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ZC3H3 zinc finger CCCH-type containing 3 [ Homo sapiens (human) ]

Gene ID: 23144, updated on 21-Dec-2019

Summary

Official Symbol
ZC3H3provided by HGNC
Official Full Name
zinc finger CCCH-type containing 3provided by HGNC
Primary source
HGNC:HGNC:28972
See related
Ensembl:ENSG00000014164 MIM:618640
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMICL; ZC3HDC3
Expression
Ubiquitous expression in bone marrow (RPKM 6.1), testis (RPKM 5.7) and 25 other tissues See more
Orthologs

Genomic context

See ZC3H3 in Genome Data Viewer
Location:
8q24.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (143437655..143549729, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144519825..144624449, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene MAFA antisense RNA 1 Neighboring gene MAF bZIP transcription factor A Neighboring gene Sharpr-MPRA regulatory region 10662 Neighboring gene small nucleolar RNA, C/D box 149 Neighboring gene RN7SK pseudogene 175 Neighboring gene uncharacterized LOC100310756 Neighboring gene gasdermin D Neighboring gene maestro heat like repeat family member 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0150

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
R-SMAD binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of activin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of mRNA polyadenylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mRNA cleavage and polyadenylation specificity factor complex IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger CCCH domain-containing protein 3
Names
smad-interacting CPSF-like factor
zinc finger CCCH-type domain containing 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015117.3NP_055932.2  zinc finger CCCH domain-containing protein 3

    See identical proteins and their annotated locations for NP_055932.2

    Status: VALIDATED

    Source sequence(s)
    AA806585, AC067930, BM148116, D63484
    Consensus CDS
    CCDS6402.1
    UniProtKB/Swiss-Prot
    Q8IXZ2
    Related
    ENSP00000262577.5, ENST00000262577.6
    Conserved Domains (2) summary
    smart00356
    Location:750776
    ZnF_C3H1; zinc finger
    pfam00642
    Location:668694
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    143437655..143549729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013248.1XP_016868737.1  zinc finger CCCH domain-containing protein 3 isoform X1

  2. XM_006716536.3XP_006716599.2  zinc finger CCCH domain-containing protein 3 isoform X2

    Conserved Domains (2) summary
    smart00356
    Location:812838
    ZnF_C3H1; zinc finger
    pfam00642
    Location:730756
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
  3. XM_017013249.1XP_016868738.1  zinc finger CCCH domain-containing protein 3 isoform X1

  4. XM_011516943.2XP_011515245.1  zinc finger CCCH domain-containing protein 3 isoform X3

    Conserved Domains (2) summary
    smart00356
    Location:737762
    ZnF_C3H1; zinc finger
    pfam00642
    Location:682708
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
  5. XM_011516944.2XP_011515246.1  zinc finger CCCH domain-containing protein 3 isoform X4

RNA

  1. XR_928313.3 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187571.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    5375..31487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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