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Arhgap24 Rho GTPase activating protein 24 [ Mus musculus (house mouse) ]

Gene ID: 231532, updated on 5-Mar-2024

Summary

Official Symbol
Arhgap24provided by MGI
Official Full Name
Rho GTPase activating protein 24provided by MGI
Primary source
MGI:MGI:1922647
See related
Ensembl:ENSMUSG00000057315 AllianceGenome:MGI:1922647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610025G21Rik
Summary
Enables GTPase activator activity. Acts upstream of or within several processes, including activation of GTPase activity; negative regulation of Rac protein signal transduction; and negative regulation of ruffle assembly. Located in focal adhesion. Is expressed in several structures, including axial skeleton; central nervous system; cranium; jaw; and metanephros. Orthologous to human ARHGAP24 (Rho GTPase activating protein 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 13.2), bladder adult (RPKM 1.9) and 11 other tissues See more
Orthologs
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Genomic context

See Arhgap24 in Genome Data Viewer
Location:
5 E5; 5 49.53 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (102355043..103053743)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (102207198..102905035)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13759 Neighboring gene STARR-seq mESC enhancer starr_13760 Neighboring gene centromere protein N pseudogene Neighboring gene STARR-seq mESC enhancer starr_13761 Neighboring gene predicted gene, 46947 Neighboring gene STARR-seq mESC enhancer starr_13762 Neighboring gene STARR-seq mESC enhancer starr_13763 Neighboring gene VISTA enhancer mm680 Neighboring gene STARR-positive B cell enhancer ABC_E2753 Neighboring gene STARR-positive B cell enhancer ABC_E2754 Neighboring gene STARR-positive B cell enhancer ABC_E8065 Neighboring gene ferredoxin 1-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_13764 Neighboring gene predicted gene, 30396 Neighboring gene STARR-seq mESC enhancer starr_13765 Neighboring gene STARR-seq mESC enhancer starr_13766 Neighboring gene STARR-seq mESC enhancer starr_13767 Neighboring gene STARR-seq mESC enhancer starr_13768 Neighboring gene STARR-seq mESC enhancer starr_13769 Neighboring gene mitogen-activated protein kinase 10 Neighboring gene STARR-seq mESC enhancer starr_13770 Neighboring gene STARR-seq mESC enhancer starr_13772 Neighboring gene RIKEN cDNA 4930429D17 gene Neighboring gene STARR-seq mESC enhancer starr_13773 Neighboring gene discs, large homolog 5 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC38749

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rho GTPase-activating protein 24
Names
rho-type GTPase-activating protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286468.1NP_001273397.1  rho GTPase-activating protein 24 isoform 2

    See identical proteins and their annotated locations for NP_001273397.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA221552, AK039617, AK080986, BB843608
    Consensus CDS
    CCDS19475.1
    UniProtKB/Swiss-Prot
    Q8C4V1, Q8CA50, Q8QZZ0
    Related
    ENSMUSP00000108473.2, ENSMUST00000112852.8
    Conserved Domains (3) summary
    cd04390
    Location:36234
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam12718
    Location:567630
    Tropomyosin_1; Tropomyosin like
    cl17171
    Location:136
    PH-like; Pleckstrin homology-like domain
  2. NM_001346585.1NP_001333514.1  rho GTPase-activating protein 24 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform 3, which has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA221552, AC125252
    Consensus CDS
    CCDS84922.1
    UniProtKB/Swiss-Prot
    Q8C4V1, Q8CA50, Q8QZZ0
    UniProtKB/TrEMBL
    D3Z5T4
    Related
    ENSMUSP00000070048.5, ENSMUST00000070000.6
  3. NM_029270.2NP_083546.2  rho GTPase-activating protein 24 isoform 1

    See identical proteins and their annotated locations for NP_083546.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA221552, AK031879, AK080986, BC027070
    Consensus CDS
    CCDS19474.1
    UniProtKB/Swiss-Prot
    Q8C4V1, Q8CA50, Q8QZZ0
    UniProtKB/TrEMBL
    G3X9N1
    Related
    ENSMUSP00000092138.3, ENSMUST00000094559.9
    Conserved Domains (3) summary
    cd04390
    Location:129327
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam12718
    Location:660723
    Tropomyosin_1; Tropomyosin like
    cl17171
    Location:20129
    PH-like; Pleckstrin homology-like domain
  4. NM_146161.3NP_666273.1  rho GTPase-activating protein 24 isoform 2

