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FAM189A1 family with sequence similarity 189 member A1 [ Homo sapiens (human) ]

Gene ID: 23359, updated on 11-Jun-2021

Summary

Official Symbol
FAM189A1provided by HGNC
Official Full Name
family with sequence similarity 189 member A1provided by HGNC
Primary source
HGNC:HGNC:29075
See related
Ensembl:ENSG00000104059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM228
Expression
Biased expression in brain (RPKM 3.6), colon (RPKM 1.3) and 10 other tissues See more
Orthologs
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Genomic context

See FAM189A1 in Genome Data Viewer
Location:
15q13.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (29117712..29675409, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (29409915..29967613, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene PDCD6IP pseudogene 2 Neighboring gene golgin A6 family like 7 Neighboring gene ferritin light chain pseudogene 11 Neighboring gene amyloid beta precursor protein binding family A member 2 Neighboring gene DDB1 and CUL4 associated factor 6 pseudogene Neighboring gene NSE3 homolog, SMC5-SMC6 complex component Neighboring gene Sharpr-MPRA regulatory region 3573 Neighboring gene uncharacterized LOC100130111 Neighboring gene uncharacterized LOC105370743 Neighboring gene tubulin beta class I pseudogene 8 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 5 Neighboring gene tight junction protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association of implantable cardioverter-defibrillator activation with life-threatening arrhythmias.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ61121, KIAA0574

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein FAM189A1
Names
transmembrane protein 228

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001387214.1NP_001374143.1  protein FAM189A1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC024474, AC061965, AC102941, AC107980
    Conserved Domains (2) summary
    PHA03247
    Location:226433
    PHA03247; large tegument protein UL36; Provisional
    pfam04103
    Location:34154
    CD20; CD20-like family
  2. NM_001387215.1NP_001374144.1  protein FAM189A1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC022613, AC024474, AC061965, AC107980
    Conserved Domains (2) summary
    PHA03247
    Location:175382
    PHA03247; large tegument protein UL36; Provisional
    pfam04103
    Location:1103
    CD20; CD20-like family
  3. NM_001387216.1NP_001374145.1  protein FAM189A1 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC022613, AC024474, AC061965, AC107980
    Conserved Domains (2) summary
    PHA03247
    Location:175382
    PHA03247; large tegument protein UL36; Provisional
    pfam04103
    Location:1103
    CD20; CD20-like family
  4. NM_001387217.1NP_001374146.1  protein FAM189A1 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC022613, AC024474, AC061965, AC107980
    Conserved Domains (2) summary
    PHA03247
    Location:130337
    PHA03247; large tegument protein UL36; Provisional
    pfam04103
    Location:158
    CD20; CD20-like family
  5. NM_015307.2NP_056122.1  protein FAM189A1 isoform 1

    See identical proteins and their annotated locations for NP_056122.1

    Status: VALIDATED

    Source sequence(s)
    AC024474, AC061965, AC102941, AC107980
    Consensus CDS
    CCDS45198.1
    UniProtKB/Swiss-Prot
    O60320
    Related
    ENSP00000261275.4, ENST00000261275.5
    Conserved Domains (2) summary
    pfam04103
    Location:34199
    CD20; CD20-like family
    pfam15483
    Location:319374
    DUF4641; Domain of unknown function (DUF4641)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    29117712..29675409 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521407.2XP_011519709.1  protein FAM189A1 isoform X1

    Conserved Domains (2) summary
    pfam04103
    Location:1111
    CD20; CD20-like family
    pfam15483
    Location:356411
    DUF4641; Domain of unknown function (DUF4641)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_011332701.1 Reference GRCh38.p13 PATCHES

    Range
    1280275..1847049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_187660.1 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    1392759..1959533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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