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GOLGA8A golgin A8 family member A [ Homo sapiens (human) ]

Gene ID: 23015, updated on 16-Jul-2021

Summary

Official Symbol
GOLGA8Aprovided by HGNC
Official Full Name
golgin A8 family member Aprovided by HGNC
Primary source
HGNC:HGNC:31972
See related
Ensembl:ENSG00000175265 MIM:616180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GM88; FAP286; CFAP286; GOLGA8B
Summary
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked, flattened membrane sacs referred to as cisternae. Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins constitute a family of proteins which are localized to the Golgi. This gene encodes a golgin which structurally resembles its family member GOLGA2, suggesting that they may share a similar function. There are many similar copies of this gene on chromosome 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Expression
Ubiquitous expression in thyroid (RPKM 77.6), testis (RPKM 53.7) and 24 other tissues See more
Orthologs
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Genomic context

See GOLGA8A in Genome Data Viewer
Location:
15q14
Exon count:
24
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (34379068..34437808, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (34671269..34730009, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene lysophosphatidylcholine acyltransferase 4 Neighboring gene actin gamma 1 pseudogene 15 Neighboring gene microRNA 1233-1 Neighboring gene amyloid beta precursor protein binding family A member 2 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein L pseudogene 2 Neighboring gene fascin actin-bundling protein 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
is_active_in Golgi cis cisterna IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in Golgi cisterna membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
golgin subfamily A member 8A
Names
88 kDa Golgi matrix protein
88-kDa golgi protein
GM88 autoantigen
Golgin subfamily A member 8B
golgi autoantigen, golgin subfamily a, 8A
golgin-67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368071.2NP_001355000.1  golgin subfamily A member 8A isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variant 4, encodes isoform 2.
    Source sequence(s)
    AC025678
  2. NM_001368072.2NP_001355001.1  golgin subfamily A member 8A isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variant 3, encodes isoform 2.
    Source sequence(s)
    AC025678
  3. NM_001386893.1NP_001373822.1  golgin subfamily A member 8A isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1 and 7, encodes isoform 1.
    Source sequence(s)
    AC025678
    Conserved Domains (3) summary
    TIGR02168
    Location:78439
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15070
    Location:218397
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:558603
    GM130_C; GM130 C-terminal binding motif
  4. NM_001386895.1NP_001373824.1  golgin subfamily A member 8A isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 1 and 6, encodes isoform 1.
    Source sequence(s)
    AC025678
    Conserved Domains (3) summary
    TIGR02168
    Location:78439
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15070
    Location:218397
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:558603
    GM130_C; GM130 C-terminal binding motif
  5. NM_181077.5NP_851422.1  golgin subfamily A member 8A isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC025678
    Consensus CDS
    CCDS10038.1
    UniProtKB/Swiss-Prot
    A7E2F4
    Related
    ENSP00000352111.4, ENST00000359187.5
    Conserved Domains (3) summary
    TIGR02168
    Location:78439
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15070
    Location:218397
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:558603
    GM130_C; GM130 C-terminal binding motif

RNA

  1. NR_027409.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of an alternate upstream promoter, contains additional 5' exons, and retains an intron, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC025678
  2. NR_164784.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025678
    Related
    ENST00000473125.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    34379068..34437808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_015003.4: Suppressed sequence

    Description
    NM_015003.4: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
  2. NM_181076.2: Suppressed sequence

    Description
    NM_181076.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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