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FOXJ1 forkhead box J1 [ Homo sapiens (human) ]

Gene ID: 2302, updated on 27-Jun-2020

Summary

Official Symbol
FOXJ1provided by HGNC
Official Full Name
forkhead box J1provided by HGNC
Primary source
HGNC:HGNC:3816
See related
Ensembl:ENSG00000129654 MIM:602291
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HFH4; HFH-4; CILD43; FKHL13
Summary
This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry. Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.[provided by RefSeq, Sep 2009]
Expression
Biased expression in lung (RPKM 6.3), testis (RPKM 5.4) and 8 other tissues See more
Orthologs

Genomic context

See FOXJ1 in Genome Data Viewer
Location:
17q25.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (76136333..76141245, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74132414..74137380, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene exocyst complex component 7 Neighboring gene microRNA 6868 Neighboring gene uncharacterized LOC101928447 Neighboring gene RNF157 antisense RNA 1 Neighboring gene ring finger protein 157 Neighboring gene ATP synthase membrane subunit g pseudogene 6 Neighboring gene activating transcription factor 4 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC35202

Gene Ontology Provided by GOA

Process Evidence Code Pubs
actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
axoneme assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
brain development NAS
Non-traceable Author Statement
more info
PubMed 
cellular protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
central tolerance induction ISS
Inferred from Sequence or Structural Similarity
more info
 
ciliary basal body organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelium development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
establishment of apical/basal cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
glomerular parietal epithelial cell development IEP
Inferred from Expression Pattern
more info
PubMed 
heart development IEA
Inferred from Electronic Annotation
more info
 
humoral immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
left/right pattern formation IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
 
lung epithelium development IEP
Inferred from Expression Pattern
more info
PubMed 
lung epithelium development NAS
Non-traceable Author Statement
more info
PubMed 
metanephric part of ureteric bud development IEP
Inferred from Expression Pattern
more info
PubMed 
motile cilium assembly IEA
Inferred from Electronic Annotation
more info
 
negative regulation of B cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of T cell differentiation in thymus ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of germinal center formation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of humoral immune response mediated by circulating immunoglobulin ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-6 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
pattern specification process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of central B cell tolerance induction ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of lung ciliated cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
spermatogenesis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
forkhead box protein J1
Names
fork head homologue 4
forkhead transcription factor HFH-4
forkhead-like 13
forkhead-related protein FKHL13
hepatocyte nuclear factor 3 forkhead homolog 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013345.1 RefSeqGene

    Range
    5055..9967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001454.4NP_001445.2  forkhead box protein J1

    See identical proteins and their annotated locations for NP_001445.2

    Status: REVIEWED

    Source sequence(s)
    BC046460
    Consensus CDS
    CCDS32739.1
    UniProtKB/Swiss-Prot
    Q92949
    UniProtKB/TrEMBL
    A0A024R8P1
    Related
    ENSP00000323880.4, ENST00000322957.7
    Conserved Domains (1) summary
    pfam00250
    Location:121205
    Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    76136333..76141245 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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