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XPO7 exportin 7 [ Homo sapiens (human) ]

Gene ID: 23039, updated on 7-Oct-2018

Summary

Official Symbol
XPO7provided by HGNC
Official Full Name
exportin 7provided by HGNC
Primary source
HGNC:HGNC:14108
See related
Ensembl:ENSG00000130227 MIM:606140; Vega:OTTHUMG00000163789
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EXP7; RANBP16
Summary
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
Expression
Ubiquitous expression in testis (RPKM 19.6), thyroid (RPKM 15.0) and 25 other tissues See more
Orthologs

Genomic context

See XPO7 in Genome Data Viewer
Location:
8p21.3
Exon count:
30
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (21919669..22006585)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (21777180..21864096)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986923 Neighboring gene docking protein 2 Neighboring gene VISTA enhancer hs783 Neighboring gene nucleophosmin/nucleoplasmin 2 Neighboring gene VISTA enhancer hs782 Neighboring gene fibroblast growth factor 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0745

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Ran GTPase binding IEA
Inferred from Electronic Annotation
more info
 
nuclear export signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear export signal receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
exportin-7
Names
RAN binding protein 16

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100161.1NP_001093631.1  exportin-7 isoform a

    Status: VALIDATED

    Source sequence(s)
    AF064729, BC014219, CN479571, DB460798, DC332379
    Conserved Domains (2) summary
    smart00913
    Location:3096
    IBN_N; Importin-beta N-terminal domain
    cl26694
    Location:29314
    Xpo1; Exportin 1-like protein
  2. NM_001362802.1NP_001349731.1  exportin-7 isoform d

    Status: VALIDATED

    Source sequence(s)
    AF064729, BC014219, CN479571, DB460798
    Conserved Domains (2) summary
    smart00913
    Location:3096
    IBN_N; Importin-beta N-terminal domain
    cl26694
    Location:29283
    Xpo1; Exportin 1-like protein
  3. NM_015024.4NP_055839.3  exportin-7 isoform b

    See identical proteins and their annotated locations for NP_055839.3

    Status: VALIDATED

    Source sequence(s)
    AF064729, BC014219, CN479571, DB460798
    Consensus CDS
    CCDS47818.1
    UniProtKB/Swiss-Prot
    Q9UIA9
    Related
    ENSP00000252512.9, OTTHUMP00000224893, ENST00000252512.13, OTTHUMT00000375494
    Conserved Domains (2) summary
    smart00913
    Location:3096
    IBN_N; Importin-beta N-terminal domain
    cl26694
    Location:29305
    Xpo1; Exportin 1-like protein

RNA

  1. NR_156173.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091171, AF064729, BC014219, CN479571, DB460798

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    21919669..22006585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013245.1XP_016868734.1  exportin-7 isoform X2

    Conserved Domains (2) summary
    smart00913
    Location:3096
    IBN_N; Importin-beta N-terminal domain
    cl26694
    Location:29314
    Xpo1; Exportin 1-like protein
  2. XM_024447111.1XP_024302879.1  exportin-7 isoform X5

    Conserved Domains (2) summary
    smart00913
    Location:3096
    IBN_N; Importin-beta N-terminal domain
    cl26694
    Location:29283
    Xpo1; Exportin 1-like protein
  3. XM_024447108.1XP_024302876.1  exportin-7 isoform X1

    Conserved Domains (2) summary
    smart00913
    Location:3399
    IBN_N; Importin-beta N-terminal domain
    cl26694
    Location:32317
    Xpo1; Exportin 1-like protein
  4. XM_024447109.1XP_024302877.1  exportin-7 isoform X3

    Related
    ENSP00000410249.3, ENST00000433566.8
    Conserved Domains (2) summary
    smart00913
    Location:3399
    IBN_N; Importin-beta N-terminal domain
    cl26694
    Location:32308
    Xpo1; Exportin 1-like protein
  5. XM_024447110.1XP_024302878.1  exportin-7 isoform X4

    Conserved Domains (2) summary
    smart00913
    Location:3399
    IBN_N; Importin-beta N-terminal domain
    cl26694
    Location:32286
    Xpo1; Exportin 1-like protein

RNA

  1. XR_001745502.1 RNA Sequence

  2. XR_002956623.1 RNA Sequence

  3. XR_002956624.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001100162.1: Suppressed sequence

    Description
    NM_001100162.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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