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MYH15 myosin heavy chain 15 [ Homo sapiens (human) ]

Gene ID: 22989, updated on 1-Jun-2020

Summary

Official Symbol
MYH15provided by HGNC
Official Full Name
myosin heavy chain 15provided by HGNC
Primary source
HGNC:HGNC:31073
See related
Ensembl:ENSG00000144821 MIM:609929
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See MYH15 in Genome Data Viewer
Location:
3q13.13
Exon count:
44
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (108380368..108549462, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108099216..108248169, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 57 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 17 Neighboring gene HERV-H LTR-associating 2 Neighboring gene ribosomal protein L13 pseudogene 8 Neighboring gene cellular inhibitor of PP2A Neighboring gene DAZ interacting zinc finger protein 3 Neighboring gene uncharacterized LOC105374033

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
motor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
extraocular skeletal muscle development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
myofibril IEA
Inferred from Electronic Annotation
more info
 
myosin complex IEA
Inferred from Electronic Annotation
more info
 
myosin filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myosin-15
Names
myosin, heavy polypeptide 15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014981.2NP_055796.1  myosin-15 precursor

    See identical proteins and their annotated locations for NP_055796.1

    Status: VALIDATED

    Source sequence(s)
    AB023217, AC069499, AC135308, AK126801
    Consensus CDS
    CCDS43127.1
    UniProtKB/Swiss-Prot
    Q9Y2K3
    Related
    ENSP00000273353.3, ENST00000273353.4
    Conserved Domains (7) summary
    cd14929
    Location:117778
    MYSc_Myh15_mammals; class II myosin heavy chain 15, motor domain
    pfam00063
    Location:105778
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8591935
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:5290
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam13094
    Location:10171164
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
    pfam14235
    Location:18641940
    DUF4337; Domain of unknown function (DUF4337)
    cl19511
    Location:14871600
    DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    108380368..108549462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512559.2XP_011510861.1  myosin-15 isoform X1

    See identical proteins and their annotated locations for XP_011510861.1

    UniProtKB/Swiss-Prot
    Q9Y2K3
    Conserved Domains (7) summary
    cd14929
    Location:117778
    MYSc_Myh15_mammals; class II myosin heavy chain 15, motor domain
    pfam00063
    Location:105778
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8591935
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:5290
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam13094
    Location:10171164
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
    pfam14235
    Location:18641940
    DUF4337; Domain of unknown function (DUF4337)
    cl19511
    Location:14871600
    DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
  2. XM_017005922.1XP_016861411.1  myosin-15 isoform X2

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