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Rhbdl2 rhomboid like 2 [ Mus musculus (house mouse) ]

Gene ID: 230726, updated on 7-Jan-2023

Summary

Official Symbol
Rhbdl2provided by MGI
Official Full Name
rhomboid like 2provided by MGI
Primary source
MGI:MGI:3608413
See related
Ensembl:ENSMUSG00000043333 AllianceGenome:MGI:3608413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RRP2; 9130416B15
Summary
Enables serine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in plasma membrane. Is expressed in bone; genitourinary system; and rib. Orthologous to human RHBDL2 (rhomboid like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 4.9), colon adult (RPKM 4.8) and 9 other tissues See more
Orthologs
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Genomic context

See Rhbdl2 in Genome Data Viewer
Location:
4; 4 D2.2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (123681668..123723989)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (123787875..123830196)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene akirin 1 Neighboring gene eukaryotic translation initiation factor 2C, 2 pseudogene Neighboring gene RIKEN cDNA 1700121C08 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rhomboid-related protein 2
Names
rhomboid, veinlet-like 2
NP_001343374.1
NP_898986.2
XP_006503088.1
XP_036019936.1
XP_036019937.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356445.2NP_001343374.1  rhomboid-related protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL683811
    Conserved Domains (1) summary
    pfam01694
    Location:51203
    Rhomboid; Rhomboid family
  2. NM_183163.3NP_898986.2  rhomboid-related protein 2 isoform 1

    See identical proteins and their annotated locations for NP_898986.2

    Status: VALIDATED

    Source sequence(s)
    AL683811
    Consensus CDS
    CCDS38873.1
    UniProtKB/Swiss-Prot
    A2AGA4
    Related
    ENSMUSP00000054546.6, ENSMUST00000053202.12
    Conserved Domains (1) summary
    pfam01694
    Location:115264
    Rhomboid; Rhomboid family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    123681668..123723989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164044.1XP_036019937.1  rhomboid-related protein 2 isoform X2

    Conserved Domains (1) summary
    pfam01694
    Location:51203
    Rhomboid; Rhomboid family
  2. XM_006503025.5XP_006503088.1  rhomboid-related protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006503088.1

    UniProtKB/Swiss-Prot
    A2AGA4
    Conserved Domains (1) summary
    pfam01694
    Location:115264
    Rhomboid; Rhomboid family
  3. XM_036164043.1XP_036019936.1  rhomboid-related protein 2 isoform X2

    Conserved Domains (1) summary
    pfam01694
    Location:51203
    Rhomboid; Rhomboid family