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Elapor1 endosome-lysosome associated apoptosis and autophagy regulator 1 [ Mus musculus (house mouse) ]

Gene ID: 229722, updated on 9-Mar-2023

Summary

Official Symbol
Elapor1provided by MGI
Official Full Name
endosome-lysosome associated apoptosis and autophagy regulator 1provided by MGI
Primary source
MGI:MGI:1923930
See related
Ensembl:ENSMUSG00000040412 AllianceGenome:MGI:1923930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Iir; Inceptor; 5330417C22Rik
Summary
Predicted to be involved in autophagosome assembly; cellular response to starvation; and positive regulation of autophagosome assembly. Predicted to act upstream of or within autophagy. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Predicted to colocalize with late endosome; lysosome; and trans-Golgi network. Orthologous to human ELAPOR1 (endosome-lysosome associated apoptosis and autophagy regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 38.0), colon adult (RPKM 28.0) and 8 other tissues See more
Orthologs
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Genomic context

See Elapor1 in Genome Data Viewer
Location:
3; 3 F3
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108362995..108444064, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108455679..108536745, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 2 Neighboring gene predicted gene, 52630 Neighboring gene seryl-aminoacyl-tRNA synthetase Neighboring gene predicted gene, 22942 Neighboring gene predicted gene, 23336 Neighboring gene cilia and flagella associated protein 276 Neighboring gene small Cajal body-specific RNA 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Clone Names

  • KIAA1324

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vacuole organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of vacuole organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with late endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with late endosome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
endosome/lysosome-associated apoptosis and autophagy regulator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033304.2NP_001028476.1  endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 2

    See identical proteins and their annotated locations for NP_001028476.1

    Status: VALIDATED

    Source sequence(s)
    AK139330, AL672200, AL683823, BP763374
    Consensus CDS
    CCDS17761.1
    UniProtKB/Swiss-Prot
    A2AFS3
    Related
    ENSMUSP00000040128.7, ENSMUST00000048012.13
    Conserved Domains (2) summary
    pfam07562
    Location:279315
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl22855
    Location:163295
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  2. NM_001346518.1NP_001333447.1  endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL672200, AL683823, BP763374
    Consensus CDS
    CCDS84664.1
    UniProtKB/TrEMBL
    A0A0A0MQC6
    Related
    ENSMUSP00000102236.4, ENSMUST00000106625.10
  3. NM_001358063.1NP_001344992.1  endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL672200, AL683823, BP763374
    Conserved Domains (1) summary
    cl22855
    Location:265397
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  4. NM_001358064.1NP_001344993.1  endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AL672200, AL683823, BP763374
    Conserved Domains (1) summary
    cl22855
    Location:265397
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  5. NM_001358065.1NP_001344994.1  endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL672200, AL683823, BP763374
    Conserved Domains (1) summary
    cl22855
    Location:163295
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    108362995..108444064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252595.2XP_030108455.1  endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform X2

    Conserved Domains (3) summary
    cd00185
    Location:193228
    TNFRSF; CRD2 [structural motif]
    pfam07562
    Location:279315
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl22855
    Location:163295
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  2. XM_006501415.4XP_006501478.1  endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform X1

    See identical proteins and their annotated locations for XP_006501478.1

    UniProtKB/Swiss-Prot
    A2AFS3
    Conserved Domains (2) summary
    pfam07562
    Location:279315
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl22855
    Location:163295
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  3. XM_006501414.5XP_006501477.1  endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform X1

    See identical proteins and their annotated locations for XP_006501477.1

    UniProtKB/Swiss-Prot
    A2AFS3
    Conserved Domains (2) summary
    pfam07562
    Location:279315
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl22855
    Location:163295
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RNA

  1. XR_004941314.1 RNA Sequence