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Slc35c2 solute carrier family 35, member C2 [ Mus musculus (house mouse) ]

Gene ID: 228875, updated on 2-Nov-2024

Summary

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Official Symbol
Slc35c2provided by MGI
Official Full Name
solute carrier family 35, member C2provided by MGI
Primary source
MGI:MGI:2385166
See related
Ensembl:ENSMUSG00000017664 AllianceGenome:MGI:2385166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CGI-15; Ovcov1; D2Wsu58e
Summary
Predicted to enable antiporter activity. Acts upstream of or within negative regulation of gene expression; positive regulation of Notch signaling pathway; and protein O-linked fucosylation. Predicted to be located in nucleoplasm. Predicted to be active in cis-Golgi network and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and gonad. Orthologous to human SLC35C2 (solute carrier family 35 member C2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 63.1), small intestine adult (RPKM 33.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Slc35c2 in Genome Data Viewer
Location:
2 H3; 2 85.53 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165118442..165129808, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165276522..165287888, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cadherin 22 Neighboring gene predicted gene, 36748 Neighboring gene predicted gene, 25569 Neighboring gene engulfment and cell motility 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:165147221-165147404 Neighboring gene STARR-positive B cell enhancer ABC_E418 Neighboring gene zinc finger protein 663 Neighboring gene predicted gene, 29831

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification, molecular characterization, and tissue expression of OVCOV1. Leach RE, et al. Mamm Genome, 2002 Nov. PMID 12461647
  2. In vivo evidence for GDP-fucose transport in the absence of transporter SLC35C1 and putative transporter SLC35C2. Lu L, et al. J Biol Chem, 2023 Dec. PMID 38270391, Free PMC Article
  3. Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene--evidence for a role in apoptosis. Jabbour L, et al. Genomics, 2003 Mar. PMID 12659813
  4. Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells. Lu L, et al. J Biol Chem, 2010 Nov 12. PMID 20837470, Free PMC Article
  5. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that Slc35c2 enhances fucosylation of Notch1.
    Title: Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC18664

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in UDP-glucose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fucosylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein O-linked fucosylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein O-linked fucosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 35 member C2
Names
ovarian cancer overexpressed gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252573.1 → NP_001239502.1  solute carrier family 35 member C2 isoform 1

    See identical proteins and their annotated locations for NP_001239502.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2, 3, 5, and 6 all encode the same isoform (1).
    Source sequence(s)
    AL591430
    Consensus CDS
    CCDS17074.1
    UniProtKB/Swiss-Prot
    Q8VCX2
    UniProtKB/TrEMBL
    Q3U226, Q5GMH2
    Related
    ENSMUSP00000104921.2, ENSMUST00000109298.8
    Conserved Domains (1) summary
    cd21092
    Location:80 → 327
    TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

  2. NM_001252574.1 → NP_001239503.1  solute carrier family 35 member C2 isoform 1

    See identical proteins and their annotated locations for NP_001239503.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (1).
    Source sequence(s)
    AL591430
    Consensus CDS
    CCDS17074.1
    UniProtKB/Swiss-Prot
    Q8VCX2
    UniProtKB/TrEMBL
    Q3U226, Q5GMH2
    Related
    ENSMUSP00000104922.2, ENSMUST00000109299.8
    Conserved Domains (1) summary
    cd21092
    Location:80 → 327
    TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

  3. NM_001252575.1 → NP_001239504.1  solute carrier family 35 member C2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, uses an alternate splice site and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK053180, BB772752, BB849961
    Conserved Domains (1) summary
    pfam03151
    Location:3 → 199
    TPT; Triose-phosphate Transporter family

  4. NM_001363015.1 → NP_001349944.1  solute carrier family 35 member C2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 2, 3, and 6, encodes isoform 1.
    Source sequence(s)
    AL591430
    Consensus CDS
    CCDS17074.1
    UniProtKB/Swiss-Prot
    Q8VCX2
    UniProtKB/TrEMBL
    Q3U226, Q5GMH2
    Related
    ENSMUSP00000017808.8, ENSMUST00000017808.14
    Conserved Domains (1) summary
    cd21092
    Location:80 → 327
    TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

