:136323
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  11. NM_001376559.2NP_001363488.1  arfaptin-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Conserved Domains (1) summary
    cd07660
    Location:136322
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  12. NM_001376560.2NP_001363489.1  arfaptin-2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Conserved Domains (1) summary
    cd07660
    Location:136321
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  13. NM_001376561.2NP_001363490.1  arfaptin-2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Conserved Domains (1) summary
    cd07660
    Location:136290
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  14. NM_001376562.2NP_001363491.1  arfaptin-2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Conserved Domains (1) summary
    cd07660
    Location:108295
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  15. NM_001376563.2NP_001363492.1  arfaptin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Conserved Domains (1) summary
    cd07660
    Location:98285
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  16. NM_001376564.2NP_001363493.1  arfaptin-2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Conserved Domains (1) summary
    cd07660
    Location:98284
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
  17. NM_012402.5NP_036534.1  arfaptin-2 isoform 2

    See identical proteins and their annotated locations for NP_036534.1

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Consensus CDS
    CCDS7765.1
    UniProtKB/Swiss-Prot
    P53365
    UniProtKB/TrEMBL
    B4DXH2
    Related
    ENSP00000254584.2, ENST00000254584.6
    Conserved Domains (1) summary
    cd07660
    Location:136323
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

RNA

  1. NR_163423.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Related
    ENST00000531037.5
  2. NR_163424.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC084337
  3. NR_164825.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC084337
  4. NR_164826.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC084337

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    6476519..6481331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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