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TMEM131 transmembrane protein 131 [ Homo sapiens (human) ]

Gene ID: 23505, updated on 21-Mar-2023

Summary

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Official Symbol
TMEM131provided by HGNC
Official Full Name
transmembrane protein 131provided by HGNC
Primary source
HGNC:HGNC:30366
See related
Ensembl:ENSG00000075568 MIM:615659; AllianceGenome:HGNC:30366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RW1; CC28; YR-23; PRO1048
Summary
Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon (RPKM 14.6), lymph node (RPKM 13.4) and 25 other tissues See more
Orthologs
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Genomic context

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See TMEM131 in Genome Data Viewer
Location:
2q11.2
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (97756336..97995948, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (98214553..98454161, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (98372799..98612411, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene actin related protein 1B Neighboring gene chromosome 2 open reading frame 92 Neighboring gene RNA, U4 small nuclear 8, pseudogene Neighboring gene zeta chain of T cell receptor associated protein kinase 70 Neighboring gene uncharacterized LOC124907861 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 36 Neighboring gene RNA, U7 small nuclear 96 pseudogene Neighboring gene uncharacterized LOC124905591 Neighboring gene MIR2 retrotransposon enhancer-blocking element

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Use of mRNA differential display to study the action of lymphocyte subsets in vivo and application to a murine model of herpes simplex virus infection. Tscharke DC, et al. Immunol Lett, 2000 Oct 3. PMID 10996388
  2. Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners. Alves da Silva AF, et al. PLoS One, 2016. PMID 27100087, Free PMC Article
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. Nagase T, et al. DNA Res, 1996 Oct 31. PMID 9039502
  4. The C-terminal cytoplasmic tail of hedgehog receptor Patched1 is a platform for E3 ubiquitin ligase complexes. Yamaki Y, et al. Mol Cell Biochem, 2016 Mar. PMID 26885983
  5. TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination. Wang G, et al. Ann Rheum Dis, 2020 Aug. PMID 32409323, Free PMC Article

See all (41) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0257

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein 131
Names
2610524E03Rik

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015348.2 → NP_056163.1  transmembrane protein 131

    See identical proteins and their annotated locations for NP_056163.1

    Status: VALIDATED

    Source sequence(s)
    AC092591, AK025852, AK098792, AU132630, BE327511, D87446
    Consensus CDS
    CCDS46368.1
    UniProtKB/Swiss-Prot
    Q92545
    Related
    ENSP00000186436.5, ENST00000186436.10
    Conserved Domains (1) summary
    cl13764
    Location:109 → 191
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    97756336..97995948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443844.1 → XP_047299800.1  transmembrane protein 131 isoform X6

  2. XM_047443843.1 → XP_047299799.1  transmembrane protein 131 isoform X4

  3. XM_011510869.2 → XP_011509171.1  transmembrane protein 131 isoform X5

    Conserved Domains (1) summary
    pfam12371
    Location:126 → 208
    TMEM131_like; Transmembrane protein 131-like

  4. XM_005263910.2 → XP_005263967.1  transmembrane protein 131 isoform X3

    Conserved Domains (1) summary
    pfam12371
    Location:126 → 208
    TMEM131_like; Transmembrane protein 131-like

  5. XM_005263909.2 → XP_005263966.1  transmembrane protein 131 isoform X2

    Conserved Domains (1) summary
    pfam12371
    Location:126 → 208
    TMEM131_like; Transmembrane protein 131-like

  6. XM_047443842.1 → XP_047299798.1  transmembrane protein 131 isoform X1

  7. XM_047443845.1 → XP_047299801.1  transmembrane protein 131 isoform X7

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791765.1 Reference GRCh38.p14 PATCHES

    Range
    682367..921979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332916.1 → XP_054188891.1  transmembrane protein 131 isoform X6

  2. XM_054332914.1 → XP_054188889.1  transmembrane protein 131 isoform X4

  3. XM_054332915.1 → XP_054188890.1  transmembrane protein 131 isoform X5

  4. XM_054332913.1 → XP_054188888.1  transmembrane protein 131 isoform X3

  5. XM_054332912.1 → XP_054188887.1  transmembrane protein 131 isoform X2

  6. XM_054332911.1 → XP_054188886.1  transmembrane protein 131 isoform X1

  7. XM_054332917.1 → XP_054188892.1  transmembrane protein 131 isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    98214553..98454161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341219.1 → XP_054197194.1  transmembrane protein 131 isoform X6

  2. XM_054341217.1 → XP_054197192.1  transmembrane protein 131 isoform X4

  3. XM_054341218.1 → XP_054197193.1  transmembrane protein 131 isoform X5

  4. XM_054341216.1 → XP_054197191.1  transmembrane protein 131 isoform X3

  5. XM_054341215.1 → XP_054197190.1  transmembrane protein 131 isoform X2

  6. XM_054341214.1 → XP_054197189.1  transmembrane protein 131 isoform X1

  7. XM_054341220.1 → XP_054197195.1  transmembrane protein 131 isoform X7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018497.1: Suppressed sequence

    Description
    NM_018497.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92545.3 GenPept UniProtKB/Swiss-Prot:Q92545

Gene LinkOut

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