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FOXS1 forkhead box S1 [ Homo sapiens (human) ]

Gene ID: 2307, updated on 11-Jun-2021

Summary

Official Symbol
FOXS1provided by HGNC
Official Full Name
forkhead box S1provided by HGNC
Primary source
HGNC:HGNC:3735
See related
Ensembl:ENSG00000179772 MIM:602939
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKHL18; FREAC10
Summary
The forkhead family of transcription factors belongs to the winged helix class of DNA-binding proteins. The protein encoded by this intronless gene contains a forkhead domain and is found predominantly in aorta and kidney. The function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See FOXS1 in Genome Data Viewer
Location:
20q11.21
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (31844303..31845604, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30432106..30433407, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene TPX2 microtubule nucleation factor Neighboring gene myosin light chain kinase 2 Neighboring gene dual specificity phosphatase 15 Neighboring gene tubulin tyrosine ligase like 9 Neighboring gene Sharpr-MPRA regulatory region 918 Neighboring gene RNA, U1 small nuclear 94, pseudogene

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC4544

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in blood vessel development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
forkhead box protein S1
Names
FREAC-10
forkhead-like 18 protein
forkhead-related activator 10
forkhead-related transcription factor 10
forkhead-related transcription factor FREAC-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004118.4NP_004109.1  forkhead box protein S1

    See identical proteins and their annotated locations for NP_004109.1

    Status: REVIEWED

    Source sequence(s)
    BC013408
    Consensus CDS
    CCDS13192.1
    UniProtKB/Swiss-Prot
    O43638
    Related
    ENSP00000365145.3, ENST00000375978.5
    Conserved Domains (2) summary
    pfam00250
    Location:18103
    Forkhead; Forkhead domain
    cl26386
    Location:116313
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    31844303..31845604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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