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ZHX2 zinc fingers and homeoboxes 2 [ Homo sapiens (human) ]

Gene ID: 22882, updated on 6-Jan-2019

Summary

Official Symbol
ZHX2provided by HGNC
Official Full Name
zinc fingers and homeoboxes 2provided by HGNC
Primary source
HGNC:HGNC:18513
See related
Ensembl:ENSG00000178764 MIM:609185
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAF; AFR1
Summary
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 12.8), lymph node (RPKM 11.9) and 25 other tissues See more
Orthologs

Genomic context

See ZHX2 in Genome Data Viewer
Location:
8q24.13
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (122781349..122974515)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (123792510..123986755)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986904 Neighboring gene cyclin dependent kinase 5 pseudogene 1 Neighboring gene derlin 1 Neighboring gene TBC1 domain family member 31 Neighboring gene RNY4 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of behavioral disinhibition.
NHGRI GWA Catalog
Genome-wide association study of antibody response to smallpox vaccine.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0854

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
retinal bipolar neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc fingers and homeoboxes protein 2
Names
AFP regulator 1
alpha-fetoprotein regulator 1
regulator of AFP
transcription factor ZHX2
zinc finger and homeodomain protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046951.1 RefSeqGene

    Range
    5307..198167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001362797.1NP_001349726.1  zinc fingers and homeoboxes protein 2

    Status: REVIEWED

    Source sequence(s)
    AC016405, AC104316, AI334237, BC042145, BM148156, HY099683
    Consensus CDS
    CCDS6336.1
    Conserved Domains (2) summary
    smart00389
    Location:537582
    HOX; Homeodomain
    cd00086
    Location:444496
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. NM_014943.5NP_055758.1  zinc fingers and homeoboxes protein 2

    See identical proteins and their annotated locations for NP_055758.1

    Status: REVIEWED

    Source sequence(s)
    AC104316, BC042145, BM148156, HY099683
    Consensus CDS
    CCDS6336.1
    UniProtKB/Swiss-Prot
    Q9Y6X8
    Related
    ENSP00000314709.4, ENST00000314393.5
    Conserved Domains (2) summary
    smart00389
    Location:537582
    HOX; Homeodomain
    cd00086
    Location:444496
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    122781349..122974515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250837.4XP_005250894.1  zinc fingers and homeoboxes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y6X8
    Conserved Domains (2) summary
    smart00389
    Location:537582
    HOX; Homeodomain
    cd00086
    Location:444496
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. XM_011516932.3XP_011515234.1  zinc fingers and homeoboxes protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011515234.1

    UniProtKB/Swiss-Prot
    Q9Y6X8
    Conserved Domains (2) summary
    smart00389
    Location:537582
    HOX; Homeodomain
    cd00086
    Location:444496
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  3. XM_005250836.5XP_005250893.1  zinc fingers and homeoboxes protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005250893.1

    UniProtKB/Swiss-Prot
    Q9Y6X8
    Conserved Domains (2) summary
    smart00389
    Location:537582
    HOX; Homeodomain
    cd00086
    Location:444496
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
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