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TTC39A tetratricopeptide repeat domain 39A [ Homo sapiens (human) ]

Gene ID: 22996, updated on 5-Sep-2021

Summary

Official Symbol
TTC39Aprovided by HGNC
Official Full Name
tetratricopeptide repeat domain 39Aprovided by HGNC
Primary source
HGNC:HGNC:18657
See related
Ensembl:ENSG00000085831
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEME-6; C1orf34
Expression
Broad expression in testis (RPKM 15.4), colon (RPKM 9.3) and 14 other tissues See more
Orthologs
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Genomic context

See TTC39A in Genome Data Viewer
Location:
1p32.3
Exon count:
25
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (51287258..51345116, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (51752930..51810788, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mitochondrial import receptor subunit TOM5 homolog pseudogene Neighboring gene long intergenic non-protein coding RNA 1562 Neighboring gene ring finger protein 11 Neighboring gene ribosomal protein S2 pseudogene 8 Neighboring gene uncharacterized LOC105378717 Neighboring gene TTC39A antisense RNA 1 Neighboring gene proteasome 26S subunit, non-ATPase 7 pseudogene Neighboring gene epidermal growth factor receptor pathway substrate 15 Neighboring gene RNA, U6 small nuclear 877, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0452

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
tetratricopeptide repeat protein 39A
Names
TPR repeat protein 39A
differentially expressed in MCF7 with estradiol protein 6
testicular tissue protein Li 213

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080494.3NP_001073963.1  tetratricopeptide repeat protein 39A isoform 2

    See identical proteins and their annotated locations for NP_001073963.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL162430, AL671986
    Consensus CDS
    CCDS44144.1
    UniProtKB/Swiss-Prot
    Q5SRH9
    UniProtKB/TrEMBL
    A0A140VJY6
    Related
    ENSP00000360815.5, ENST00000371750.9
    Conserved Domains (1) summary
    pfam10300
    Location:29483
    DUF3808; Protein of unknown function (DUF3808)
  2. NM_001144832.2NP_001138304.1  tetratricopeptide repeat protein 39A isoform 1

    See identical proteins and their annotated locations for NP_001138304.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AF007170, BC028374, CX788693, DA871604
    Consensus CDS
    CCDS44143.1
    UniProtKB/Swiss-Prot
    Q5SRH9
    Related
    ENSP00000406144.2, ENST00000413473.6
    Conserved Domains (1) summary
    pfam10300
    Location:32486
    DUF3808; Protein of unknown function (DUF3808)
  3. NM_001297662.2NP_001284591.1  tetratricopeptide repeat protein 39A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple differences, compared to variant 1, including initiation of translation at an alternate start codon. The encoded isoform (3) has distinct N- and C- termini and is shorter than isoform 1.
    Source sequence(s)
    AK000220
    Consensus CDS
    CCDS76163.1
    UniProtKB/TrEMBL
    A0A0A0MRQ0
    Related
    ENSP00000360812.3, ENST00000371747.7
    Conserved Domains (1) summary
    pfam10300
    Location:28420
    DUF3808; Protein of unknown function (DUF3808)
  4. NM_001297663.2NP_001284592.1  tetratricopeptide repeat protein 39A isoform 4

    See identical proteins and their annotated locations for NP_001284592.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL162430, AL671986
    UniProtKB/Swiss-Prot
    Q5SRH9
    Related
    ENSP00000505859.1, ENST00000680483.1
    Conserved Domains (1) summary
    pfam10300
    Location:28482
    DUF3808; Protein of unknown function (DUF3808)
  5. NM_001297664.1NP_001284593.1  tetratricopeptide repeat protein 39A isoform 5

    See identical proteins and their annotated locations for NP_001284593.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AF007170, AK298019, BC028374, BI761577
    Consensus CDS
    CCDS72789.1
    UniProtKB/Swiss-Prot
    Q5SRH9
    UniProtKB/TrEMBL
    B7Z4W9, D3DQ30
    Related
    ENSP00000262675.7, ENST00000262675.11
    Conserved Domains (1) summary
    pfam10300
    Location:1455
    DUF3808; Protein of unknown function (DUF3808)
  6. NM_001297665.1NP_001284594.1  tetratricopeptide repeat protein 39A isoform 6

