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MYH15 myosin heavy chain 15 [ Homo sapiens (human) ]

Gene ID: 22989, updated on 4-Nov-2022

Summary

Official Symbol
MYH15provided by HGNC
Official Full Name
myosin heavy chain 15provided by HGNC
Primary source
HGNC:HGNC:31073
See related
Ensembl:ENSG00000144821 MIM:609929; AllianceGenome:HGNC:31073
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable several functions, including ATP binding activity; actin filament binding activity; and calmodulin binding activity. Predicted to be involved in extraocular skeletal muscle development. Located in cytosol and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See MYH15 in Genome Data Viewer
Location:
3q13.13
Exon count:
43
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (108380368..108551072, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (111100157..111230350, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108099215..108229443, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124909405 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 17 Neighboring gene HERV-H LTR-associating 2 Neighboring gene uncharacterized LOC124900545 Neighboring gene Sharpr-MPRA regulatory region 5857 Neighboring gene uncharacterized LOC124909406 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene ribosomal protein L13 pseudogene 8 Neighboring gene cellular inhibitor of PP2A Neighboring gene DAZ interacting zinc finger protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in myofibril IEA
Inferred from Electronic Annotation
more info
 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
myosin-15
Names
myosin, heavy polypeptide 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014981.3NP_055796.2  myosin-15

    Status: VALIDATED

    Source sequence(s)
    AC069499, AC135308
    Consensus CDS
    CCDS43127.2
    UniProtKB/TrEMBL
    A0A8I5KXJ3
    Related
    ENSP00000508967.1, ENST00000693548.1
    Conserved Domains (3) summary
    COG5022
    Location:331440
    COG5022; Myosin heavy chain [General function prediction only]
    TIGR02168
    Location:10731912
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd14929
    Location:97758
    MYSc_Myh15_mammals; class II myosin heavy chain 15, motor domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    108380368..108551072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512559.3XP_011510861.1  myosin-15 isoform X1

    See identical proteins and their annotated locations for XP_011510861.1

    UniProtKB/Swiss-Prot
    Q9Y2K3
    Conserved Domains (7) summary
    cd14929
    Location:117778
    MYSc_Myh15_mammals; class II myosin heavy chain 15, motor domain
    pfam00063
    Location:105778
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8591935
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:5290
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam13094
    Location:10171164
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
    pfam14235
    Location:18641940
    DUF4337; Domain of unknown function (DUF4337)
    cl19511
    Location:14871600
    DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    111100157..111230350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)