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FKBP3 FKBP prolyl isomerase 3 [ Homo sapiens (human) ]

Gene ID: 2287, updated on 9-Dec-2018

Summary

Official Symbol
FKBP3provided by HGNC
Official Full Name
FKBP prolyl isomerase 3provided by HGNC
Primary source
HGNC:HGNC:3719
See related
Ensembl:ENSG00000100442 MIM:186947
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKBP-3; FKBP25; PPIase; FKBP-25
Summary
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]
Expression
Ubiquitous expression in brain (RPKM 15.6), prostate (RPKM 14.4) and 25 other tissues See more
Orthologs

Genomic context

See FKBP3 in Genome Data Viewer
Location:
14q21.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (45115292..45134529, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (45584802..45603732, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370474 Neighboring gene pre-mRNA processing factor 39 Neighboring gene small nucleolar RNA, C/D box 127 Neighboring gene FA complementation group M Neighboring gene MIS18 binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FK506 binding TAS
Traceable Author Statement
more info
PubMed 
RNA binding HDA PubMed 
peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP3
Names
25 kDa FK506-binding protein
25 kDa FKBP
FK506 binding protein 3, 25kDa
FK506-binding protein 25, T-cell
FK506-binding protein 3
PPIase FKBP3
immunophilin FKBP25
rapamycin binding protein
rapamycin-selective 25 kDa immunophilin
rotamase
NP_002004.1
XP_011534867.1
XP_016876581.1
XP_016876582.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002013.4NP_002004.1  peptidyl-prolyl cis-trans isomerase FKBP3

    See identical proteins and their annotated locations for NP_002004.1

    Status: REVIEWED

    Source sequence(s)
    BC020809, BI598048, CN315192
    Consensus CDS
    CCDS9683.1
    UniProtKB/Swiss-Prot
    Q00688
    Related
    ENSP00000379374.3, ENST00000396062.3
    Conserved Domains (1) summary
    pfam00254
    Location:124221
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    45115292..45134529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536565.3XP_011534867.1  peptidyl-prolyl cis-trans isomerase FKBP3 isoform X3

    Conserved Domains (1) summary
    pfam00254
    Location:91188
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
  2. XM_017021092.2XP_016876581.1  peptidyl-prolyl cis-trans isomerase FKBP3 isoform X1

  3. XM_017021093.1XP_016876582.1  peptidyl-prolyl cis-trans isomerase FKBP3 isoform X2

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