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ACSBG1 acyl-CoA synthetase bubblegum family member 1 [ Homo sapiens (human) ]

Gene ID: 23205, updated on 8-Jul-2021

Summary

Official Symbol
ACSBG1provided by HGNC
Official Full Name
acyl-CoA synthetase bubblegum family member 1provided by HGNC
Primary source
HGNC:HGNC:29567
See related
Ensembl:ENSG00000103740 MIM:614362
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BG; BG1; BGM; LPD; GR-LACS
Summary
The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 8.4), adrenal (RPKM 6.3) and 25 other tissues See more
Orthologs
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Genomic context

See ACSBG1 in Genome Data Viewer
Location:
15q25.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (78167468..78234625, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (78459810..78526907, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 7 Neighboring gene calcium and integrin binding family member 2 Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha Neighboring gene DNAJA4 divergent transcript Neighboring gene uncharacterized LOC105370910 Neighboring gene DnaJ heat shock protein family (Hsp40) member A4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30320, KIAA0631, MGC14352

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables CoA-ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables very long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables very long-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
long-chain-fatty-acid--CoA ligase ACSBG1
Names
bubblegum
lipidosin
very long-chain acyl-CoA synthetase
NP_001186306.1
NP_055977.3
XP_011519692.1
XP_011519693.2
XP_016877514.1
XP_016877515.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199377.2NP_001186306.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC090260, AK295269, BC009289, DC401742
    UniProtKB/Swiss-Prot
    Q96GR2
    UniProtKB/TrEMBL
    B7Z2Y6
    Conserved Domains (2) summary
    cd05933
    Location:125715
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
    COG1022
    Location:103718
    FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
  2. NM_015162.5NP_055977.3  long-chain-fatty-acid--CoA ligase ACSBG1 isoform 1

    See identical proteins and their annotated locations for NP_055977.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC090260, AK054882, BC009289, DC401742
    Consensus CDS
    CCDS10298.1
    UniProtKB/Swiss-Prot
    Q96GR2
    UniProtKB/TrEMBL
    B3KNS7
    Related
    ENSP00000258873.4, ENST00000258873.9
    Conserved Domains (2) summary
    cd05933
    Location:125719
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
    COG1022
    Location:103722
    FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    78167468..78234625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022025.2XP_016877514.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1

  2. XM_011521391.2XP_011519693.2  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X4

  3. XM_011521390.3XP_011519692.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X3

    Conserved Domains (2) summary
    cd05933
    Location:103697
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
    COG1022
    Location:81700
    FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
  4. XM_017022026.1XP_016877515.1  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X2

    Conserved Domains (2) summary
    cd05933
    Location:133727
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
    COG1022
    Location:111730
    FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
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