Format

Send to:

Choose Destination

Edc4 enhancer of mRNA decapping 4 [ Mus musculus (house mouse) ]

Gene ID: 234699, updated on 5-Aug-2018

Summary

Official Symbol
Edc4provided by MGI
Official Full Name
enhancer of mRNA decapping 4provided by MGI
Primary source
MGI:MGI:2446249
See related
Ensembl:ENSMUSG00000036270 Vega:OTTMUSG00000032525
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BC022641
Summary
The protein encoded by this gene is thought to promote mRNA decay, and is known to interact with several mRNA decapping proteins. In humans, decreased expression of this gene prevents the accumulation of mRNA decapping proteins to mRNA processing bodies (P-body). Alternative splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in thymus adult (RPKM 38.7), ovary adult (RPKM 33.6) and 28 other tissues See more
Orthologs

Genomic context

See Edc4 in Genome Data Viewer
Location:
8; 8 D3
Exon count:
29
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (105880873..105893225)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (108404851..108417108)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene THAP domain containing 11 Neighboring gene nuclear transport factor 2 Neighboring gene neuritin 1-like Neighboring gene protein serine kinase H1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
deadenylation-independent decapping of nuclear-transcribed mRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
P-body ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
enhancer of mRNA-decapping protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301100.1NP_001288029.1  enhancer of mRNA-decapping protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001288029.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK146527, BB872146, BC052514, BC053081, BU709340, CB249312, DV647826
    Consensus CDS
    CCDS80923.1
    UniProtKB/Swiss-Prot
    Q3UJB9
    UniProtKB/TrEMBL
    G5E896
    Related
    ENSMUSP00000039134.9, OTTMUSP00000043161, ENSMUST00000040254.15, OTTMUST00000080922
    Conserved Domains (3) summary
    pfam16529
    Location:114440
    Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
    sd00039
    Location:304343
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:260409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_181594.3NP_853625.1  enhancer of mRNA-decapping protein 4 isoform 2

    See identical proteins and their annotated locations for NP_853625.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK152963, BB872146, BC052514, BC053081
    Consensus CDS
    CCDS52662.1
    UniProtKB/Swiss-Prot
    Q3UJB9
    UniProtKB/TrEMBL
    A0A0R4J1Q0
    Related
    ENSMUSP00000113854.1, OTTMUSP00000043162, ENSMUST00000119261.7, OTTMUST00000080923
    Conserved Domains (3) summary
    pfam16529
    Location:114440
    Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
    sd00039
    Location:304343
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:260409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    105880873..105893225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530901.2XP_006530964.1  enhancer of mRNA-decapping protein 4 isoform X1

    Conserved Domains (3) summary
    pfam16529
    Location:114440
    Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
    sd00039
    Location:304343
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:260409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006530904.2XP_006530967.1  enhancer of mRNA-decapping protein 4 isoform X4

    Conserved Domains (3) summary
    pfam16529
    Location:114440
    Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
    sd00039
    Location:304343
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:260409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_017312743.1XP_017168232.1  enhancer of mRNA-decapping protein 4 isoform X3

  4. XM_006530902.2XP_006530965.1  enhancer of mRNA-decapping protein 4 isoform X2

    Conserved Domains (3) summary
    pfam16529
    Location:114440
    Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
    sd00039
    Location:304343
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:260409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_006530905.2XP_006530968.1  enhancer of mRNA-decapping protein 4 isoform X5

Support Center