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Piezo1 piezo-type mechanosensitive ion channel component 1 [ Mus musculus (house mouse) ]

Gene ID: 234839, updated on 20-Mar-2023

Summary

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Official Symbol
Piezo1provided by MGI
Official Full Name
piezo-type mechanosensitive ion channel component 1provided by MGI
Primary source
MGI:MGI:3603204
See related
Ensembl:ENSMUSG00000014444 AllianceGenome:MGI:3603204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam38a; mKIAA0233; 9630020g22
Summary
Enables identical protein binding activity and mechanosensitive cation channel activity. Involved in positive regulation of myotube differentiation. Acts upstream of or within cation transport; detection of mechanical stimulus; and regulation of membrane potential. Located in plasma membrane. Is expressed in several structures, including hemolymphoid system; liver; and lung. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 1 and hereditary lymphedema. Orthologous to human PIEZO1 (piezo type mechanosensitive ion channel component 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 39.8), ovary adult (RPKM 31.9) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Piezo1 in Genome Data Viewer
Location:
8; 8 E1
Exon count:
53
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123208437..123278068, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122481698..122551329, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene snail family zinc finger 3 Neighboring gene ring finger protein 166 Neighboring gene cytosolic thiouridylase subunit 2 Neighboring gene predicted gene, 26497 Neighboring gene predicted gene, 34847 Neighboring gene chromatin licensing and DNA replication factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Piezo1 alleviates acetaminophen-induced acute liver injury by activating Nrf2 and reducing mitochondrial reactive oxygen species. Wang Q, et al. Biochem Biophys Res Commun, 2023 Apr 16. PMID 36841099
  2. Functional maturation of kidney organoid tubules: PIEZO1-mediated Ca(2+) signaling. Carrisoza-Gaytan R, et al. Am J Physiol Cell Physiol, 2023 Mar 1. PMID 36745528,
  3. FM1-43 Dye Memorizes Piezo1 Activation in the Trigeminal Nociceptive System Implicated in Migraine Pain. Della Pietra A, et al. Int J Mol Sci, 2023 Jan 14. PMID 36675204, Free PMC Article
  4. Piezo1 as a force-through-membrane sensor in red blood cells. Vaisey G, et al. Elife, 2022 Dec 14. PMID 36515266, Free PMC Article
  5. Piezo1 in endothelial cells is involved in vitamin D-induced vascular calcification. Liu Z, et al. Biochem Biophys Res Commun, 2023 Jan 1. PMID 36455360

See all (152) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional maturation of kidney organoid tubules: PIEZO1-mediated Ca[2+] signaling.
    Title: Functional maturation of kidney organoid tubules: PIEZO1-mediated Ca(2+) signaling.
  2. Piezo1 alleviates acetaminophen-induced acute liver injury by activating Nrf2 and reducing mitochondrial reactive oxygen species.
    Title: Piezo1 alleviates acetaminophen-induced acute liver injury by activating Nrf2 and reducing mitochondrial reactive oxygen species.
  3. Functional Expression of Mechanosensitive Piezo1/TRPV4 Channels in Mouse Osteoblasts.
    Title: Functional Expression of Mechanosensitive Piezo1/TRPV4 Channels in Mouse Osteoblasts.
  4. FM1-43 Dye Memorizes Piezo1 Activation in the Trigeminal Nociceptive System Implicated in Migraine Pain.
    Title: FM1-43 Dye Memorizes Piezo1 Activation in the Trigeminal Nociceptive System Implicated in Migraine Pain.
  5. Microglial Piezo1 senses Abeta fibril stiffness to restrict Alzheimer's disease.
    Title: Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer's disease.
  6. Piezo1 in endothelial cells is involved in vitamin D-induced vascular calcification.
    Title: Piezo1 in endothelial cells is involved in vitamin D-induced vascular calcification.
  7. The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration.
    Title: The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration.
  8. Reprogrammed fecal and mucosa-associated intestinal microbiota and weakened mucus layer in intestinal goblet cell- specific Piezo1-deficient mice.
    Title: Reprogrammed fecal and mucosa-associated intestinal microbiota and weakened mucus layer in intestinal goblet cell- specific Piezo1-deficient mice.
  9. Activation of Piezo1 Increases Na,K-ATPase-Mediated Ion Transport in Mouse Lens.
    Title: Activation of Piezo1 Increases Na,K-ATPase-Mediated Ion Transport in Mouse Lens.
  10. Ion channel Piezo1 activation promotes aerobic glycolysis in macrophages.
    Title: Ion channel Piezo1 activation promotes aerobic glycolysis in macrophages.
Submit: New GeneRIF Correction See all GeneRIFs (113)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (10)  1 citation
  • Endonuclease-mediated (4) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mechanosensitive monoatomic cation channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mechanosensitive monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables mechanosensitive monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic cation channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in detection of mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within detection of mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic cation transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monoatomic cation transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic cation transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell-cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of integrin activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of myotube differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of myotube differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
piezo-type mechanosensitive ion channel component 1
Names
family with sequence similarity 38, member A
protein PIEZO1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037298.1 → NP_001032375.1  piezo-type mechanosensitive ion channel component 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114917
    Consensus CDS
    CCDS52695.1
    UniProtKB/TrEMBL
    E9PUQ9
    Related
    ENSMUSP00000089777.6, ENSMUST00000067252.14
    Conserved Domains (2) summary
    pfam12166
    Location:2126 → 2544
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1229 → 1452
    PIEZO; Piezo

  2. NM_001357349.1 → NP_001344278.1  piezo-type mechanosensitive ion channel component 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC114917
    Consensus CDS
    CCDS90474.1
    UniProtKB/TrEMBL
    F7AC58
    Related
    ENSMUSP00000114584.3, ENSMUST00000156333.9
    Conserved Domains (2) summary
    pfam12166
    Location:2127 → 2545
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1230 → 1453
    PIEZO; Piezo

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    123208437..123278068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530954.2 → XP_006531017.2  piezo-type mechanosensitive ion channel component 1 isoform X2

    Conserved Domains (2) summary
    pfam12166
    Location:2121 → 2539
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1224 → 1447
    PIEZO; Piezo

  2. XM_006530956.2 → XP_006531019.2  piezo-type mechanosensitive ion channel component 1 isoform X3

    Conserved Domains (2) summary
    pfam12166
    Location:2098 → 2516
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1225 → 1424
    PIEZO; Piezo

  3. XM_006530953.2 → XP_006531016.2  piezo-type mechanosensitive ion channel component 1 isoform X1

    Conserved Domains (2) summary
    pfam12166
    Location:2122 → 2540
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1225 → 1448
    PIEZO; Piezo

  4. XM_006530959.3 → XP_006531022.1  piezo-type mechanosensitive ion channel component 1 isoform X5

    Conserved Domains (2) summary
    pfam12166
    Location:1397 → 1815
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:500 → 723
    PIEZO; Piezo

  5. XM_011248372.2 → XP_011246674.1  piezo-type mechanosensitive ion channel component 1 isoform X6

    Conserved Domains (2) summary
    pfam12166
    Location:976 → 1394
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:79 → 302
    PIEZO; Piezo

  6. XM_006530957.3 → XP_006531020.2  piezo-type mechanosensitive ion channel component 1 isoform X4

    Conserved Domains (2) summary
    pfam12166
    Location:2122 → 2173
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1225 → 1448
    PIEZO; Piezo
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E2JF22.1 GenPept UniProtKB/Swiss-Prot:E2JF22

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