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Znhit6 zinc finger, HIT type 6 [ Mus musculus (house mouse) ]

Gene ID: 229937, updated on 2-Nov-2024

Summary

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Official Symbol
Znhit6provided by MGI
Official Full Name
zinc finger, HIT type 6provided by MGI
Primary source
MGI:MGI:1916996
See related
Ensembl:ENSMUSG00000074182 AllianceGenome:MGI:1916996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410019A14Rik
Summary
Predicted to enable ATPase binding activity; TFIID-class transcription factor complex binding activity; and identical protein binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); protein-containing complex assembly; and snoRNA localization. Predicted to be part of pre-snoRNP complex. Predicted to be active in nucleus. Orthologous to human ZNHIT6 (zinc finger HIT-type containing 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 7.2), CNS E14 (RPKM 4.5) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Znhit6 in Genome Data Viewer
Location:
3 H2; 3 69.89 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (145281943..145313570)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (145576201..145605245)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1637 Neighboring gene STARR-positive B cell enhancer mm9_chr3:144794197-144794498 Neighboring gene outer dense fiber of sperm tails 2-like Neighboring gene collagen, type XXIV, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_09192 Neighboring gene predicted gene, 35133 Neighboring gene STARR-seq mESC enhancer starr_09193 Neighboring gene STARR-seq mESC enhancer starr_09194 Neighboring gene STARR-seq mESC enhancer starr_09195 Neighboring gene STARR-seq mESC enhancer starr_09196 Neighboring gene STARR-seq mESC enhancer starr_09197 Neighboring gene STARR-seq mESC enhancer starr_09198 Neighboring gene predicted gene, 40164 Neighboring gene cellular communication network factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding IEA
Inferred from Electronic Annotation
more info
  
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables TFIID-class transcription factor complex binding IEA
Inferred from Electronic Annotation
more info
  
enables TFIID-class transcription factor complex binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in box C/D snoRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in box C/D snoRNP assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in box C/D snoRNP assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein complex oligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in snoRNA localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snoRNA localization IEA
Inferred from Electronic Annotation
more info
  
involved_in snoRNA localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of pre-snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of pre-snoRNP complex IEA
Inferred from Electronic Annotation
more info
  
part_of pre-snoRNP complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
box C/D snoRNA protein 1
Names
zinc finger HIT domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081094.1 → NP_001074563.1  box C/D snoRNA protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001074563.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC136729
    Consensus CDS
    CCDS38662.1
    UniProtKB/Swiss-Prot
    B2RW16, Q3TG81, Q3UFB2
    Related
    ENSMUSP00000096136.5, ENSMUST00000098534.9
    Conserved Domains (1) summary
    pfam04438
    Location:210 → 237
    zf-HIT; HIT zinc finger

  2. NM_001346521.1 → NP_001333450.1  box C/D snoRNA protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AA509476, AK168844, BQ031699, BY141293
    Consensus CDS
    CCDS84683.1
    UniProtKB/Swiss-Prot
    Q3UFB2
    Related
    ENSMUSP00000143306.2, ENSMUST00000199033.5
    Conserved Domains (1) summary
    pfam04438
    Location:42 → 69
    zf-HIT; HIT zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    145281943..145313570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501437.5 → XP_006501500.1  box C/D snoRNA protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006501500.1

    Conserved Domains (1) summary
    pfam04438
    Location:66 → 93
    zf-HIT; HIT zinc finger

  2. XM_006501436.5 → XP_006501499.1  box C/D snoRNA protein 1 isoform X1

    Conserved Domains (1) summary
    pfam04438
    Location:210 → 237
    zf-HIT; HIT zinc finger

  3. XM_006501439.3 → XP_006501502.1  box C/D snoRNA protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006501502.1

    UniProtKB/Swiss-Prot
    Q3UFB2
    Conserved Domains (1) summary
    pfam04438
    Location:42 → 69
    zf-HIT; HIT zinc finger

RNA

  1. XR_004941318.1 RNA Sequence

  2. XR_375523.4 RNA Sequence

  3. XR_004941319.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UFB2.2 GenPept UniProtKB/Swiss-Prot:Q3UFB2

Gene LinkOut

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