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Mthfsd methenyltetrahydrofolate synthetase domain containing [ Mus musculus (house mouse) ]

Gene ID: 234814, updated on 5-Mar-2024

Summary

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Official Symbol
Mthfsdprovided by MGI
Official Full Name
methenyltetrahydrofolate synthetase domain containingprovided by MGI
Primary source
MGI:MGI:2679252
See related
Ensembl:ENSMUSG00000031816 AllianceGenome:MGI:2679252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C920004D05
Summary
Predicted to enable RNA binding activity. Predicted to be active in cytoplasm. Orthologous to human MTHFSD (methenyltetrahydrofolate synthetase domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 13.1), limb E14.5 (RPKM 12.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mthfsd in Genome Data Viewer
Location:
8 E1; 8 70.31 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (121818367..121835152, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (121091628..121108413, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene Foxf1 adjacent non-coding developmental regulatory RNA Neighboring gene forkhead box F1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:123632389-123632572 Neighboring gene STARR-positive B cell enhancer ABC_E9747 Neighboring gene forkhead box C2 Neighboring gene forkhead box L1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis. MacNair L, et al. Brain, 2016 Jan. PMID 26525917
  2. The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. Grote P, et al. Dev Cell, 2013 Jan 28. PMID 23369715, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identifies DDX58 and MTHFSD as two TDP-43 targets that are misregulated in amyotrophic lateral sclerosis. 1
    Title: MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC62465

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
methenyltetrahydrofolate synthase domain-containing protein
Names
methenyltetrahydrofolate synthetase domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166482.2 → NP_001159954.1  methenyltetrahydrofolate synthase domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001159954.1

    Status: VALIDATED

    Source sequence(s)
    AC127554
    Consensus CDS
    CCDS52691.1
    UniProtKB/Swiss-Prot
    Q3URQ7, Q80WS4, Q8BUM0
    Related
    ENSMUSP00000112116.3, ENSMUST00000116415.9
    Conserved Domains (2) summary
    cl00360
    Location:9 → 210
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    cl17169
    Location:297 → 366
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001372381.1 → NP_001359310.1  methenyltetrahydrofolate synthase domain-containing protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127554
    Conserved Domains (2) summary
    cl00360
    Location:9 → 206
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    cl17169
    Location:297 → 366
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_001372383.1 → NP_001359312.1  methenyltetrahydrofolate synthase domain-containing protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127554
    Conserved Domains (2) summary
    cl00360
    Location:9 → 206
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    cl17169
    Location:297 → 366
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. NM_001372384.1 → NP_001359313.1  methenyltetrahydrofolate synthase domain-containing protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC127554
    UniProtKB/Swiss-Prot
    Q3URQ7, Q80WS4, Q8BUM0
    Conserved Domains (2) summary
    cl00360
    Location:9 → 210
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    cl17169
    Location:297 → 366
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. NM_001372385.1 → NP_001359314.1  methenyltetrahydrofolate synthase domain-containing protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC127554
    Conserved Domains (2) summary
    cl00360
    Location:10 → 187
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    cl17169
    Location:278 → 347
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. NM_001372386.1 → NP_001359315.1  methenyltetrahydrofolate synthase domain-containing protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC127554
    Conserved Domains (1) summary
    cl00360
    Location:9 → 210
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family

  7. NM_001372387.1 → NP_001359316.1  methenyltetrahydrofolate synthase domain-containing protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC127554
    UniProtKB/TrEMBL
    D3Z4L1
    Related
    ENSMUSP00000117429.2, ENSMUST00000133037.8
    Conserved Domains (1) summary
    cl00360
    Location:9 → 206
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family

  8. NM_001372388.1 → NP_001359317.1  methenyltetrahydrofolate synthase domain-containing protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC127554
    UniProtKB/TrEMBL
    D3Z0Q4
    Conserved Domains (1) summary
    cl00360
    Location:10 → 187
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family

  9. NM_001372389.1 → NP_001359318.1  methenyltetrahydrofolate synthase domain-containing protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC124170, AC127554
    Conserved Domains (1) summary
    cl00360
    Location:9 → 206
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family

  10. NM_172761.4 → NP_766349.1  methenyltetrahydrofolate synthase domain-containing protein isoform 2

    See identical proteins and their annotated locations for NP_766349.1

    Status: VALIDATED

    Source sequence(s)
    AC127554
    Consensus CDS
    CCDS22723.1
    UniProtKB/Swiss-Prot
    Q3URQ7
    Related
    ENSMUSP00000044172.6, ENSMUST00000047282.12
    Conserved Domains (2) summary
    cl00360
    Location:10 → 187
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    cl17169
    Location:278 → 347
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    121818367..121835152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530939.4 → XP_006531002.1  methenyltetrahydrofolate synthase domain-containing protein isoform X3

    See identical proteins and their annotated locations for XP_006531002.1

    Conserved Domains (2) summary
    cl00360
    Location:10 → 187
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    cl17169
    Location:278 → 347
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_006530935.5 → XP_006530998.1  methenyltetrahydrofolate synthase domain-containing protein isoform X1

    Conserved Domains (2) summary
    cl00360
    Location:81 → 278
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    cl17169
    Location:369 → 438
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_036153974.1 → XP_036009867.1  methenyltetrahydrofolate synthase domain-containing protein isoform X3

    Conserved Domains (2) summary
    cl00360
    Location:10 → 187
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    cl17169
    Location:278 → 347
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. XM_036153975.1 → XP_036009868.1  methenyltetrahydrofolate synthase domain-containing protein isoform X4

    UniProtKB/TrEMBL
    D3Z0Q4
    Related
    ENSMUSP00000115382.2, ENSMUST00000139782.8
    Conserved Domains (1) summary
    cl00360
    Location:10 → 187
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family

  5. XM_006530937.4 → XP_006531000.1  methenyltetrahydrofolate synthase domain-containing protein isoform X2

    Conserved Domains (1) summary
    cl00360
    Location:81 → 278
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family

  6. XM_017312753.3 → XP_017168242.1  methenyltetrahydrofolate synthase domain-containing protein isoform X6

    Conserved Domains (1) summary
    cl00360
    Location:81 → 193
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family

  7. XM_036153976.1 → XP_036009869.1  methenyltetrahydrofolate synthase domain-containing protein isoform X7

  8. XM_017312752.2 → XP_017168241.1  methenyltetrahydrofolate synthase domain-containing protein isoform X5

    Conserved Domains (1) summary
    cl00360
    Location:81 → 167
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3URQ7.1 GenPept UniProtKB/Swiss-Prot:Q3URQ7

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