    See identical proteins and their annotated locations for NP_001284594.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains multiple differences, compared to variant 1, including initiation of translation at an alternate start codon. The encoded isoform (6) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AF007170, AK000220, BC028374, HY029911
    Consensus CDS
    CCDS72790.1
    UniProtKB/Swiss-Prot
    Q5SRH9
    Related
    ENSP00000393952.2, ENST00000447632.6
    Conserved Domains (1) summary
    pfam10300
    Location:29518
    DUF3808; Protein of unknown function (DUF3808)
  7. NM_001297666.1NP_001284595.1  tetratricopeptide repeat protein 39A isoform 7

    See identical proteins and their annotated locations for NP_001284595.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a large portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (7) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AF007170, BC004399, BQ227134
    Consensus CDS
    CCDS76162.1
    UniProtKB/Swiss-Prot
    Q5SRH9
    Related
    ENSP00000431228.1, ENST00000530004.5
    Conserved Domains (1) summary
    pfam10300
    Location:1126
    DUF3808; Protein of unknown function (DUF3808)
  8. NM_001297667.1NP_001284596.1  tetratricopeptide repeat protein 39A isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a large portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (8) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AF007170, BQ227134
    UniProtKB/Swiss-Prot
    Q5SRH9
    Conserved Domains (1) summary
    pfam10300
    Location:159
    DUF3808; Protein of unknown function (DUF3808)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    51287258..51345116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541050.2XP_011539352.1  tetratricopeptide repeat protein 39A isoform X3

    Related
    ENSP00000405803.2, ENST00000439482.6
    Conserved Domains (1) summary
    pfam10300
    Location:28517
    DUF3808; Protein of unknown function (DUF3808)
  2. XM_011541048.2XP_011539350.1  tetratricopeptide repeat protein 39A isoform X1

    Conserved Domains (1) summary
    pfam10300
    Location:32521
    DUF3808; Protein of unknown function (DUF3808)
  3. XM_011541053.2XP_011539355.1  tetratricopeptide repeat protein 39A isoform X5

    See identical proteins and their annotated locations for XP_011539355.1

    Conserved Domains (1) summary
    pfam10300
    Location:1490
    DUF3808; Protein of unknown function (DUF3808)
  4. XM_017000715.2XP_016856204.1  tetratricopeptide repeat protein 39A isoform X7

    UniProtKB/TrEMBL
    D3DQ30
    Conserved Domains (1) summary
    pfam10300
    Location:1455
    DUF3808; Protein of unknown function (DUF3808)
  5. XM_005270644.2XP_005270701.1  tetratricopeptide repeat protein 39A isoform X6

    Conserved Domains (1) summary
    pfam10300
    Location:25479
    DUF3808; Protein of unknown function (DUF3808)
  6. XM_006710471.2XP_006710534.1  tetratricopeptide repeat protein 39A isoform X4

    Conserved Domains (1) summary
    pfam10300
    Location:25514
    DUF3808; Protein of unknown function (DUF3808)
  7. XM_011541051.2XP_011539353.1  tetratricopeptide repeat protein 39A isoform X5

    See identical proteins and their annotated locations for XP_011539353.1

    Conserved Domains (1) summary
    pfam10300
    Location:1490
    DUF3808; Protein of unknown function (DUF3808)
  8. XM_011541052.2XP_011539354.1  tetratricopeptide repeat protein 39A isoform X5

    See identical proteins and their annotated locations for XP_011539354.1

    Related
    ENSP00000505465.1, ENST00000680290.1
    Conserved Domains (1) summary
    pfam10300
    Location:1490
    DUF3808; Protein of unknown function (DUF3808)
  9. XM_011541054.2XP_011539356.1  tetratricopeptide repeat protein 39A isoform X7

    See identical proteins and their annotated locations for XP_011539356.1

    UniProtKB/TrEMBL
    D3DQ30
    Related
    ENSP00000388995.2, ENST00000422925.6
    Conserved Domains (1) summary
    pfam10300
    Location:1455
    DUF3808; Protein of unknown function (DUF3808)
  10. XM_011541049.2XP_011539351.1  tetratricopeptide repeat protein 39A isoform X2

    Conserved Domains (1) summary
    pfam10300
    Location:30519
    DUF3808; Protein of unknown function (DUF3808)
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