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FMO4 flavin containing dimethylaniline monoxygenase 4 [ Homo sapiens (human) ]

Gene ID: 2329, updated on 7-Jun-2020

Summary

Official Symbol
FMO4provided by HGNC
Official Full Name
flavin containing dimethylaniline monoxygenase 4provided by HGNC
Primary source
HGNC:HGNC:3772
See related
Ensembl:ENSG00000076258 MIM:136131
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FMO2
Summary
Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]
Expression
Ubiquitous expression in kidney (RPKM 11.6), liver (RPKM 9.8) and 23 other tissues See more
Orthologs

Genomic context

See FMO4 in Genome Data Viewer
Location:
1q24.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (171314131..171342084)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (171283318..171311223)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371611 Neighboring gene flavin containing dimethylaniline monoxygenase 2 Neighboring gene flavin containing dimethylaniline monoxygenase 1 Neighboring gene high mobility group box 1 pseudogene 11 Neighboring gene DNA topoisomerase I pseudogene 1 Neighboring gene signal recognition particle 14 pseudogene 4 Neighboring gene GM2 ganglioside activator pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N,N-dimethylaniline monooxygenase activity NAS
Non-traceable Author Statement
more info
PubMed 
NADP binding IEA
Inferred from Electronic Annotation
more info
 
flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
drug catabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dimethylaniline monooxygenase [N-oxide-forming] 4
Names
FMO 4
dimethylaniline oxidase 4
flavin containing monooxygenase 4
hepatic flavin-containing monooxygenase 4
NP_002013.1
XP_005245102.1
XP_005245103.1
XP_005245105.1
XP_006711306.1
XP_011507649.1
XP_011507650.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002022.3NP_002013.1  dimethylaniline monooxygenase [N-oxide-forming] 4

    See identical proteins and their annotated locations for NP_002013.1

    Status: REVIEWED

    Source sequence(s)
    BC002780, BX495448
    Consensus CDS
    CCDS1295.1
    UniProtKB/Swiss-Prot
    P31512
    Related
    ENSP00000356723.3, ENST00000367749.4
    Conserved Domains (3) summary
    pfam00743
    Location:2532
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:741
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:89220
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    171314131..171342084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711243.3XP_006711306.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X5

    Conserved Domains (2) summary
    pfam00743
    Location:2355
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:741
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  2. XM_005245048.3XP_005245105.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X6

    Conserved Domains (2) summary
    pfam00743
    Location:2300
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:741
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  3. XM_005245046.3XP_005245103.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X2

    Conserved Domains (3) summary
    pfam00743
    Location:2469
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:741
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:77157
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. XM_011509347.2XP_011507649.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X3

    Conserved Domains (3) summary
    pfam00743
    Location:2436
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:741
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:89220
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. XM_005245045.3XP_005245102.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X1

    Conserved Domains (2) summary
    pfam00743
    Location:1482
    FMO-like; Flavin-binding monooxygenase-like
    cl21454
    Location:39170
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. XM_011509348.2XP_011507650.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X4

    Conserved Domains (1) summary
    pfam00743
    Location:1389
    FMO-like; Flavin-binding monooxygenase-like

RNA

  1. XR_002959842.1 RNA Sequence

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