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ZP1 zona pellucida glycoprotein 1 [ Homo sapiens (human) ]

Gene ID: 22917, updated on 20-Mar-2020

Summary

Official Symbol
ZP1provided by HGNC
Official Full Name
zona pellucida glycoprotein 1provided by HGNC
Primary source
HGNC:HGNC:13187
See related
Ensembl:ENSG00000149506 MIM:195000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OOMD; OOMD1; HEL163
Summary
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility. [provided by RefSeq, May 2014]
Expression
Biased expression in testis (RPKM 1.8), fat (RPKM 0.3) and 2 other tissues See more
Orthologs

Genomic context

See ZP1 in Genome Data Viewer
Location:
11q12.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (60867542..60875693)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60635015..60643164)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369322 Neighboring gene membrane spanning 4-domains A10 Neighboring gene coiled-coil domain containing 86 Neighboring gene prostaglandin D2 receptor 2 Neighboring gene pre-mRNA processing factor 19 Neighboring gene uncharacterized LOC107984333

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC87693

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
binding of sperm to zona pellucida TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
egg coat IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zona pellucida sperm-binding protein 1
Names
epididymis luminal protein 163
zona pellucida glycoprotein 1 (sperm receptor)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034138.1 RefSeqGene

    Range
    5001..13150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_207341.3NP_997224.2  zona pellucida sperm-binding protein 1 precursor

    See identical proteins and their annotated locations for NP_997224.2

    Status: REVIEWED

    Source sequence(s)
    AI208352, AI766401, AP000777, KF455399
    Consensus CDS
    CCDS31572.1
    UniProtKB/Swiss-Prot
    P60852
    UniProtKB/TrEMBL
    V9HWI9
    Related
    ENSP00000278853.5, ENST00000278853.9
    Conserved Domains (3) summary
    smart00018
    Location:234275
    PD; P or trefoil or TFF domain
    smart00241
    Location:279548
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:412547
    Zona_pellucida; Zona pellucida-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    60867542..60875693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544853.2XP_011543155.1  zona pellucida sperm-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543155.1

    Conserved Domains (2) summary
    smart00241
    Location:4255
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:119254
    Zona_pellucida; Zona pellucida-like domain
  2. XM_011544852.2XP_011543154.1  zona pellucida sperm-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543154.1

    Related
    ENST00000537203.5
    Conserved Domains (2) summary
    smart00241
    Location:4255
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:119254
    Zona_pellucida; Zona pellucida-like domain
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