  5. NM_001363016.1 → NP_001349945.1  solute carrier family 35 member C2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 2, 3, and 5, encodes isoform 1.
    Source sequence(s)
    AL591430
    Consensus CDS
    CCDS17074.1
    UniProtKB/Swiss-Prot
    Q8VCX2
    UniProtKB/TrEMBL
    Q3U226, Q5GMH2
    Conserved Domains (1) summary
    cd21092
    Location:80 → 327
    TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

  6. NM_144893.2 → NP_659142.1  solute carrier family 35 member C2 isoform 1

    See identical proteins and their annotated locations for NP_659142.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (1).
    Source sequence(s)
    AK160899, BB772752, BB849961, BE952356
    Consensus CDS
    CCDS17074.1
    UniProtKB/Swiss-Prot
    Q8VCX2
    UniProtKB/TrEMBL
    Q3U226, Q5GMH2
    Related
    ENSMUSP00000104923.3, ENSMUST00000109300.9
    Conserved Domains (1) summary
    cd21092
    Location:80 → 327
    TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    165118442..165129808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499371.4 → XP_006499434.1  solute carrier family 35 member C2 isoform X1

    See identical proteins and their annotated locations for XP_006499434.1

    UniProtKB/Swiss-Prot
    Q8VCX2
    UniProtKB/TrEMBL
    Q3U226, Q5GMH2
    Conserved Domains (1) summary
    cd21092
    Location:80 → 327
    TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

  2. XM_030250667.2 → XP_030106527.1  solute carrier family 35 member C2 isoform X1

    UniProtKB/Swiss-Prot
    Q8VCX2
    UniProtKB/TrEMBL
    Q3U226, Q5GMH2
    Conserved Domains (1) summary
    cd21092
    Location:80 → 327
    TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

  3. XM_030250672.2 → XP_030106532.1  solute carrier family 35 member C2 isoform X1

    UniProtKB/Swiss-Prot
    Q8VCX2
    UniProtKB/TrEMBL
    Q3U226, Q5GMH2
    Conserved Domains (1) summary
    cd21092
    Location:80 → 327
    TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

  4. XM_036161632.1 → XP_036017525.1  solute carrier family 35 member C2 isoform X1

    UniProtKB/Swiss-Prot
    Q8VCX2
    UniProtKB/TrEMBL
    Q3U226, Q5GMH2
    Conserved Domains (1) summary
    cd21092
    Location:80 → 327
    TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

  5. XM_006499372.5 → XP_006499435.1  solute carrier family 35 member C2 isoform X1

    See identical proteins and their annotated locations for XP_006499435.1

    UniProtKB/Swiss-Prot
    Q8VCX2
    UniProtKB/TrEMBL
    Q3U226, Q5GMH2
    Conserved Domains (1) summary
    cd21092
    Location:80 → 327
    TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

  6. XM_006499375.5 → XP_006499438.1  solute carrier family 35 member C2 isoform X1

    See identical proteins and their annotated locations for XP_006499438.1

    UniProtKB/Swiss-Prot
    Q8VCX2
    UniProtKB/TrEMBL
    Q3U226, Q5GMH2
    Conserved Domains (1) summary
    cd21092
    Location:80 → 327
    TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

  7. XM_030250671.2 → XP_030106531.1  solute carrier family 35 member C2 isoform X1

    UniProtKB/Swiss-Prot
    Q8VCX2
    UniProtKB/TrEMBL
    Q3U226, Q5GMH2
    Conserved Domains (1) summary
    cd21092
    Location:80 → 327
    TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

  8. XM_030250673.2 → XP_030106533.1  solute carrier family 35 member C2 isoform X1

    UniProtKB/Swiss-Prot
    Q8VCX2
    UniProtKB/TrEMBL
    Q3U226, Q5GMH2
    Conserved Domains (1) summary
    cd21092
    Location:80 → 327
    TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

RNA

  1. XR_003952694.2 RNA Sequence

  2. XR_001782366.1 RNA Sequence

    Related
    ENSMUST00000132270.8

  3. XR_004940155.1 RNA Sequence

  4. XR_004940156.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCX2.1 GenPept UniProtKB/Swiss-Prot:Q8VCX2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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