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Zfyve9 zinc finger, FYVE domain containing 9 [ Mus musculus (house mouse) ]

Gene ID: 230597, updated on 2-Nov-2024

Summary

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Official Symbol
Zfyve9provided by MGI
Official Full Name
zinc finger, FYVE domain containing 9provided by MGI
Primary source
MGI:MGI:2652838
See related
Ensembl:ENSMUSG00000034557 AllianceGenome:MGI:2652838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NSP; SARA; Madhip; SMADIP
Summary
Predicted to enable 1-phosphatidylinositol binding activity; SMAD binding activity; and protein domain specific binding activity. Predicted to be involved in endosomal transport and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of protein-containing complex. Predicted to be active in early endosome membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human ZFYVE9 (zinc finger FYVE-type containing 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 7.6), cortex adult (RPKM 4.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Zfyve9 in Genome Data Viewer
Location:
4 C7; 4 50.64 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (108494663..108642514, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (108637466..108781269, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1036 Neighboring gene PRP38 pre-mRNA processing factor 38 (yeast) domain containing A Neighboring gene origin recognition complex, subunit 1 Neighboring gene predicted gene 12743 Neighboring gene coiled-coil and C2 domain containing 1B Neighboring gene ribosomal protein L9 pseudogene Neighboring gene predicted gene, 53266 Neighboring gene STARR-seq mESC enhancer starr_11051 Neighboring gene STARR-seq mESC enhancer starr_11052 Neighboring gene basic transcription factor 3-like 4 Neighboring gene STARR-positive B cell enhancer mm9_chr4:108520274-108520575 Neighboring gene thioredoxin domain containing 12 (endoplasmic reticulum) Neighboring gene KTI12 homolog, chromatin associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sustained BMP signaling in osteoblasts stimulates bone formation by promoting angiogenesis and osteoblast differentiation. Zhang F, et al. J Bone Miner Res, 2009 Jul. PMID 19257813, Free PMC Article
  2. CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells. Lewis ND, et al. PLoS One, 2014. PMID 25170619, Free PMC Article
  3. The FYVE domain of Smad Anchor for Receptor Activation (SARA) is required to prevent skin carcinogenesis, but not in mouse development. Chang HM, et al. PLoS One, 2014. PMID 25170969, Free PMC Article
  4. SARA regulates neuronal migration during neocortical development through L1 trafficking. Mestres I, et al. Development, 2016 Sep 1. PMID 27471254, Free PMC Article
  5. Cytoplasmic PML function in TGF-beta signalling. Lin HK, et al. Nature, 2004 Sep 9. PMID 15356634

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • E030027L17

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger FYVE domain-containing protein 9
Names
MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347163.2 → NP_001334092.1  zinc finger FYVE domain-containing protein 9 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL607070, AL626783, AL671909
    Consensus CDS
    CCDS84772.1
    UniProtKB/TrEMBL
    A2A8R0
    Conserved Domains (3) summary
    cd15729
    Location:662 → 729
    FYVE_endofin; FYVE domain found in endofin and similar proteins
    pfam11409
    Location:745 → 783
    SARA; Smad anchor for receptor activation (SARA)
    pfam11979
    Location:1020 → 1372
    DUF3480; Domain of unknown function (DUF3480)

  2. NM_001384118.1 → NP_001371047.1  zinc finger FYVE domain-containing protein 9 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL607070, AL626783, AL671909
    UniProtKB/TrEMBL
    A2A8R0
    Related
    ENSMUSP00000102268.2, ENSMUST00000106657.8
    Conserved Domains (3) summary
    cd15729
    Location:662 → 729
    FYVE_endofin; FYVE domain found in endofin and similar proteins
    pfam11409
    Location:745 → 783
    SARA; Smad anchor for receptor activation (SARA)
    pfam11979
    Location:1020 → 1372
    DUF3480; Domain of unknown function (DUF3480)

  3. NM_001426209.1 → NP_001413138.1  zinc finger FYVE domain-containing protein 9 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL607070, AL626783, AL671909
    UniProtKB/TrEMBL
    A8Y5G5
    Related
    ENSMUSP00000102269.2, ENSMUST00000106658.8

  4. NM_001426210.1 → NP_001413139.1  zinc finger FYVE domain-containing protein 9 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL607070, AL626783, AL671909

  5. NM_001426211.1 → NP_001413140.1  zinc finger FYVE domain-containing protein 9 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL607070, AL626783, AL671909

  6. NM_183300.4 → NP_899123.2  zinc finger FYVE domain-containing protein 9 isoform 2

    See identical proteins and their annotated locations for NP_899123.2

    Status: VALIDATED

    Source sequence(s)
    AL607070, AL626783, AL671909
    Consensus CDS
    CCDS38834.1
    UniProtKB/TrEMBL
    A0S860
    Related
    ENSMUSP00000039852.8, ENSMUST00000042185.8
    Conserved Domains (3) summary
    pfam11409
    Location:54 → 92
    SARA; Smad anchor for receptor activation (SARA)
    pfam11979
    Location:329 → 681
    DUF3480; Domain of unknown function (DUF3480)
    cl22851
    Location:7 → 38
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    108494663..108642514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502986.5 → XP_006503049.1  zinc finger FYVE domain-containing protein 9 isoform X1

    Conserved Domains (3) summary
    cd15729
    Location:696 → 763
    FYVE_endofin; FYVE domain found in endofin and similar proteins
    pfam11409
    Location:779 → 817
    SARA; Smad anchor for receptor activation (SARA)
    pfam11979
    Location:1054 → 1406
    DUF3480; Domain of unknown function (DUF3480)

  2. XM_006502988.5 → XP_006503051.1  zinc finger FYVE domain-containing protein 9 isoform X3

    Conserved Domains (2) summary
    cd15729
    Location:696 → 763
    FYVE_endofin; FYVE domain found in endofin and similar proteins
    pfam11979
    Location:995 → 1347
    DUF3480; Domain of unknown function (DUF3480)

  3. XM_030253438.2 → XP_030109298.1  zinc finger FYVE domain-containing protein 9 isoform X2

    Conserved Domains (3) summary
    cd15729
    Location:696 → 763
    FYVE_endofin; FYVE domain found in endofin and similar proteins
    pfam11409
    Location:779 → 817
    SARA; Smad anchor for receptor activation (SARA)
    pfam11979
    Location:1054 → 1379
    DUF3480; Domain of unknown function (DUF3480)
Nucleotide Protein Strain
Heading Accession and Version

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