    See identical proteins and their annotated locations for NP_666273.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA221552, AK052395, AK080986, BC027070
    Consensus CDS
    CCDS19475.1
    UniProtKB/Swiss-Prot
    Q8C4V1, Q8CA50, Q8QZZ0
    Related
    ENSMUSP00000073028.6, ENSMUST00000073302.12
    Conserved Domains (3) summary
    cd04390
    Location:36234
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam12718
    Location:567630
    Tropomyosin_1; Tropomyosin like
    cl17171
    Location:136
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    102355043..103053743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534888.3XP_006534951.1  rho GTPase-activating protein 24 isoform X2

    See identical proteins and their annotated locations for XP_006534951.1

    UniProtKB/Swiss-Prot
    Q8C4V1, Q8CA50, Q8QZZ0
    UniProtKB/TrEMBL
    G3X9N1
    Conserved Domains (3) summary
    cd04390
    Location:129327
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam12718
    Location:660723
    Tropomyosin_1; Tropomyosin like
    cl17171
    Location:20129
    PH-like; Pleckstrin homology-like domain
  2. XM_036165071.1XP_036020964.1  rho GTPase-activating protein 24 isoform X1

    UniProtKB/Swiss-Prot
    Q8C4V1, Q8CA50, Q8QZZ0
    Conserved Domains (3) summary
    COG1196
    Location:705791
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd04390
    Location:186384
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    cl17171
    Location:20186
    PH-like; Pleckstrin homology-like domain
  3. XM_006534887.4XP_006534950.1  rho GTPase-activating protein 24 isoform X2

    See identical proteins and their annotated locations for XP_006534950.1

    UniProtKB/Swiss-Prot
    Q8C4V1, Q8CA50, Q8QZZ0
    UniProtKB/TrEMBL
    G3X9N1
    Conserved Domains (3) summary
    cd04390
    Location:129327
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam12718
    Location:660723
    Tropomyosin_1; Tropomyosin like
    cl17171
    Location:20129
    PH-like; Pleckstrin homology-like domain
  4. XM_036165070.1XP_036020963.1  rho GTPase-activating protein 24 isoform X1

    UniProtKB/Swiss-Prot
    Q8C4V1, Q8CA50, Q8QZZ0
    Conserved Domains (3) summary
    COG1196
    Location:705791
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd04390
    Location:186384
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    cl17171
    Location:20186
    PH-like; Pleckstrin homology-like domain
  5. XM_036165072.1XP_036020965.1  rho GTPase-activating protein 24 isoform X1

    UniProtKB/Swiss-Prot
    Q8C4V1, Q8CA50, Q8QZZ0
    Conserved Domains (3) summary
    COG1196
    Location:705791
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd04390
    Location:186384
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    cl17171
    Location:20186
    PH-like; Pleckstrin homology-like domain
  6. XM_006534891.5XP_006534954.1  rho GTPase-activating protein 24 isoform X3

    See identical proteins and their annotated locations for XP_006534954.1

    UniProtKB/Swiss-Prot
    Q8C4V1, Q8CA50, Q8QZZ0
    Related
    ENSMUSP00000108474.2, ENSMUST00000112853.8
    Conserved Domains (3) summary
    cd04390
    Location:36234
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam12718
    Location:567630
    Tropomyosin_1; Tropomyosin like
    cl17171
    Location:136
    PH-like; Pleckstrin homology-like domain
  7. XM_011249434.3XP_011247736.1  rho GTPase-activating protein 24 isoform X3

    See identical proteins and their annotated locations for XP_011247736.1

    UniProtKB/Swiss-Prot
    Q8C4V1, Q8CA50, Q8QZZ0
    Conserved Domains (3) summary
    cd04390
    Location:36234
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam12718
    Location:567630
    Tropomyosin_1; Tropomyosin like
    cl17171
    Location:136
    PH-like; Pleckstrin homology-like domain
  8. XM_006534892.4XP_006534955.1  rho GTPase-activating protein 24 isoform X4

    UniProtKB/Swiss-Prot
    Q8C4V1, Q8CA50, Q8QZZ0
    Conserved Domains (2) summary
    cd04390
    Location:5203
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam12718
    Location:536599
    Tropomyosin_1; Tropomyosin like