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Zfyve28 zinc finger, FYVE domain containing 28 [ Mus musculus (house mouse) ]

Gene ID: 231125, updated on 2-Nov-2024

Summary

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Official Symbol
Zfyve28provided by MGI
Official Full Name
zinc finger, FYVE domain containing 28provided by MGI
Primary source
MGI:MGI:2684992
See related
Ensembl:ENSMUSG00000037224 AllianceGenome:MGI:2684992
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm146; mKIAA1643; 9630058O20Rik
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity. Predicted to be located in cytosol. Predicted to be active in early endosome membrane. Orthologous to human ZFYVE28 (zinc finger FYVE-type containing 28). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 4.9), cortex adult (RPKM 3.0) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Zfyve28 in Genome Data Viewer
Location:
5 B2; 5 17.85 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (34352237..34445796, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (34194893..34288368, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene DNA polymerase N Neighboring gene STARR-positive B cell enhancer ABC_E1299 Neighboring gene STARR-seq mESC enhancer starr_12836 Neighboring gene predicted gene, 25918 Neighboring gene HAUS augmin-like complex, subunit 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34530746-34530855 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34537815-34537924 Neighboring gene Max dimerization protein 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34575558-34575759 Neighboring gene cilia and flagella associated protein 99 Neighboring gene RIKEN cDNA A830049F12 gene Neighboring gene predicted gene 5553 Neighboring gene STARR-positive B cell enhancer ABC_E668 Neighboring gene ring finger protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZFYVE28 mediates insulin resistance by promoting phosphorylated insulin receptor degradation via increasing late endosomes production. Yu L, et al. Nat Commun, 2023 Oct 26. PMID 37884540, Free PMC Article
  2. FYVE domain-containing protein ZFYVE28 regulates EGFR-signaling in podocytes but is not critical for the function of filtration barrier in mice. Zambrano S, et al. Sci Rep, 2018 Mar 16. PMID 29549365, Free PMC Article
  3. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
  4. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

General gene information

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Markers

Homology

Clone Names

  • AC104889.1

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epidermal growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of epidermal growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epidermal growth factor-activated receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
lateral signaling target protein 2 homolog
Names
zinc finger FYVE domain-containing protein 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015039.1 → NP_001015039.1  lateral signaling target protein 2 homolog

    See identical proteins and their annotated locations for NP_001015039.1

    Status: PROVISIONAL

    Source sequence(s)
    AK129414
    Consensus CDS
    CCDS39068.1
    UniProtKB/Swiss-Prot
    B2RSX8, Q6ZPK7
    Related
    ENSMUSP00000092464.4, ENSMUST00000094868.10
    Conserved Domains (1) summary
    cd15731
    Location:828 → 892
    FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    34352237..34445796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503886.2 → XP_006503949.1  lateral signaling target protein 2 homolog isoform X2

    Conserved Domains (1) summary
    cd15731
    Location:781 → 845
    FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

  2. XM_036165019.1 → XP_036020912.1  lateral signaling target protein 2 homolog isoform X1

    Conserved Domains (1) summary
    cd15731
    Location:724 → 788
    FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

  3. XM_011240724.1 → XP_011239026.1  lateral signaling target protein 2 homolog isoform X4

    Conserved Domains (1) summary
    cd15731
    Location:323 → 387
    FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

  4. XM_006503887.1 → XP_006503950.1  lateral signaling target protein 2 homolog isoform X3

    Conserved Domains (1) summary
    cd15731
    Location:614 → 678
    FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

  5. XM_017320831.3 → XP_017176320.1  lateral signaling target protein 2 homolog isoform X5

    Conserved Domains (1) summary
    cd15731
    Location:494 → 558
    FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

  6. XM_011240725.2 → XP_011239027.1  lateral signaling target protein 2 homolog isoform X6

  7. XM_011240726.4 → XP_011239028.2  lateral signaling target protein 2 homolog isoform X8

  8. XM_011240727.4 → XP_011239029.2  lateral signaling target protein 2 homolog isoform X9

  9. XM_011240728.2 → XP_011239030.1  lateral signaling target protein 2 homolog isoform X7

    See identical proteins and their annotated locations for XP_011239030.1

RNA

  1. XR_003955626.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZPK7.2 GenPept UniProtKB/Swiss-Prot:Q6ZPK7

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