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ARL2BP ADP ribosylation factor like GTPase 2 binding protein [ Homo sapiens (human) ]

Gene ID: 23568, updated on 17-Nov-2018

Summary

Official Symbol
ARL2BPprovided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 2 binding proteinprovided by HGNC
Primary source
HGNC:HGNC:17146
See related
Ensembl:ENSG00000102931 MIM:615407; Vega:OTTHUMG00000133459
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BART; RP66; BART1
Summary
ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 36.7), fat (RPKM 27.6) and 25 other tissues See more
Orthologs

Genomic context

See ARL2BP in Genome Data Viewer
Location:
16q13
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (57245126..57253633)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57279037..57287547)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene copine 2 Neighboring gene uncharacterized LOC105371289 Neighboring gene family with sequence similarity 192 member A Neighboring gene ring finger and SPRY domain containing 1 Neighboring gene plasmolipin Neighboring gene transfer RNA-Leu (CAG) 2-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
    Integration of energy metabolism, organism-specific biosystemMany hormones that affect individual physiological processes including the regulation of appetite, absorption, transport, and oxidation of foodstuffs influence energy metabolism pathways. While insul...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Regulation of insulin secretion, organism-specific biosystem (from REACTOME)
    Regulation of insulin secretion, organism-specific biosystemPancreatic beta cells integrate signals from several metabolites and hormones to control the secretion of insulin. In general, glucose triggers insulin secretion while other factors can amplify or in...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase regulator activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
maintenance of protein location in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin secretion TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cilium IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 2-binding protein
Names
ADP-ribosylation factor like 2 binding protein
ARF-like 2-binding protein
ARL2-binding protein
Arf-like 2 binding protein BART1
binder of ARF2 protein 1
binder of Arl Two
binder of Arl2
retinitis pigmentosa 66 (autosomal recessive)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033905.1 RefSeqGene

    Range
    5001..13508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012106.3NP_036238.1  ADP-ribosylation factor-like protein 2-binding protein

    See identical proteins and their annotated locations for NP_036238.1

    Status: REVIEWED

    Source sequence(s)
    AK075050, BC003087, BF590083
    Consensus CDS
    CCDS10776.1
    UniProtKB/Swiss-Prot
    Q9Y2Y0
    UniProtKB/TrEMBL
    A0A024R6U9
    Related
    ENSP00000219204.3, OTTHUMP00000164663, ENST00000219204.7, OTTHUMT00000257334
    Conserved Domains (1) summary
    pfam11527
    Location:25132
    ARL2_Bind_BART; The ARF-like 2 binding protein BART

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    57245126..57253633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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