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SEC11A SEC11 homolog A, signal peptidase complex subunit [ Homo sapiens (human) ]

Gene ID: 23478, updated on 3-Nov-2024

Summary

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Official Symbol
SEC11Aprovided by HGNC
Official Full Name
SEC11 homolog A, signal peptidase complex subunitprovided by HGNC
Primary source
HGNC:HGNC:17718
See related
Ensembl:ENSG00000140612 MIM:618258; AllianceGenome:HGNC:17718
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPC18; SPCS4A; SEC11L1; sid2895; 1810012E07Rik
Summary
This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]
Expression
Ubiquitous expression in thyroid (RPKM 67.9), fat (RPKM 55.2) and 25 other tissues See more
Orthologs
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Genomic context

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See SEC11A in Genome Data Viewer
Location:
15q25.2-q25.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (84669544..84716139, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (82421945..82500674, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (85212775..85259370, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene SCAN domain containing 2 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:85196867-85197834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6771 Neighboring gene WD repeat domain 73 Neighboring gene neuromedin B Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85229719-85230218 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85259023-85259588 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:85259589-85260154 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:85260155-85260718 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:85276857-85277760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9991 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85291347-85292186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9992 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_41887 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85303845-85304346 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85309319-85309820 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85309821-85310320 Neighboring gene zinc finger protein 592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9993 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85325731-85326318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:85326319-85326906 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_41909 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85346873-85347374 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85347375-85347874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:85359685-85360215 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85362343-85362874 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85362875-85363404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:85370192-85370692 Neighboring gene skeletal muscle cis-regulatory module overlapping ALPK3 Neighboring gene alpha kinase 3 Neighboring gene uncharacterized LOC124900361

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CircSEC11A knockdown alleviates oxidative stress and apoptosis and promotes cell proliferation and angiogenesis by regulating miR-29a-3p/SEMA3A axis in OGD-induced human brain microvascular endothelial cells (HBMECs). Zhou Z, et al. Clin Hemorheol Microcirc, 2023. PMID 36872771
  2. Clinical Significance of SEC11A Expression in Patients With Locally Advanced Gastric Cancer. Suematsu H, et al. Anticancer Res, 2022 Dec. PMID 36456166
  3. Clinicopathological significance of SPC18 in colorectal cancer: SPC18 participates in tumor progression. Hattori T, et al. Cancer Sci, 2017 Jan. PMID 27859949, Free PMC Article
  4. SPC18 Expression Is an Independent Prognostic Indicator of Patients with Esophageal Squamous Cell Carcinoma. Yamamoto Y, et al. Pathobiology, 2020. PMID 32564026
  5. SEC11A Expression Is Associated with Basal-Like Bladder Cancer and Predicts Patient Survival. Shigematsu Y, et al. Pathobiology, 2019. PMID 31163419

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircSEC11A knockdown alleviates oxidative stress and apoptosis and promotes cell proliferation and angiogenesis by regulating miR-29a-3p/SEMA3A axis in OGD-induced human brain microvascular endothelial cells (HBMECs).
    Title: CircSEC11A knockdown alleviates oxidative stress and apoptosis and promotes cell proliferation and angiogenesis by regulating miR-29a-3p/SEMA3A axis in OGD-induced human brain microvascular endothelial cells (HBMECs).
  2. Clinical Significance of SEC11A Expression in Patients With Locally Advanced Gastric Cancer.
    Title: Clinical Significance of SEC11A Expression in Patients With Locally Advanced Gastric Cancer.
  3. MiR-873-5p modulates progression of tongue squamous cell carcinoma via targeting SEC11A.
    Title: MiR-873-5p modulates progression of tongue squamous cell carcinoma via targeting SEC11A.
  4. Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.
    Title: Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.
  5. SPC18 Expression Is an Independent Prognostic Indicator of Patients with Esophageal Squamous Cell Carcinoma.
    Title: SPC18 Expression Is an Independent Prognostic Indicator of Patients with Esophageal Squamous Cell Carcinoma.
  6. Long non-coding RNA DDX11-AS1 facilitates gastric cancer progression by regulating miR-873-5p/SPC18 axis.
    Title: Long non-coding RNA DDX11-AS1 facilitates gastric cancer progression by regulating miR-873-5p/SPC18 axis.
  7. These results indicate that SPC18 plays an important role in the progression of bladder cancer.
    Title: SEC11A Expression Is Associated with Basal-Like Bladder Cancer and Predicts Patient Survival.
  8. results suggest that SPC18 is involved in tumor progression, and is an independent prognostic classifier in patients with colorectal cancer
    Title: Clinicopathological significance of SPC18 in colorectal cancer: SPC18 participates in tumor progression.
  9. SPC18 contributes to malignant progression through promotion of TGF-alpha secretion in gastric cancer.
    Title: Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-α secretion in gastric cancer.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in response to virus TAS
Traceable Author Statement
more info
  
