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EXOC6B exocyst complex component 6B [ Homo sapiens (human) ]

Gene ID: 23233, updated on 12-Oct-2019

Summary

Official Symbol
EXOC6Bprovided by HGNC
Official Full Name
exocyst complex component 6Bprovided by HGNC
Primary source
HGNC:HGNC:17085
See related
Ensembl:ENSG00000144036 MIM:607880
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEC15B; SEC15L2; SEMDJL3
Summary
This gene encodes a protein which is a part of the evolutionarily conserved exocyst, a multimeric protein complex necessary for exocytosis, which in turn, is crucial for cell growth, polarity and migration. Disruption of this gene may be associated with phenotypes exhibiting multiple symptoms including intellectual disability and developmental delay (DD). [provided by RefSeq, Jun 2016]
Expression
Ubiquitous expression in heart (RPKM 12.8), brain (RPKM 8.7) and 23 other tissues See more
Orthologs

Genomic context

See EXOC6B in Genome Data Viewer
Location:
2p13.2
Exon count:
28
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (72175984..72826033, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (72403113..73053177, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374798 Neighboring gene cytochrome P450 family 26 subfamily B member 1 Neighboring gene ribosomal protein S15a pseudogene 13 Neighboring gene RNA, U2 small nuclear 39, pseudogene Neighboring gene VISTA enhancer hs1025 Neighboring gene sepiapterin reductase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0919, WUGSC:H_NH0343N14.1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
vesicle docking involved in exocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
exocyst IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
exocyst complex component 6B
Names
SEC15 homolog B
SEC15-like protein 2
exocyst complex component Sec15B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050967.1 RefSeqGene

    Range
    5016..655065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321729.2NP_001308658.1  exocyst complex component 6B isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC006461, AC016770, AC092630, AC104309, AC105051, BM995822
    Consensus CDS
    CCDS82468.1
    UniProtKB/TrEMBL
    A0A0U1RRB6
    Related
    ENSP00000489442.1, ENST00000634650.1
    Conserved Domains (2) summary
    pfam04091
    Location:465771
    Sec15; Exocyst complex subunit Sec15-like
    cl25732
    Location:5269
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001321730.2NP_001308659.1  exocyst complex component 6B isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC006461, AC016770, AC092630, AC104309, AC105051, BM995822
    Conserved Domains (1) summary
    pfam04091
    Location:465726
    Sec15; Exocyst complex subunit Sec15-like
  3. NM_001321731.2NP_001308660.1  exocyst complex component 6B isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC006461, AC016770, AC092630, AC104309, AC105051, BM995822
    Conserved Domains (1) summary
    pfam04091
    Location:465771
    Sec15; Exocyst complex subunit Sec15-like
  4. NM_001321733.2NP_001308662.1  exocyst complex component 6B isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC006461, AC016770, AC092630, AC104309, AC105051, BM995822
    Conserved Domains (1) summary
    pfam04091
    Location:465726
    Sec15; Exocyst complex subunit Sec15-like
  5. NM_001321734.2NP_001308663.1  exocyst complex component 6B isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC006461, AC016770, AC092630, AC104309, AC105051, BM995822
    Conserved Domains (1) summary
    pfam04091
    Location:352658
    Sec15; Exocyst complex subunit Sec15-like
  6. NM_015189.3NP_056004.1  exocyst complex component 6B isoform 2

    See identical proteins and their annotated locations for NP_056004.1

    Status: REVIEWED

    Source sequence(s)
    AB023136, AC006461, AC092630, AK026474, BM995822
    Consensus CDS
    CCDS46333.1
    UniProtKB/Swiss-Prot
    Q9Y2D4
    Related
    ENSP00000272427.6, ENST00000272427.10
    Conserved Domains (2) summary
    pfam04091
    Location:465771
    Sec15; Exocyst complex subunit Sec15-like
    cl25732
    Location:5269
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. NR_135773.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006461, AC016770, AC092630, AC104309, AC105051, BM995822
  2. NR_135774.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006461, AC016770, AC092630, AC104309, AC105051, BM995822

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    72175984..72826033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003641.1XP_016859130.1  exocyst complex component 6B isoform X3

  2. XM_017003642.1XP_016859131.1  exocyst complex component 6B isoform X4

    Conserved Domains (1) summary
    pfam04091
    Location:133439
    Sec15; Exocyst complex subunit Sec15-like
  3. XM_005264224.1XP_005264281.1  exocyst complex component 6B isoform X4

    Conserved Domains (1) summary
    pfam04091
    Location:133439
    Sec15; Exocyst complex subunit Sec15-like
  4. XM_011532711.3XP_011531013.1  exocyst complex component 6B isoform X1

    Conserved Domains (1) summary
    pfam04091
    Location:465660
    Sec15; Exocyst complex subunit Sec15-like
  5. XM_011532712.3XP_011531014.1  exocyst complex component 6B isoform X2

    Related
    ENSP00000386698.1, ENST00000410104.1
    Conserved Domains (1) summary
    pfam04091
    Location:465662
    Sec15; Exocyst complex subunit Sec15-like
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