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Sfswap splicing factor SWAP [ Mus musculus (house mouse) ]

Gene ID: 231769, updated on 8-Feb-2024

Summary

Official Symbol
Sfswapprovided by MGI
Official Full Name
splicing factor SWAPprovided by MGI
Primary source
MGI:MGI:101760
See related
Ensembl:ENSMUSG00000029439 AllianceGenome:MGI:101760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SWAP; Sfrs8; Srsf8; 1190005N23Rik; 6330437E22Rik
Summary
Predicted to enable RNA binding activity. Acts upstream of or within alternative mRNA splicing, via spliceosome and mRNA 5'-splice site recognition. Predicted to be located in nucleus. Is expressed in central nervous system and retina. Orthologous to human SFSWAP (splicing factor SWAP). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 33.7), CNS E14 (RPKM 31.0) and 28 other tissues See more
Orthologs
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Genomic context

See Sfswap in Genome Data Viewer
Location:
5 G1.3; 5 68.13 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129578286..129648448)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129501231..129571384)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54304 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:130006893-130007076 Neighboring gene predicted gene, 34468 Neighboring gene predicted gene, 40333 Neighboring gene predicted gene, 40332 Neighboring gene STARR-positive B cell enhancer ABC_E6385 Neighboring gene matrix metallopeptidase 17 Neighboring gene predicted gene 6139

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
splicing factor, suppressor of white-apricot homolog
Names
serine/arginine-rich splicing factor 8
splicing factor, arginine/serine-rich 8
suppressor of white apricot protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359952.1NP_001346881.1  splicing factor, suppressor of white-apricot homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114614, AC114657
    Conserved Domains (1) summary
    smart00648
    Location:83136
    SWAP; Suppressor-of-White-APricot splicing regulator
  2. NM_001378915.1NP_001365844.1  splicing factor, suppressor of white-apricot homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC114614, AC114657
    Conserved Domains (2) summary
    smart00648
    Location:209262
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam09750
    Location:35155
    DRY_EERY; Alternative splicing regulator
  3. NM_001378916.1NP_001365845.1  splicing factor, suppressor of white-apricot homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC114614, AC114657
    Conserved Domains (2) summary
    smart00648
    Location:209262
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam09750
    Location:35155
    DRY_EERY; Alternative splicing regulator
  4. NM_001378917.1NP_001365846.1  splicing factor, suppressor of white-apricot homolog isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC114614, AC114657
    Conserved Domains (2) summary
    smart00648
    Location:209262
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam09750
    Location:35155
    DRY_EERY; Alternative splicing regulator
  5. NM_172276.3NP_758480.2  splicing factor, suppressor of white-apricot homolog isoform 1

    See identical proteins and their annotated locations for NP_758480.2

    Status: VALIDATED

    Source sequence(s)
    AK140369, AW121884, BC057314, BY277733
    Consensus CDS
    CCDS19694.1
    UniProtKB/Swiss-Prot
    Q3USH5, Q8CCZ1
    Related
    ENSMUSP00000062413.8, ENSMUST00000053737.9
    Conserved Domains (3) summary
    smart00648
    Location:209262
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam01346
    Location:634674
    FKBP_N; Domain amino terminal to FKBP-type peptidyl-prolyl isomerase
    pfam09750
    Location:35155
    DRY_EERY; Alternative splicing regulator

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    129578286..129648448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240841.4XP_011239143.1  splicing factor, suppressor of white-apricot homolog isoform X1

    See identical proteins and their annotated locations for XP_011239143.1

    Conserved Domains (1) summary
    smart00648
    Location:83136
    SWAP; Suppressor-of-White-APricot splicing regulator
  2. XM_017320872.2XP_017176361.1  splicing factor, suppressor of white-apricot homolog isoform X4

    Conserved Domains (1) summary
    smart00648
    Location:83136
    SWAP; Suppressor-of-White-APricot splicing regulator
  3. XM_006504305.4XP_006504368.1  splicing factor, suppressor of white-apricot homolog isoform X5

    Conserved Domains (1) summary
    smart00648
    Location:83136
    SWAP; Suppressor-of-White-APricot splicing regulator
  4. XM_030254434.2XP_030110294.1  splicing factor, suppressor of white-apricot homolog isoform X6

    Conserved Domains (1) summary
    smart00648
    Location:255
    SWAP; Suppressor-of-White-APricot splicing regulator
  5. XM_030254435.2XP_030110295.1  splicing factor, suppressor of white-apricot homolog isoform X7

    Related
    ENSMUST00000199925.5
    Conserved Domains (1) summary
    smart00648
    Location:255
    SWAP; Suppressor-of-White-APricot splicing regulator
  6. XM_006504303.5XP_006504366.1  splicing factor, suppressor of white-apricot homolog isoform X1

    See identical proteins and their annotated locations for XP_006504366.1

    Conserved Domains (1) summary
    smart00648
    Location:83136
    SWAP; Suppressor-of-White-APricot splicing regulator
  7. XM_036165095.1XP_036020988.1  splicing factor, suppressor of white-apricot homolog isoform X3

    Conserved Domains (2) summary
    smart00648
    Location:209262
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam09750
    Location:35155
    DRY_EERY; Alternative splicing regulator
  8. XM_006504302.5XP_006504365.1  splicing factor, suppressor of white-apricot homolog isoform X1

    See identical proteins and their annotated locations for XP_006504365.1

    Conserved Domains (1) summary
    smart00648
    Location:83136
    SWAP; Suppressor-of-White-APricot splicing regulator
  9. XM_030254433.2XP_030110293.1  splicing factor, suppressor of white-apricot homolog isoform X2

    Conserved Domains (1) summary
    smart00648
    Location:83136
    SWAP; Suppressor-of-White-APricot splicing regulator

RNA

  1. XR_377056.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001035259.1: Suppressed sequence

    Description
    NM_001035259.1: This RefSeq was permanently suppressed because it was primarily intronic sequence.