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LARP4B La ribonucleoprotein 4B [ Homo sapiens (human) ]

Gene ID: 23185, updated on 7-Jun-2020

Summary

Official Symbol
LARP4Bprovided by HGNC
Official Full Name
La ribonucleoprotein 4Bprovided by HGNC
Primary source
HGNC:HGNC:28987
See related
Ensembl:ENSG00000107929 MIM:616513
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LARP5; KIAA0217
Summary
This gene encodes a member of an evolutionarily conserved protein family implicated in RNA metabolism and translation. Members of this family are characterized by the presence of an La motif, which is often located adjacent to one or more RNA recognition motifs (RRM). Together, the two motifs constitute the functional region of the protein and enable its interaction with the RNA substrate. This protein family is divided into five sub-families: the genuine La proteins and four La-related protein (LARP) sub-families. The protein encoded by this gene belongs to LARP sub-family 4. It is a cytoplasmic protein that may play a stimulatory role in translation. [provided by RefSeq, Oct 2012]
Expression
Ubiquitous expression in thyroid (RPKM 6.7), testis (RPKM 6.0) and 25 other tissues See more
Orthologs

Genomic context

See LARP4B in Genome Data Viewer
Location:
10p15.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (806914..931900, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (852854..977645, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene disco interacting protein 2 homolog C Neighboring gene DIP2C antisense RNA 1 Neighboring gene HNF4 motif-containing MPRA enhancer 225 Neighboring gene uncharacterized LOC101927762 Neighboring gene uncharacterized LOC107984285 Neighboring gene uncharacterized LOC105376341

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686M23113

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
polysomal ribosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
la-related protein 4B
Names
La ribonucleoprotein domain family member 4B
La ribonucleoprotein domain family, member 5
la-related protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351277.2NP_001338206.1  la-related protein 4B isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
    Source sequence(s)
    AL157709, AU132926, BC152443, BM684990, HY013410
    Conserved Domains (2) summary
    cd08036
    Location:157231
    LARP_5; La RNA-binding domain of La-related protein 5
    cd12706
    Location:236312
    RRM_LARP5; RNA recognition motif in vertebrate La-related protein 5 (LARP5 or LARP4B)
  2. NM_015155.3NP_055970.1  la-related protein 4B isoform 1

    See identical proteins and their annotated locations for NP_055970.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1).
    Source sequence(s)
    AL157709, AL359878
    Consensus CDS
    CCDS31131.1
    UniProtKB/Swiss-Prot
    Q92615
    Related
    ENSP00000326128.3, ENST00000316157.8
    Conserved Domains (2) summary
    cd08036
    Location:157231
    LARP_5; La RNA-binding domain of La-related protein 5
    cd12706
    Location:236312
    RRM_LARP5; RNA recognition motif in vertebrate La-related protein 5 (LARP5 or LARP4B)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    806914..931900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015994.1XP_016871483.1  la-related protein 4B isoform X9

  2. XM_017015993.1XP_016871482.1  la-related protein 4B isoform X8

  3. XM_017015989.1XP_016871478.1  la-related protein 4B isoform X3

  4. XM_017015987.1XP_016871476.1  la-related protein 4B isoform X1

  5. XM_017015988.1XP_016871477.1  la-related protein 4B isoform X2

  6. XM_017015992.1XP_016871481.1  la-related protein 4B isoform X7

    Conserved Domains (2) summary
    cd12706
    Location:79155
    RRM_LARP5; RNA recognition motif in vertebrate La-related protein 5 (LARP5 or LARP4B)
    cl02755
    Location:2674
    LAM; LA motif RNA-binding domain
  7. XM_011519435.2XP_011517737.1  la-related protein 4B isoform X4

    See identical proteins and their annotated locations for XP_011517737.1

    Conserved Domains (2) summary
    cd08036
    Location:157231
    LARP_5; La RNA-binding domain of La-related protein 5
    cd12706
    Location:236312
    RRM_LARP5; RNA recognition motif in vertebrate La-related protein 5 (LARP5 or LARP4B)
  8. XM_017015990.1XP_016871479.1  la-related protein 4B isoform X4

    Conserved Domains (2) summary
    cd08036
    Location:157231
    LARP_5; La RNA-binding domain of La-related protein 5
    cd12706
    Location:236312
    RRM_LARP5; RNA recognition motif in vertebrate La-related protein 5 (LARP5 or LARP4B)
  9. XM_005252435.3XP_005252492.1  la-related protein 4B isoform X6

    Conserved Domains (2) summary
    cd08036
    Location:34108
    LARP_5; La RNA-binding domain of La-related protein 5
    cd12706
    Location:113189
    RRM_LARP5; RNA recognition motif in vertebrate La-related protein 5 (LARP5 or LARP4B)
  10. XM_017015991.1XP_016871480.1  la-related protein 4B isoform X5

  11. XM_017015995.1XP_016871484.1  la-related protein 4B isoform X10

RNA

  1. XR_001747070.1 RNA Sequence

  2. XR_001747069.1 RNA Sequence

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