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FAM168A family with sequence similarity 168 member A [ Homo sapiens (human) ]

Gene ID: 23201, updated on 25-Jan-2022

Summary

Official Symbol
FAM168Aprovided by HGNC
Official Full Name
family with sequence similarity 168 member Aprovided by HGNC
Primary source
HGNC:HGNC:28999
See related
Ensembl:ENSG00000054965 MIM:616316; AllianceGenome:HGNC:28999
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCRP1; KIAA0280
Summary
Involved in positive regulation of base-excision repair. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in brain (RPKM 45.1), gall bladder (RPKM 10.1) and 24 other tissues See more
Orthologs
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Genomic context

See FAM168A in Genome Data Viewer
Location:
11q13.4
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (73400487..73598112, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (73111532..73309157, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene Sharpr-MPRA regulatory region 4120 Neighboring gene Sharpr-MPRA regulatory region 2034 Neighboring gene RELT TNF receptor Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 38 Neighboring gene MIA SH3 domain ER export factor 2 pseudogene Neighboring gene pleckstrin homology domain containing B1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0280

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of base-excision repair IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein FAM168A
Names
tongue cancer chemotherapy resistance-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286050.2NP_001272979.1  protein FAM168A isoform 1

    See identical proteins and their annotated locations for NP_001272979.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AP000763, BC052341, D87470, DB074440
    Consensus CDS
    CCDS73346.1
    UniProtKB/Swiss-Prot
    Q92567
    Related
    ENSP00000064778.4, ENST00000064778.8
    Conserved Domains (1) summary
    pfam14944
    Location:1244
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1
  2. NM_001286051.2NP_001272980.1  protein FAM168A isoform 3

    See identical proteins and their annotated locations for NP_001272980.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate in-frame exons, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AP000763, DB074440, EF197985
    Consensus CDS
    CCDS66165.1
    UniProtKB/Swiss-Prot
    Q92567
    Related
    ENSP00000390501.2, ENST00000450446.6
    Conserved Domains (1) summary
    pfam14944
    Location:1129
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1
  3. NM_015159.3NP_055974.1  protein FAM168A isoform 2

    See identical proteins and their annotated locations for NP_055974.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AP000763, BC052341
    Consensus CDS
    CCDS41689.1
    UniProtKB/Swiss-Prot
    Q92567
    Related
    ENSP00000348852.4, ENST00000356467.5
    Conserved Domains (1) summary
    pfam14944
    Location:1235
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    73400487..73598112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017415.2XP_016872904.1  protein FAM168A isoform X1

    Conserved Domains (1) summary
    pfam14944
    Location:1193
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1
  2. XM_017017416.2XP_016872905.1  protein FAM168A isoform X2

    Conserved Domains (1) summary
    pfam14944
    Location:1138
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1
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