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SEC11A SEC11 homolog A, signal peptidase complex subunit [ Homo sapiens (human) ]

Gene ID: 23478, updated on 1-Jun-2020

Summary

Official Symbol
SEC11Aprovided by HGNC
Official Full Name
SEC11 homolog A, signal peptidase complex subunitprovided by HGNC
Primary source
HGNC:HGNC:17718
See related
Ensembl:ENSG00000140612 MIM:618258
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPC18; SPCS4A; SEC11L1; sid2895; 1810012E07Rik
Summary
This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]
Expression
Ubiquitous expression in thyroid (RPKM 67.9), fat (RPKM 55.2) and 25 other tissues See more
Orthologs

Genomic context

See SEC11A in Genome Data Viewer
Location:
15q25.2-q25.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (84669537..84716460, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (85212768..85259691, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene SCAN domain containing 2 pseudogene Neighboring gene WD repeat domain 73 Neighboring gene neuromedin B Neighboring gene zinc finger protein 592 Neighboring gene skeletal muscle cis-regulatory module overlapping ALPK3 Neighboring gene alpha kinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
signal peptidase complex catalytic subunit SEC11A
Names
SEC11-like protein 1
SPase 18 kDa subunit
endopeptidase SP18
microsomal signal peptidase 18 kDa subunit
signal peptidase complex (18kD)
signal peptidase complex 18
NP_001258847.1
NP_001258848.1
NP_001258849.1
NP_001258850.1
NP_001258851.1
NP_055115.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271918.1NP_001258847.1  signal peptidase complex catalytic subunit SEC11A isoform 5

    See identical proteins and their annotated locations for NP_001258847.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate exon in the 5' coding region which results in initiation at a downstream start site and an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (5) is longer than isoform 1.
    Source sequence(s)
    AK300693, AK314146, BM985046, BP370483
    Consensus CDS
    CCDS61742.1
    UniProtKB/Swiss-Prot
    P67812
    Related
    ENSP00000413121.3, ENST00000455959.7
    Conserved Domains (1) summary
    cl10465
    Location:12124
    Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...
  2. NM_001271919.1NP_001258848.1  signal peptidase complex catalytic subunit SEC11A isoform 6

    See identical proteins and their annotated locations for NP_001258848.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame exon and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (6) is longer than isoform 1.
    Source sequence(s)
    AI051931, AK314146, BP370483, CD356160, CF455691
    UniProtKB/Swiss-Prot
    P67812
    Related
    ENSP00000453930.1, ENST00000558217.5
    Conserved Domains (1) summary
    cl10465
    Location:38103
    Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...
  3. NM_001271920.1NP_001258849.1  signal peptidase complex catalytic subunit SEC11A isoform 4

    See identical proteins and their annotated locations for NP_001258849.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two alternate exons in the central coding region which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (4) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK314146, BF920344, BG703137, BI545042, BM985046, BP370483
    Consensus CDS
    CCDS61744.1
    UniProtKB/Swiss-Prot
    P67812
    Related
    ENSP00000452684.1, ENST00000560266.5
    Conserved Domains (1) summary
    cl10465
    Location:38122
    Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...
  4. NM_001271921.1NP_001258850.1  signal peptidase complex catalytic subunit SEC11A isoform 1

    See identical proteins and their annotated locations for NP_001258850.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest isoform (1).
    Source sequence(s)
    AA151795, AF061737, BM763471, BM985046, BU540274, DA963119, HY170714
    Consensus CDS
    CCDS73776.1
    UniProtKB/Swiss-Prot
    P67812
    UniProtKB/TrEMBL
    H0YKT4
    Related
    ENSP00000452932.1, ENST00000559729.5
  5. NM_001271922.1NP_001258851.1  signal peptidase complex catalytic subunit SEC11A isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame exon and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The encoded isoform (3) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC000359, BM763471, BM904189, BM985046, BU540274, DA963119
    Consensus CDS
    CCDS61743.1
    UniProtKB/Swiss-Prot
    P67812
    Related
    ENSP00000452697.1, ENST00000558134.5
    Conserved Domains (1) summary
    cl10465
    Location:38122
    Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...
  6. NM_014300.4NP_055115.1  signal peptidase complex catalytic subunit SEC11A isoform 2

    See identical proteins and their annotated locations for NP_055115.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame exon in the central coding region, compared to variant 1. It encodes a longer protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    BC014508, DC360846
    Consensus CDS
    CCDS45340.1
    UniProtKB/Swiss-Prot
    P67812
    UniProtKB/TrEMBL
    A0A024RC78
    Related
    ENSP00000268220.7, ENST00000268220.12
    Conserved Domains (1) summary
    cl10465
    Location:38150
    Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

RNA

  1. NR_073518.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA151795, AF061737, BM763471, BM985046, CT001736, DA963119, FN058159

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    84669537..84716460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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