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Gpm6a glycoprotein m6a [ Mus musculus (house mouse) ]

Gene ID: 234267, updated on 12-May-2024

Summary

Official Symbol
Gpm6aprovided by MGI
Official Full Name
glycoprotein m6aprovided by MGI
Primary source
MGI:MGI:107671
See related
Ensembl:ENSMUSG00000031517 AllianceGenome:MGI:107671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M6A; Gpm6
Summary
Predicted to enable calcium channel activity. Involved in neural retina development and neuron projection morphogenesis. Acts upstream of or within response to bacterium. Located in axonal growth cone. Is expressed in central nervous system; early nephron; intraembryonic coelom; sensory organ; and upper lip. Orthologous to human GPM6A (glycoprotein M6A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 193.1), frontal lobe adult (RPKM 175.9) and 5 other tissues See more
Orthologs
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Genomic context

See Gpm6a in Genome Data Viewer
Location:
8 B1.3; 8 29.33 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (55232469..55513913)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (54779434..55060878)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21499 Neighboring gene spermatogenesis associated 4 Neighboring gene STARR-seq mESC enhancer starr_21500 Neighboring gene WD repeat domain 17 Neighboring gene STARR-seq mESC enhancer starr_21502 Neighboring gene predicted gene, 53418 Neighboring gene STARR-seq mESC enhancer starr_21503 Neighboring gene predicted gene, 57523 Neighboring gene STARR-seq mESC enhancer starr_21505 Neighboring gene STARR-positive B cell enhancer mm9_chr8:56197740-56198041 Neighboring gene STARR-positive B cell enhancer mm9_chr8:56199056-56199356 Neighboring gene a disintegrin and metallopeptidase domain 39 pseudogene Neighboring gene predicted gene, 53425

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC38999

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neural retina development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron projection morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synapse organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in synapse assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in axonal growth cone IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axonal growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in filopodium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
neuronal membrane glycoprotein M6-a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253754.1NP_001240683.1  neuronal membrane glycoprotein M6-a isoform 2

    See identical proteins and their annotated locations for NP_001240683.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different segment for its 5' end which results in the use of an alternate start codon, compared to variant 1. The encoded protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC109200, BC033357, CK623810, CX564488
    UniProtKB/TrEMBL
    Q8R1P3
    Conserved Domains (1) summary
    pfam01275
    Location:3236
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
  2. NM_001253756.1NP_001240685.1  neuronal membrane glycoprotein M6-a isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a different segment in its 5' UTR and lacks an alternate exon in the 5' coding region, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK081877, BC033357, BY247392, CD354193
    UniProtKB/Swiss-Prot
    P35802
    UniProtKB/TrEMBL
    Q542P2
    Conserved Domains (1) summary
    cl02417
    Location:1148
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
  3. NM_153581.6NP_705809.1  neuronal membrane glycoprotein M6-a isoform 1

    See identical proteins and their annotated locations for NP_705809.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AK081877, BC033357, BY247392
    Consensus CDS
    CCDS22310.1
    UniProtKB/Swiss-Prot
    P35802
    UniProtKB/TrEMBL
    Q542P2
    Related
    ENSMUSP00000033915.8, ENSMUST00000033915.9
    Conserved Domains (1) summary
    pfam01275
    Location:14247
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    55232469..55513913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)