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Mtmr10 myotubularin related protein 10 [ Mus musculus (house mouse) ]

Gene ID: 233315, updated on 2-Nov-2024

Summary

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Official Symbol
Mtmr10provided by MGI
Official Full Name
myotubularin related protein 10provided by MGI
Primary source
MGI:MGI:2142292
See related
Ensembl:ENSMUSG00000030522 AllianceGenome:MGI:2142292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be active in cytoplasm. Is expressed in nose; ventricular layer; and vibrissa. Orthologous to human MTMR10 (myotubularin related protein 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 7.3), bladder adult (RPKM 6.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mtmr10 in Genome Data Viewer
Location:
7 C; 7 34.63 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (63937443..63990556)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (64287670..64340806)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily M, member 1 Neighboring gene microRNA 211 Neighboring gene STARR-seq mESC enhancer starr_19035 Neighboring gene microRNA 6416 Neighboring gene STARR-seq mESC enhancer starr_19036 Neighboring gene STARR-seq mESC enhancer starr_19037 Neighboring gene STARR-seq mESC enhancer starr_19038 Neighboring gene STARR-seq mESC enhancer starr_19039 Neighboring gene FANCD2/FANCI-associated nuclease 1 Neighboring gene SET translocation pseudogene Neighboring gene M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:71537088-71537271

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out. Loupe JM, et al. Hum Mol Genet, 2020 Nov 4. PMID 32876667, Free PMC Article
  2. Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes. Stefan M, et al. BMC Genomics, 2005 Nov 9. PMID 16280085, Free PMC Article
  3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myotubularin-related protein 10
Names
inactive phosphatidylinositol 3-phosphatase 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420415.1 → NP_001407344.1  myotubularin-related protein 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC139849

  2. NM_172742.3 → NP_766330.2  myotubularin-related protein 10 isoform 1

    See identical proteins and their annotated locations for NP_766330.2

    Status: VALIDATED

    Source sequence(s)
    AC139849
    Consensus CDS
    CCDS39976.1
    UniProtKB/Swiss-Prot
    Q6PE99, Q7TPM9
    Related
    ENSMUSP00000032736.5, ENSMUST00000032736.11
    Conserved Domains (3) summary
    cd13346
    Location:21 → 193
    PH-GRAM_MTMR10; Myotubularian (MTM) related 10 protein (MTMR10) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam12578
    Location:574 → 701
    3-PAP; Myotubularin-associated protein
    cl21483
    Location:222 → 503
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    63937443..63990556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TPM9.2 GenPept UniProtKB/Swiss-Prot:Q7TPM9

Gene LinkOut

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