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CA14 carbonic anhydrase 14 [ Homo sapiens (human) ]

Gene ID: 23632, updated on 5-Aug-2018

Summary

Official Symbol
CA14provided by HGNC
Official Full Name
carbonic anhydrase 14provided by HGNC
Primary source
HGNC:HGNC:1372
See related
Ensembl:ENSG00000118298 MIM:604832; Vega:OTTHUMG00000012549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAXiV
Summary
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 3.3), skin (RPKM 1.4) and 12 other tissues See more
Orthologs

Genomic context

See CA14 in Genome Data Viewer
Location:
1q21.2
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (150257258..150265862)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150229554..150237478)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene acidic nuclear phosphoprotein 32 family member E Neighboring gene RNA, U2 small nuclear 17, pseudogene Neighboring gene small nucleolar RNA, C/D box 13C Neighboring gene aph-1 homolog A, gamma-secretase subunit Neighboring gene chromosome 1 open reading frame 54 Neighboring gene circadian associated repressor of transcription

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Nitrogen metabolism, organism-specific biosystem (from KEGG)
    Nitrogen metabolism, organism-specific biosystemThe biological process of the nitrogen cycle is a complex interplay among many microorganisms catalyzing different reactions, where nitrogen is found in various oxidation states ranging from +5 in ni...
  • Nitrogen metabolism, conserved biosystem (from KEGG)
    Nitrogen metabolism, conserved biosystemThe biological process of the nitrogen cycle is a complex interplay among many microorganisms catalyzing different reactions, where nitrogen is found in various oxidation states ranging from +5 in ni...
  • Reversible hydration of carbon dioxide, organism-specific biosystem (from REACTOME)
    Reversible hydration of carbon dioxide, organism-specific biosystemCarbonic anhydrases reversibly catalyze the hydration of carbon dioxide and directly produce bicarbonate and protons, bypassing the formation of carbonic acid (reviewed in Lindskog 1997, Breton 2001,...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbonate dehydratase activity TAS
Traceable Author Statement
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
bicarbonate transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
carbonic anhydrase 14
Names
CA-XIV
carbonate dehydratase XIV
carbonic anhydrase XIV
carbonic dehydratase
NP_036245.1
XP_005245116.1
XP_005245117.1
XP_006711322.1
XP_006711324.1
XP_011507681.1
XP_016856382.1
XP_016856383.1
XP_016856384.1
XP_016856385.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012113.2NP_036245.1  carbonic anhydrase 14 precursor

    See identical proteins and their annotated locations for NP_036245.1

    Status: REVIEWED

    Source sequence(s)
    AB025904, AK315469, BP361793
    Consensus CDS
    CCDS947.1
    UniProtKB/Swiss-Prot
    Q9ULX7
    UniProtKB/TrEMBL
    A8K3J4
    Related
    ENSP00000358107.3, OTTHUMP00000014540, ENST00000369111.8, OTTHUMT00000035064
    Conserved Domains (1) summary
    cd03126
    Location:29278
    alpha_CA_XII_XIV; Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    150257258..150265862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509379.3XP_011507681.1  carbonic anhydrase 14 isoform X2

    Conserved Domains (2) summary
    cl00012
    Location:50264
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    cl23791
    Location:277308
    UPF0154; uncharacterized protein family (UPF0154)
  2. XM_005245060.3XP_005245117.1  carbonic anhydrase 14 isoform X3

    Conserved Domains (1) summary
    cd03126
    Location:29278
    alpha_CA_XII_XIV; Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, ...
  3. XM_005245059.3XP_005245116.1  carbonic anhydrase 14 isoform X1

    See identical proteins and their annotated locations for XP_005245116.1

    Conserved Domains (1) summary
    cd03126
    Location:29278
    alpha_CA_XII_XIV; Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, ...
  4. XM_006711259.3XP_006711322.1  carbonic anhydrase 14 isoform X4

    Conserved Domains (1) summary
    cd03126
    Location:29278
    alpha_CA_XII_XIV; Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, ...
  5. XM_017000894.2XP_016856383.1  carbonic anhydrase 14 isoform X7

  6. XM_017000895.2XP_016856384.1  carbonic anhydrase 14 isoform X8

  7. XM_006711261.3XP_006711324.1  carbonic anhydrase 14 isoform X5

    Conserved Domains (2) summary
    cl00012
    Location:8222
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    cl23791
    Location:235266
    UPF0154; uncharacterized protein family (UPF0154)
  8. XM_017000893.2XP_016856382.1  carbonic anhydrase 14 isoform X6

  9. XM_017000896.2XP_016856385.1  carbonic anhydrase 14 isoform X9

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