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Vgll4 vestigial like family member 4 [ Mus musculus (house mouse) ]

Gene ID: 232334, updated on 21-Apr-2024

Summary

Official Symbol
Vgll4provided by MGI
Official Full Name
vestigial like family member 4provided by MGI
Primary source
MGI:MGI:2652840
See related
Ensembl:ENSMUSG00000030315 AllianceGenome:MGI:2652840
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VGL-4
Summary
Predicted to enable transcription coactivator binding activity. Involved in several processes, including negative regulation of cardiac muscle cell proliferation; negative regulation of hippo signaling; and positive regulation of cellular protein catabolic process. Located in nucleus. Is expressed in lung; submandibular gland primordium; tooth; and vibrissa. Orthologous to human VGLL4 (vestigial like family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 23.7), lung adult (RPKM 17.0) and 28 other tissues See more
Orthologs
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Genomic context

Location:
6 E3; 6 53.07 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (114836850..114946932, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (114860621..114970007, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene autophagy related 7 Neighboring gene predicted gene, 52917 Neighboring gene calmodulin regulated spectrin-associated protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17064 Neighboring gene STARR-positive B cell enhancer ABC_E11331 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114824988-114825171 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114825181-114825290 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114843851-114843960 Neighboring gene STARR-seq mESC enhancer starr_17069 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114870691-114870844 Neighboring gene STARR-positive B cell enhancer ABC_E4855 Neighboring gene STARR-positive B cell enhancer mm9_chr6:114872780-114873081 Neighboring gene STARR-positive B cell enhancer ABC_E4856 Neighboring gene predicted gene, 38876 Neighboring gene STARR-seq mESC enhancer starr_17074 Neighboring gene STARR-seq mESC enhancer starr_17075 Neighboring gene STARR-positive B cell enhancer ABC_E6470 Neighboring gene predicted gene, 52944 Neighboring gene TAM41 mitochondrial translocator assembly and maintenance homolog

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
transcription cofactor vestigial-like protein 4
Names
vestigial like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356371.2NP_001343300.1  transcription cofactor vestigial-like protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC149276
    UniProtKB/TrEMBL
    D3Z130, Q3TQI9
    Related
    ENSMUSP00000123139.2, ENSMUST00000147639.8
    Conserved Domains (2) summary
    smart00711
    Location:225240
    TDU; Short repeats in human TONDU, fly vestigial and other proteins
    pfam15245
    Location:8215
    VGLL4; Transcription cofactor vestigial-like protein 4
  2. NM_001411599.1NP_001398528.1  transcription cofactor vestigial-like protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC149276
    UniProtKB/TrEMBL
    Q3TQI9
  3. NM_001411600.1NP_001398529.1  transcription cofactor vestigial-like protein 4 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC149276
  4. NM_001411601.1NP_001398530.1  transcription cofactor vestigial-like protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC149276
    UniProtKB/TrEMBL
    Q3TSJ2
  5. NM_001411602.1NP_001398531.1  transcription cofactor vestigial-like protein 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC149276
  6. NM_177683.4NP_808351.1  transcription cofactor vestigial-like protein 4 isoform 1

    See identical proteins and their annotated locations for NP_808351.1

    Status: VALIDATED

    Source sequence(s)
    AC149276
    Consensus CDS
    CCDS20436.1
    UniProtKB/Swiss-Prot
    Q80V24
    Related
    ENSMUSP00000032459.8, ENSMUST00000032459.14
    Conserved Domains (2) summary
    smart00711
    Location:231246
    TDU; Short repeats in human TONDU, fly vestigial and other proteins
    pfam15245
    Location:14220
    VGLL4; Transcription cofactor vestigial-like protein 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    114836850..114946932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166060.1XP_036021953.1  transcription cofactor vestigial-like protein 4 isoform X2

    Conserved Domains (2) summary
    smart00711
    Location:194209
    TDU; Short repeats in human TONDU, fly vestigial and other proteins
    pfam15245
    Location:8184
    VGLL4; Transcription cofactor vestigial-like protein 4
  2. XM_006506012.3XP_006506075.1  transcription cofactor vestigial-like protein 4 isoform X2

    Conserved Domains (2) summary
    smart00711
    Location:194209
    TDU; Short repeats in human TONDU, fly vestigial and other proteins
    pfam15245
    Location:8184
    VGLL4; Transcription cofactor vestigial-like protein 4