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TMED3 transmembrane p24 trafficking protein 3 [ Homo sapiens (human) ]

Gene ID: 23423, updated on 14-Jun-2018
Official Symbol
TMED3provided by HGNC
Official Full Name
transmembrane p24 trafficking protein 3provided by HGNC
Primary source
HGNC:HGNC:28889
See related
Ensembl:ENSG00000166557 Vega:OTTHUMG00000144170
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p26; P24B; p24g4; C15orf22; p24gamma4
Expression
Ubiquitous expression in salivary gland (RPKM 12.9), thyroid (RPKM 6.0) and 23 other tissues See more
Orthologs
See TMED3 in Genome Data Viewer
Location:
15q25.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (79311062..79413886)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (79603404..79675802)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ANKRD34C antisense RNA 1 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 3 Neighboring gene ankyrin repeat domain 34C Neighboring gene KIAA1024 Neighboring gene uncharacterized LOC105370918 Neighboring gene uncharacterized LOC105370919

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
    Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
  • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
  • COPI-mediated anterograde transport, organism-specific biosystem (from REACTOME)
    COPI-mediated anterograde transport, organism-specific biosystemThe ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2...
  • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
    ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
    Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC133022

Gene Ontology Provided by GOA

Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
COPI vesicle coat ISS
Inferred from Sequence or Structural Similarity
more info
 
COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
transport vesicle TAS
Traceable Author Statement
more info
 
Preferred Names
transmembrane emp24 domain-containing protein 3
Names
integral type I protein
membrane protein p24B
p24 family protein gamma-4
testis tissue sperm-binding protein Li 48e
transmembrane emp24 protein transport domain containing 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301203.1NP_001288132.1  transmembrane emp24 domain-containing protein 3 isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC027811, AI243096, AK304148, BP260160
    Consensus CDS
    CCDS73768.1
    UniProtKB/TrEMBL
    B4E277, F5H4M7
    Related
    ENSP00000446062.1, OTTHUMP00000247595, ENST00000536821.5, OTTHUMT00000416715
    Conserved Domains (1) summary
    pfam01105
    Location:28123
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD
  2. NM_001330376.1NP_001317305.1  transmembrane emp24 domain-containing protein 3 isoform c precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 3' terminal exon and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a
    Source sequence(s)
    AC027811, AK297710, AL109713, BP260160
    Consensus CDS
    CCDS81914.1
    UniProtKB/Swiss-Prot
    Q9Y3Q3
    Related
    ENSP00000414983.2, ENST00000424155.6
  3. NM_001363735.1NP_001350664.1  transmembrane emp24 domain-containing protein 3 isoform d precursor

    Status: VALIDATED

    Source sequence(s)
    AC011797, KF459564
    Consensus CDS
    CCDS86480.1
  4. NM_007364.3NP_031390.1  transmembrane emp24 domain-containing protein 3 isoform a precursor

    See identical proteins and their annotated locations for NP_031390.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC010853, BC022232, BM699123, BP260160
    Consensus CDS
    CCDS10310.1
    UniProtKB/Swiss-Prot
    Q9Y3Q3
    UniProtKB/TrEMBL
    A0A140VKD1
    Related
    ENSP00000299705.5, OTTHUMP00000185563, ENST00000299705.9, OTTHUMT00000291369
    Conserved Domains (1) summary
    pfam01105
    Location:28205
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD

RNA

  1. NR_125394.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK075529, BC022232, BM549126, BM699123, BP260160

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    79311062..79413886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022041.1XP_016877530.1  transmembrane emp24 domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    G3V1J9
    Related
    ENSP00000440228.1, OTTHUMP00000247596, ENST00000543455.1, OTTHUMT00000416716
    Conserved Domains (1) summary
    pfam01105
    Location:28123
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD
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