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FKBP3 FKBP prolyl isomerase 3 [ Homo sapiens (human) ]

Gene ID: 2287, updated on 7-Jan-2024

Summary

Official Symbol
FKBP3provided by HGNC
Official Full Name
FKBP prolyl isomerase 3provided by HGNC
Primary source
HGNC:HGNC:3719
See related
Ensembl:ENSG00000100442 MIM:186947; AllianceGenome:HGNC:3719
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKBP-3; FKBP25; PPIase; FKBP-25
Summary
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]
Expression
Ubiquitous expression in brain (RPKM 15.6), prostate (RPKM 14.4) and 25 other tissues See more
Orthologs
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Genomic context

See FKBP3 in Genome Data Viewer
Location:
14q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (45115599..45134481, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (39307610..39327326, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (45584802..45603684, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD58 Neighboring gene pre-mRNA processing factor 39 Neighboring gene small nucleolar RNA, C/D box 127 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr14:45602882-45603753 and GRCh37_chr14:45603754-45604624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8301 Neighboring gene FA complementation group M Neighboring gene NANOG hESC enhancer GRCh37_chr14:45667610-45668129 Neighboring gene MIS18 binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:45720005-45720504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8303

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP3
Names
25 kDa FK506-binding protein
25 kDa FKBP
FK506 binding protein 3, 25kDa
FK506-binding protein 25, T-cell
FK506-binding protein 3
PPIase FKBP3
immunophilin FKBP25
rapamycin binding protein
rapamycin-selective 25 kDa immunophilin
rotamase
NP_002004.1
XP_011534867.1
XP_054231554.1
XP_054231555.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002013.4NP_002004.1  peptidyl-prolyl cis-trans isomerase FKBP3

    See identical proteins and their annotated locations for NP_002004.1

    Status: REVIEWED

    Source sequence(s)
    BC020809, BI598048, CN315192
    Consensus CDS
    CCDS9683.1
    UniProtKB/Swiss-Prot
    B2R4Q9, Q00688, Q14317
    UniProtKB/TrEMBL
    Q53GD8
    Related
    ENSP00000379374.3, ENST00000396062.4
    Conserved Domains (2) summary
    pfam00254
    Location:124221
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam18410
    Location:677
    BTHB; Basic tilted helix bundle domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    45115599..45134481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536565.4XP_011534867.1  peptidyl-prolyl cis-trans isomerase FKBP3 isoform X1

    UniProtKB/TrEMBL
    Q53GD8
    Conserved Domains (1) summary
    pfam00254
    Location:91188
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    39307610..39327326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375579.1XP_054231554.1  peptidyl-prolyl cis-trans isomerase FKBP3 isoform X2

    UniProtKB/Swiss-Prot
    B2R4Q9, Q00688, Q14317
    UniProtKB/TrEMBL
    Q53GD8
  2. XM_054375580.1XP_054231555.1  peptidyl-prolyl cis-trans isomerase FKBP3 isoform X1

    UniProtKB/TrEMBL
    Q53GD8