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HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

Gene ID: 23072, updated on 13-Mar-2020

Summary

Official Symbol
HECW1provided by HGNC
Official Full Name
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1provided by HGNC
Primary source
HGNC:HGNC:22195
See related
Ensembl:ENSG00000002746 MIM:610384
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEDL1
Expression
Biased expression in kidney (RPKM 3.0), brain (RPKM 2.6) and 3 other tissues See more
Orthologs

Genomic context

See HECW1 in Genome Data Viewer
Location:
7p14.1-p13
Exon count:
36
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (43112580..43566001)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (43152198..43603213)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375253 Neighboring gene uncharacterized LOC107986790 Neighboring gene HECW1 intronic transcript 1 Neighboring gene microRNA 3943 Neighboring gene RNA, U7 small nuclear 35 pseudogene Neighboring gene RNA, U6 small nuclear 575, pseudogene Neighboring gene uncharacterized LOC102724903 Neighboring gene ribosomal protein L18a pseudogene 10 Neighboring gene lncRNA upregulator of antiviral response interferon signaling Neighboring gene serine/threonine kinase 17a Neighboring gene NFE2L2 motif-containing MPRA enhancer 272 Neighboring gene cytochrome c oxidase assembly factor 1 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.
NHGRI GWA Catalog
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies in african americans provides insights into the genetic architecture of type 2 diabetes.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0322

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase HECW1
Names
HECT type E3 ubiquitin ligase
HECT-type E3 ubiquitin transferase HECW1
NEDD4-like ubiquitin-protein ligase 1
NP_001273988.1
NP_055867.3
XP_005249722.1
XP_006715733.1
XP_006715734.1
XP_006715736.1
XP_011513522.1
XP_011513524.1
XP_011513525.1
XP_011513526.1
XP_011513527.2
XP_011513528.1
XP_016867371.1
XP_016867372.1
XP_016867373.1
XP_016867374.1
XP_016867375.1
XP_016867376.1
XP_016867377.1
XP_016867378.1
XP_016867379.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287059.2NP_001273988.1  E3 ubiquitin-protein ligase HECW1 isoform b

    See identical proteins and their annotated locations for NP_001273988.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC004692, AC011738, AK294918, BC151227
    Consensus CDS
    CCDS69286.1
    UniProtKB/Swiss-Prot
    Q76N89
    Related
    ENSP00000407774.1, ENST00000453890.5
    Conserved Domains (6) summary
    cd08691
    Location:205341
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:9861017
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:12401569
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:12161570
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:799827
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam16562
    Location:65184
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
  2. NM_015052.5NP_055867.3  E3 ubiquitin-protein ligase HECW1 isoform a

    See identical proteins and their annotated locations for NP_055867.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC011738, AK294918, BC151227
    Consensus CDS
    CCDS5469.2
    UniProtKB/Swiss-Prot
    Q76N89
    Related
    ENSP00000379228.1, ENST00000395891.7
    Conserved Domains (5) summary
    cd08691
    Location:205341
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:830861
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:12741603
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:12501604
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam16562
    Location:65184
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    43112580..43566001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011886.1XP_016867375.1  E3 ubiquitin-protein ligase HECW1 isoform X6

    UniProtKB/Swiss-Prot
    Q76N89
    Conserved Domains (5) summary
    cd08691
    Location:205341
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:830861
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:12741603
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:12501604
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam16562
    Location:65184
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
  2. XM_017011890.1XP_016867379.1  E3 ubiquitin-protein ligase HECW1 isoform X14

  3. XM_005249665.4XP_005249722.1  E3 ubiquitin-protein ligase HECW1 isoform X5

    See identical proteins and their annotated locations for XP_005249722.1

    Conserved Domains (5) summary
    cd08691
    Location:205341
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:831862
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:12751604
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:12511605
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam16562
    Location:65184
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
  4. XM_006715670.3XP_006715733.1  E3 ubiquitin-protein ligase HECW1 isoform X3

    Conserved Domains (5) summary
    cd08691
    Location:206342
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:832863
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:12761605
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:12521606
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam16562
    Location:66185
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
  5. XM_006715671.3XP_006715734.1  E3 ubiquitin-protein ligase HECW1 isoform X4

    Conserved Domains (5) summary
    cd08691
    Location:206342
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:831862
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:12751604
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:12511605
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam16562
    Location:66185
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
  6. XM_006715673.3XP_006715736.1  E3 ubiquitin-protein ligase HECW1 isoform X10

    Conserved Domains (6) summary
    cd08691
    Location:206342
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:9871018
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:12411570
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:12171571
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:800828
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam16562
    Location:66185
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
  7. XM_017011885.1XP_016867374.1  E3 ubiquitin-protein ligase HECW1 isoform X5

    Conserved Domains (5) summary
    cd08691
    Location:205341
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:831862
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:12751604
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:12511605
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam16562
    Location:65184
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
  8. XM_017011883.2XP_016867372.1  E3 ubiquitin-protein ligase HECW1 isoform X1

  9. XM_017011882.1XP_016867371.1  E3 ubiquitin-protein ligase HECW1 isoform X1

  10. XM_017011887.1XP_016867376.1  E3 ubiquitin-protein ligase HECW1 isoform X7

  11. XM_017011884.1XP_016867373.1  E3 ubiquitin-protein ligase HECW1 isoform X2

    Conserved Domains (5) summary
    cd08691
    Location:237373
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:862893
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:13061635
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:12821636
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam16562
    Location:97216
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
  12. XM_017011888.1XP_016867377.1  E3 ubiquitin-protein ligase HECW1 isoform X8

  13. XM_017011889.1XP_016867378.1  E3 ubiquitin-protein ligase HECW1 isoform X11

    UniProtKB/Swiss-Prot
    Q76N89
    Conserved Domains (6) summary
    cd08691
    Location:205341
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:9861017
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:12401569
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:12161570
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:799827
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam16562
    Location:65184
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
  14. XM_011515220.3XP_011513522.1  E3 ubiquitin-protein ligase HECW1 isoform X5

    See identical proteins and their annotated locations for XP_011513522.1

    Conserved Domains (5) summary
    cd08691
    Location:205341
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:831862
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:12751604
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:12511605
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam16562
    Location:65184
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
  15. XM_011515223.2XP_011513525.1  E3 ubiquitin-protein ligase HECW1 isoform X9

    See identical proteins and their annotated locations for XP_011513525.1

    Conserved Domains (5) summary
    cd08691
    Location:184320
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:810841
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:12541583
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:12301584
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam16562
    Location:44163
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
  16. XM_011515222.2XP_011513524.1  E3 ubiquitin-protein ligase HECW1 isoform X9

    See identical proteins and their annotated locations for XP_011513524.1

    Conserved Domains (5) summary
    cd08691
    Location:184320
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:810841
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:12541583
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:12301584
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam16562
    Location:44163
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
  17. XM_011515224.2XP_011513526.1  E3 ubiquitin-protein ligase HECW1 isoform X9

    See identical proteins and their annotated locations for XP_011513526.1

    Conserved Domains (5) summary
    cd08691
    Location:184320
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:810841
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:12541583
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:12301584
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam16562
    Location:44163
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
  18. XM_011515225.2XP_011513527.2  E3 ubiquitin-protein ligase HECW1 isoform X12

  19. XM_011515226.3XP_011513528.1  E3 ubiquitin-protein ligase HECW1 isoform X13

    Conserved Domains (4) summary
    cd08691
    Location:35171
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:661692
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:11051434
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:10811435
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
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