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal peptidase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of signal peptidase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
signal peptidase complex catalytic subunit SEC11A
Names
SEC11-like protein 1
SPase 18 kDa subunit
endopeptidase SP18
microsomal signal peptidase 18 kDa subunit
signal peptidase complex (18kD)
signal peptidase complex 18
NP_001258847.1
NP_001258848.1
NP_001258849.1
NP_001258850.1
NP_001258851.1
NP_055115.1
XP_054233621.1
XP_054233622.1
XP_054233623.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271918.2 → NP_001258847.1  signal peptidase complex catalytic subunit SEC11A isoform 5

    See identical proteins and their annotated locations for NP_001258847.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate exon in the 5' coding region which results in initiation at a downstream start site and an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (5) is longer than isoform 1.
    Source sequence(s)
    AK300693, BM985046, BP370483
    Consensus CDS
    CCDS61742.1
    UniProtKB/Swiss-Prot
    P0C7V7
    Related
    ENSP00000413121.3, ENST00000455959.7
    Conserved Domains (1) summary
    cl10465
    Location:12 → 124
    Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

  2. NM_001271919.2 → NP_001258848.1  signal peptidase complex catalytic subunit SEC11A isoform 6

    See identical proteins and their annotated locations for NP_001258848.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame exon and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (6) is longer than isoform 1.
    Source sequence(s)
    AI051931, CD356160, CF455691
    UniProtKB/TrEMBL
    H0YNA5
    Related
    ENSP00000453930.1, ENST00000558217.5
    Conserved Domains (1) summary
    cl10465
    Location:38 → 103
    Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

  3. NM_001271920.2 → NP_001258849.1  signal peptidase complex catalytic subunit SEC11A isoform 4

    See identical proteins and their annotated locations for NP_001258849.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two alternate exons in the central coding region which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (4) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BF920344, BG703137, BI545042, BM985046, BP370483
    Consensus CDS
    CCDS61744.1
    UniProtKB/TrEMBL
    H0YNG3
    Related
    ENSP00000452684.1, ENST00000560266.5
    Conserved Domains (1) summary
    cl10465
    Location:38 → 122
    Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

  4. NM_001271921.2 → NP_001258850.1  signal peptidase complex catalytic subunit SEC11A isoform 1

    See identical proteins and their annotated locations for NP_001258850.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest isoform (1).
    Source sequence(s)
    AA151795, AF061737, BM763471, HY170714
    Consensus CDS
    CCDS73776.1
    UniProtKB/TrEMBL
    H0YKT4
    Related
    ENSP00000452932.1, ENST00000559729.5

  5. NM_001271922.2 → NP_001258851.1  signal peptidase complex catalytic subunit SEC11A isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame exon and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The encoded isoform (3) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC000359, BM763471, BM904189
    Consensus CDS
    CCDS61743.1
    UniProtKB/Swiss-Prot
    P67812
    Related
    ENSP00000452697.1, ENST00000558134.5
    Conserved Domains (1) summary
    cl10465
    Location:38 → 122
    Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

  6. NM_014300.4 → NP_055115.1  signal peptidase complex catalytic subunit SEC11A isoform 2

    See identical proteins and their annotated locations for NP_055115.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame exon in the central coding region, compared to variant 1. It encodes a longer protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    BC014508, DC360846
    Consensus CDS
    CCDS45340.1
    UniProtKB/Swiss-Prot
    B2RAD7, B4DUL4, H0YK72, H0YK83, O75957, P21378, P67812, Q53FQ8
    UniProtKB/TrEMBL
    Q6IAM7
    Related
    ENSP00000268220.7, ENST00000268220.12
    Conserved Domains (1) summary
    cl10465
    Location:38 → 150
    Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

RNA

  1. NR_073518.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA151795, AF061737, BM763471, CT001736

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    84669544..84716139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    82421945..82500674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377648.1 → XP_054233623.1  signal peptidase complex catalytic subunit SEC11A isoform X1

    UniProtKB/Swiss-Prot
    B2RAD7, B4DUL4, H0YK72, H0YK83, O75957, P21378, P67812, Q53FQ8

  2. XM_054377646.1 → XP_054233621.1  signal peptidase complex catalytic subunit SEC11A isoform X1

    UniProtKB/Swiss-Prot
    B2RAD7, B4DUL4, H0YK72, H0YK83, O75957, P21378, P67812, Q53FQ8

  3. XM_054377647.1 → XP_054233622.1  signal peptidase complex catalytic subunit SEC11A isoform X1

    UniProtKB/Swiss-Prot
    B2RAD7, B4DUL4, H0YK72, H0YK83, O75957, P21378, P67812, Q53FQ8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P67812.1 GenPept UniProtKB/Swiss-Prot:P67812

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