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Insig1 insulin induced gene 1 [ Mus musculus (house mouse) ]

Gene ID: 231070, updated on 8-Feb-2024

Summary

Official Symbol
Insig1provided by MGI
Official Full Name
insulin induced gene 1provided by MGI
Primary source
MGI:MGI:1916289
See related
Ensembl:ENSMUSG00000045294 AllianceGenome:MGI:1916289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Insig-1; 1810013C12Rik
Summary
Predicted to enable oxysterol binding activity. Acts upstream of or within several processes, including ear morphogenesis; negative regulation of fat cell differentiation; and negative regulation of lipid biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of SREBP-SCAP-Insig complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; ganglia; neural retina; telencephalon ventricular layer; and vibrissa. Orthologous to human INSIG1 (insulin induced gene 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 186.8), adrenal adult (RPKM 174.3) and 26 other tissues See more
Orthologs
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Genomic context

See Insig1 in Genome Data Viewer
Location:
5 B1; 5 13.94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (28276410..28283660)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (28071412..28078662)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene microfibrillar-associated protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12712 Neighboring gene predicted gene, 35223 Neighboring gene predicted gene, 26608 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:28398384-28398567 Neighboring gene predicted gene, 35055 Neighboring gene STARR-seq mESC enhancer starr_12713 Neighboring gene engrailed 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables oxysterol binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein sequestering activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in SREBP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in SREBP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in SREBP-SCAP complex retention in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in SREBP-SCAP complex retention in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to sterol ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cholesterol biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cholesterol metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cranial suture morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within inner ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within middle ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cargo loading into COPII-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of fatty acid biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of protein exit from endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of steroid biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to sterol depletion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within roof of mouth development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within sterol biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within triglyceride metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of SREBP-SCAP-Insig complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SREBP-SCAP-Insig complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
insulin-induced gene 1 protein
Names
INSIG-1 membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153526.5NP_705746.1  insulin-induced gene 1 protein

    See identical proteins and their annotated locations for NP_705746.1

    Status: VALIDATED

    Source sequence(s)
    AK151186, BC079559
    Consensus CDS
    CCDS19142.1
    UniProtKB/Swiss-Prot
    A2RSM6, Q3UAX9, Q3UX30, Q8BGI3
    Related
    ENSMUSP00000061877.11, ENSMUST00000059155.11
    Conserved Domains (1) summary
    pfam07281
    Location:69249
    INSIG; Insulin-induced protein (INSIG)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    28276410..28283660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)