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Fitm2 fat storage-inducing transmembrane protein 2 [ Mus musculus (house mouse) ]

Gene ID: 228859, updated on 10-Feb-2024

Summary

Official Symbol
Fitm2provided by MGI
Official Full Name
fat storage-inducing transmembrane protein 2provided by MGI
Primary source
MGI:MGI:2444508
See related
Ensembl:ENSMUSG00000048486 AllianceGenome:MGI:2444508
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fit2; D930001I22Rik
Summary
Enables diacylglycerol binding activity and triglyceride binding activity. Involved in several processes, including cellular triglyceride homeostasis; lipid droplet formation; and positive regulation of sequestering of triglyceride. Acts upstream of or within sequestering of triglyceride. Located in endoplasmic reticulum membrane. Is integral component of endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Orthologous to human FITM2 (fat storage inducing transmembrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 53.0), adrenal adult (RPKM 50.4) and 19 other tissues See more
Orthologs
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Genomic context

See Fitm2 in Genome Data Viewer
Location:
2 H3; 2 84.29 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163310623..163314549, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163468703..163472629, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900093K20 gene Neighboring gene STARR-positive B cell enhancer ABC_E1608 Neighboring gene oxidative stress responsive serine rich 1 Neighboring gene ganglioside-induced differentiation-associated protein 1-like 1 Neighboring gene STARR-seq mESC enhancer starr_06310 Neighboring gene RIKEN cDNA 2310001K24 gene Neighboring gene STARR-positive B cell enhancer ABC_E4516 Neighboring gene R3H domain containing-like Neighboring gene hepatic nuclear factor 4 alpha, opposite strand Neighboring gene hepatic nuclear factor 4, alpha Neighboring gene predicted gene, 25881

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables diacylglycerol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables triglyceride binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty-acyl-CoA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid droplet formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid droplet formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid droplet formation ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid droplet organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipid droplet organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid droplet organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid storage IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipid storage IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of sequestering of triglyceride IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sequestering of triglyceride IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
acyl-coenzyme A diphosphatase FITM2
Names
fat-inducing protein 2
fat-inducing transcript 2
NP_775573.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173397.4NP_775573.1  acyl-coenzyme A diphosphatase FITM2

    See identical proteins and their annotated locations for NP_775573.1

    Status: PROVISIONAL

    Source sequence(s)
    AK043244
    Consensus CDS
    CCDS38315.1
    UniProtKB/Swiss-Prot
    B9EHX3, P59266, Q5BKP7
    Related
    ENSMUSP00000105045.2, ENSMUST00000109418.2
    Conserved Domains (1) summary
    pfam10261
    Location:51234
    Scs3p; Inositol phospholipid synthesis and fat-storage-inducing TM

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    163310623..163314549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)