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SNX13 sorting nexin 13 [ Homo sapiens (human) ]

Gene ID: 23161, updated on 17-Jun-2019

Summary

Official Symbol
SNX13provided by HGNC
Official Full Name
sorting nexin 13provided by HGNC
Primary source
HGNC:HGNC:21335
See related
Ensembl:ENSG00000071189 MIM:606589
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RGS-PX1
Summary
This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 8.8), testis (RPKM 6.4) and 25 other tissues See more
Orthologs

Genomic context

See SNX13 in Genome Data Viewer
Location:
7p21.1
Exon count:
33
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (17790761..17940508, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (17830385..17980141, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene renal clear cell carcinoma-associated transcript 333 Neighboring gene uncharacterized LOC105375172 Neighboring gene uncharacterized LOC101927630 Neighboring gene RNA methyltransferase like 1 pseudogene 2 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0713

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sorting nexin-13
Names
rgs domain- and phox domain-containing protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001350862.2NP_001337791.1  sorting nexin-13 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC073205, AC080080
    Related
    ENSP00000479044.1, ENST00000611725.4
    Conserved Domains (4) summary
    cd06873
    Location:557687
    PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
    cd08719
    Location:377511
    RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
    smart00313
    Location:97284
    PXA; Domain associated with PX domains
    pfam08628
    Location:803911
    Nexin_C; Sorting nexin C terminal
  2. NM_001350863.2NP_001337792.1  sorting nexin-13 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC073205, AC080080
    Conserved Domains (4) summary
    cd06873
    Location:477596
    PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
    cd08719
    Location:297431
    RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
    smart00313
    Location:17204
    PXA; Domain associated with PX domains
    pfam08628
    Location:712820
    Nexin_C; Sorting nexin C terminal
  3. NM_001350864.2NP_001337793.1  sorting nexin-13 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), encodes isoform d.
    Source sequence(s)
    AC073205, AC080080
    Conserved Domains (4) summary
    cd06873
    Location:455574
    PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
    cd08719
    Location:275409
    RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
    pfam08628
    Location:690798
    Nexin_C; Sorting nexin C terminal
    cl02564
    Location:45182
    PXA; PXA domain
  4. NM_001350866.2NP_001337795.1  sorting nexin-13 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform e.
    Source sequence(s)
    AC073205, AC080080
    Conserved Domains (4) summary
    cd06873
    Location:354473
    PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
    cd08719
    Location:174308
    RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
    pfam08628
    Location:589697
    Nexin_C; Sorting nexin C terminal
    cl02564
    Location:1381
    PXA; PXA domain
  5. NM_001350867.2NP_001337796.1  sorting nexin-13 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform e.
    Source sequence(s)
    AC073205, AC080080
    Conserved Domains (4) summary
    cd06873
    Location:354473
    PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
    cd08719
    Location:174308
    RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
    pfam08628
    Location:589697
    Nexin_C; Sorting nexin C terminal
    cl02564
    Location:1381
    PXA; PXA domain
  6. NM_001350868.1NP_001337797.1  sorting nexin-13 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC073205, AC080080
    Conserved Domains (2) summary
    cd08719
    Location:377511
    RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
    smart00313
    Location:97284
    PXA; Domain associated with PX domains
  7. NM_001350870.2NP_001337799.1  sorting nexin-13 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC073205, AC080080
    Consensus CDS
    CCDS87483.1
    Related
    ENSP00000386639.1, ENST00000409604.1
    Conserved Domains (1) summary
    cl02564
    Location:97149
    PXA; PXA domain
  8. NM_015132.5NP_055947.1  sorting nexin-13 isoform b

    See identical proteins and their annotated locations for NP_055947.1

    Status: REVIEWED

    Source sequence(s)
    AC073205, AF420470, BC045667, DB050735
    Consensus CDS
    CCDS47551.1
    UniProtKB/Swiss-Prot
    Q9Y5W8
    UniProtKB/TrEMBL
    A0A024R9Z9, Q86XC4
    Related
    ENSP00000398789.2, ENST00000428135.7
    Conserved Domains (4) summary
    cd06873
    Location:557676
    PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
    cd08719
    Location:377511
    RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
    smart00313
    Location:97284
    PXA; Domain associated with PX domains
    pfam08628
    Location:792900
    Nexin_C; Sorting nexin C terminal

RNA

  1. NR_146932.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073205, AC080080
  2. NR_146933.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073205, AC080080

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    17790761..17940508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011893.2XP_016867382.1  sorting nexin-13 isoform X2

  2. XM_011515229.2XP_011513531.1  sorting nexin-13 isoform X1

    Conserved Domains (4) summary
    cd06873
    Location:557687
    PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
    cd08719
    Location:377511
    RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
    smart00313
    Location:97284
    PXA; Domain associated with PX domains
    pfam08628
    Location:749857
    Nexin_C; Sorting nexin C terminal
  3. XM_011515233.3XP_011513535.1  sorting nexin-13 isoform X4

    Conserved Domains (4) summary
    cd06873
    Location:455585
    PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
    cd08719
    Location:275409
    RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
    pfam08628
    Location:701809
    Nexin_C; Sorting nexin C terminal
    cl02564
    Location:45182
    PXA; PXA domain
  4. XM_017011896.2XP_016867385.1  sorting nexin-13 isoform X5

    Conserved Domains (4) summary
    cd06873
    Location:428558
    PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
    cd08719
    Location:248382
    RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
    pfam08628
    Location:674782
    Nexin_C; Sorting nexin C terminal
    cl02564
    Location:18155
    PXA; PXA domain
  5. XM_011515231.2XP_011513533.1  sorting nexin-13 isoform X3

    See identical proteins and their annotated locations for XP_011513533.1

    Conserved Domains (4) summary
    cd06873
    Location:477607
    PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
    cd08719
    Location:297431
    RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
    smart00313
    Location:17204
    PXA; Domain associated with PX domains
    pfam08628
    Location:723831
    Nexin_C; Sorting nexin C terminal
  6. XM_011515230.2XP_011513532.1  sorting nexin-13 isoform X3

    See identical proteins and their annotated locations for XP_011513532.1

    Conserved Domains (4) summary
    cd06873
    Location:477607
    PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
    cd08719
    Location:297431
    RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
    smart00313
    Location:17204
    PXA; Domain associated with PX domains
    pfam08628
    Location:723831
    Nexin_C; Sorting nexin C terminal
  7. XM_024446696.1XP_024302464.1  sorting nexin-13 isoform X5

    Conserved Domains (4) summary
    cd06873
    Location:428558
    PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
    cd08719
    Location:248382
    RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
    pfam08628
    Location:674782
    Nexin_C; Sorting nexin C terminal
    cl02564
    Location:18155
    PXA; PXA domain
  8. XM_017011894.2XP_016867383.1  sorting nexin-13 isoform X3

    Conserved Domains (4) summary
    cd06873
    Location:477607
    PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
    cd08719
    Location:297431
    RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
    smart00313
    Location:17204
    PXA; Domain associated with PX domains
    pfam08628
    Location:723831
    Nexin_C; Sorting nexin C terminal
  9. XM_005249673.5XP_005249730.1  sorting nexin-13 isoform X6

    Conserved Domains (2) summary
    cd08719
    Location:377511
    RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
    smart00313
    Location:97284
    PXA; Domain associated with PX domains
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