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ANKRD26 ankyrin repeat domain 26 [ Homo sapiens (human) ]

Gene ID: 22852, updated on 1-Aug-2020

Summary

Official Symbol
ANKRD26provided by HGNC
Official Full Name
ankyrin repeat domain 26provided by HGNC
Primary source
HGNC:HGNC:29186
See related
Ensembl:ENSG00000107890 MIM:610855
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
THC2; bA145E8.1
Summary
This gene encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions. Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are found on chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Broad expression in testis (RPKM 3.2), brain (RPKM 0.7) and 22 other tissues See more
Orthologs

Genomic context

See ANKRD26 in Genome Data Viewer
Location:
10p12.1
Exon count:
46
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (26938195..27100498, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (27284054..27389427, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene decaprenyl diphosphate synthase subunit 1 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 3 Neighboring gene abl interactor 1 Neighboring gene RNA, U6 small nuclear 946, pseudogene Neighboring gene family with sequence similarity 238 member C Neighboring gene RNA, U6 small nuclear 490, pseudogene Neighboring gene YME1 like 1 ATPase Neighboring gene microtubule associated serine/threonine kinase like Neighboring gene RNA, U2 small nuclear 24, pseudogene Neighboring gene acyl-CoA binding domain containing 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1074, MGC163325

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ankyrin repeat domain-containing protein 26
Names
GNS/ANKRD26/NCKAP1L fusion

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031973.2 RefSeqGene

    Range
    5001..101383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_605

mRNA and Protein(s)

  1. NM_001256053.2NP_001242982.1  ankyrin repeat domain-containing protein 26 isoform 2

    See identical proteins and their annotated locations for NP_001242982.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AB028997, AL162272
    UniProtKB/Swiss-Prot
    Q9UPS8
    Conserved Domains (7) summary
    COG0419
    Location:10671586
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00204
    Location:74199
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12001
    Location:15221630
    DUF3496; Domain of unknown function (DUF3496)
    pfam12796
    Location:84176
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:50100
    Ank_4; Ankyrin repeats (many copies)
    pfam14915
    Location:9131216
    CCDC144C; CCDC144C protein coiled-coil region
    sd00045
    Location:79110
    ANK; ANK repeat [structural motif]
  2. NM_014915.3NP_055730.2  ankyrin repeat domain-containing protein 26 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AB028997, AK001137, AL137351, CD626319, DA712092, DB228067
    Consensus CDS
    CCDS41499.1
    UniProtKB/Swiss-Prot
    Q9UPS8
    Related
    ENSP00000365255.4, ENST00000376087.4
    Conserved Domains (6) summary
    cd00204
    Location:74199
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:79110
    ANK; ANK repeat [structural motif]
    pfam12001
    Location:15231631
    DUF3496; Domain of unknown function (DUF3496)
    pfam14915
    Location:9141217
    CCDC144C; CCDC144C protein coiled-coil region
    cl25732
    Location:7541586
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26072
    Location:129282
    Ank_5; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    26938195..27100498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015929.1XP_016871418.1  ankyrin repeat domain-containing protein 26 isoform X2

  2. XM_017015928.1XP_016871417.1  ankyrin repeat domain-containing protein 26 isoform X1

  3. XM_017015930.1XP_016871419.1  ankyrin repeat domain-containing protein 26 isoform X4

    Conserved Domains (7) summary
    cd00204
    Location:74199
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12001
    Location:18851993
    DUF3496; Domain of unknown function (DUF3496)
    pfam12796
    Location:84176
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:50100
    Ank_4; Ankyrin repeats (many copies)
    pfam14915
    Location:12761579
    CCDC144C; CCDC144C protein coiled-coil region
    sd00045
    Location:79110
    ANK; ANK repeat [structural motif]
    cl02488
    Location:15441741
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  4. XM_017015931.1XP_016871420.1  ankyrin repeat domain-containing protein 26 isoform X4

    Conserved Domains (7) summary
    cd00204
    Location:74199
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12001
    Location:18851993
    DUF3496; Domain of unknown function (DUF3496)
    pfam12796
    Location:84176
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:50100
    Ank_4; Ankyrin repeats (many copies)
    pfam14915
    Location:12761579
    CCDC144C; CCDC144C protein coiled-coil region
    sd00045
    Location:79110
    ANK; ANK repeat [structural motif]
    cl02488
    Location:15441741
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  5. XM_011519416.2XP_011517718.1  ankyrin repeat domain-containing protein 26 isoform X4

    See identical proteins and their annotated locations for XP_011517718.1

    Conserved Domains (7) summary
    cd00204
    Location:74199
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12001
    Location:18851993
    DUF3496; Domain of unknown function (DUF3496)
    pfam12796
    Location:84176
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:50100
    Ank_4; Ankyrin repeats (many copies)
    pfam14915
    Location:12761579
    CCDC144C; CCDC144C protein coiled-coil region
    sd00045
    Location:79110
    ANK; ANK repeat [structural motif]
    cl02488
    Location:15441741
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  6. XM_017015932.1XP_016871421.1  ankyrin repeat domain-containing protein 26 isoform X5

    Conserved Domains (7) summary
    cd00204
    Location:74199
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12001
    Location:18851993
    DUF3496; Domain of unknown function (DUF3496)
    pfam12796
    Location:84176
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:50100
    Ank_4; Ankyrin repeats (many copies)
    pfam14915
    Location:12761579
    CCDC144C; CCDC144C protein coiled-coil region
    sd00045
    Location:79110
    ANK; ANK repeat [structural motif]
    cl02488
    Location:15441741
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  7. XM_006717425.4XP_006717488.1  ankyrin repeat domain-containing protein 26 isoform X5

    Conserved Domains (7) summary
    cd00204
    Location:74199
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12001
    Location:18851993
    DUF3496; Domain of unknown function (DUF3496)
    pfam12796
    Location:84176
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:50100
    Ank_4; Ankyrin repeats (many copies)
    pfam14915
    Location:12761579
    CCDC144C; CCDC144C protein coiled-coil region
    sd00045
    Location:79110
    ANK; ANK repeat [structural motif]
    cl02488
    Location:15441741
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  8. XM_006717423.2XP_006717486.1  ankyrin repeat domain-containing protein 26 isoform X3

    Conserved Domains (7) summary
    cd00204
    Location:74199
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12001
    Location:18851993
    DUF3496; Domain of unknown function (DUF3496)
    pfam12796
    Location:84176
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:50100
    Ank_4; Ankyrin repeats (many copies)
    pfam14915
    Location:12761579
    CCDC144C; CCDC144C protein coiled-coil region
    sd00045
    Location:79110
    ANK; ANK repeat [structural motif]
    cl02488
    Location:15441741
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  9. XM_017015933.1XP_016871422.1  ankyrin repeat domain-containing protein 26 isoform X6

    Conserved Domains (6) summary
    cd00204
    Location:74199
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:84176
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:50100
    Ank_4; Ankyrin repeats (many copies)
    pfam14915
    Location:12761579
    CCDC144C; CCDC144C protein coiled-coil region
    pfam17045
    Location:11261408
    CEP63; Centrosomal protein of 63 kDa
    sd00045
    Location:79110
    ANK; ANK repeat [structural motif]
  10. XM_024447896.1XP_024303664.1  ankyrin repeat domain-containing protein 26 isoform X7

    Conserved Domains (3) summary
    cd00204
    Location:74199
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:79110
    ANK; ANK repeat [structural motif]
    cl26072
    Location:129282
    Ank_5; Ankyrin repeats (many copies)
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