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CPEB3 cytoplasmic polyadenylation element binding protein 3 [ Homo sapiens (human) ]

Gene ID: 22849, updated on 11-Sep-2019

Summary

Official Symbol
CPEB3provided by HGNC
Official Full Name
cytoplasmic polyadenylation element binding protein 3provided by HGNC
Primary source
HGNC:HGNC:21746
See related
Ensembl:ENSG00000107864 MIM:610606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in brain (RPKM 4.8), liver (RPKM 4.1) and 25 other tissues See more
Orthologs

Genomic context

See CPEB3 in Genome Data Viewer
Location:
10q23.32
Exon count:
17
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (92046692..92291499, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (93806452..94050875, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9903 Neighboring gene fibroblast growth factor binding protein 3 Neighboring gene B-TFIID TATA-box binding protein associated factor 1 Neighboring gene uncharacterized LOC107984254 Neighboring gene succinate dehydrogenase complex subunit C pseudogene 2 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 8 Neighboring gene NHP2 ribonucleoprotein pseudogene 1 Neighboring gene membrane associated ring-CH-type finger 5 Neighboring gene RNY3 pseudogene 12 Neighboring gene microtubule affinity regulating kinase 2 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Dorso-ventral axis formation, organism-specific biosystem (from KEGG)
    Dorso-ventral axis formation, organism-specific biosystem
    Dorso-ventral axis formation
  • Dorso-ventral axis formation, conserved biosystem (from KEGG)
    Dorso-ventral axis formation, conserved biosystem
    Dorso-ventral axis formation
  • Oocyte meiosis, organism-specific biosystem (from KEGG)
    Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • Oocyte meiosis, conserved biosystem (from KEGG)
    Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
    Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
  • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
    Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA stem-loop binding ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA 3'-UTR AU-rich region binding ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-UTR binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation factor activity, RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation factor activity, RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
translation factor activity, RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
translation repressor activity, mRNA regulatory element binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation repressor activity, mRNA regulatory element binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
long-term memory ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cytoplasmic translational elongation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mRNA polyadenylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
CCR4-NOT complex IDA
Inferred from Direct Assay
more info
PubMed 
apical dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
messenger ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cytoplasmic polyadenylation element-binding protein 3
Names
CPE-BP3
CPE-binding protein 3
hCPEB-3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001178137.2NP_001171608.1  cytoplasmic polyadenylation element-binding protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001171608.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AB023157, AL365398, BC036444, BU785463, DA697430
    Consensus CDS
    CCDS53553.1
    UniProtKB/Swiss-Prot
    Q8NE35
    UniProtKB/TrEMBL
    Q5QP71
    Related
    ENSP00000398310.2, ENST00000412050.8
    Conserved Domains (4) summary
    COG0724
    Location:423589
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:427518
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:535615
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:610671
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  2. NM_014912.5NP_055727.3  cytoplasmic polyadenylation element-binding protein 3 isoform 1

    See identical proteins and their annotated locations for NP_055727.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AB023157, AK127060, AL365398, BC036444, BU785463
    Consensus CDS
    CCDS31246.1
    UniProtKB/Swiss-Prot
    Q8NE35
    UniProtKB/TrEMBL
    B3KXC1
    Related
    ENSP00000265997.4, ENST00000265997.5
    Conserved Domains (4) summary
    COG0724
    Location:437603
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:441532
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:549629
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:624685
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    92046692..92291499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539517.2XP_011537819.1  cytoplasmic polyadenylation element-binding protein 3 isoform X5

    Conserved Domains (4) summary
    COG0724
    Location:404570
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:408499
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:516596
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:591652
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  2. XM_011539520.2XP_011537822.1  cytoplasmic polyadenylation element-binding protein 3 isoform X8

    Conserved Domains (3) summary
    cd12726
    Location:449529
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:524585
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cl17169
    Location:386432
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_005269630.4XP_005269687.1  cytoplasmic polyadenylation element-binding protein 3 isoform X4

    See identical proteins and their annotated locations for XP_005269687.1

    UniProtKB/Swiss-Prot
    Q8NE35
    UniProtKB/TrEMBL
    Q5QP71
    Conserved Domains (4) summary
    COG0724
    Location:423589
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:427518
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:535615
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:610671
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  4. XM_011539515.2XP_011537817.1  cytoplasmic polyadenylation element-binding protein 3 isoform X3

    Conserved Domains (4) summary
    COG0724
    Location:431597
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:435526
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:543623
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:618679
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  5. XM_011539519.2XP_011537821.1  cytoplasmic polyadenylation element-binding protein 3 isoform X7

    Conserved Domains (3) summary
    cd12726
    Location:472552
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:547608
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cl17169
    Location:409455
    RRM_SF; RNA recognition motif (RRM) superfamily
  6. XM_006717715.3XP_006717778.1  cytoplasmic polyadenylation element-binding protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006717778.1

    Conserved Domains (3) summary
    cd12724
    Location:458549
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:566646
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:641702
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  7. XM_017015927.1XP_016871416.1  cytoplasmic polyadenylation element-binding protein 3 isoform X11

  8. XM_011539514.2XP_011537816.1  cytoplasmic polyadenylation element-binding protein 3 isoform X2

    Conserved Domains (4) summary
    COG0724
    Location:446612
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:450541
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:558638
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:633694
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  9. XM_024447895.1XP_024303663.1  cytoplasmic polyadenylation element-binding protein 3 isoform X1

    Conserved Domains (3) summary
    cd12724
    Location:458549
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:566646
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:641702
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  10. XM_006717714.3XP_006717777.1  cytoplasmic polyadenylation element-binding protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006717777.1

    Conserved Domains (3) summary
    cd12724
    Location:458549
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:566646
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:641702
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  11. XM_024447894.1XP_024303662.1  cytoplasmic polyadenylation element-binding protein 3 isoform X1

    Conserved Domains (3) summary
    cd12724
    Location:458549
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:566646
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:641702
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  12. XM_024447893.1XP_024303661.1  cytoplasmic polyadenylation element-binding protein 3 isoform X1

    Conserved Domains (3) summary
    cd12724
    Location:458549
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:566646
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:641702
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  13. XM_011539518.2XP_011537820.1  cytoplasmic polyadenylation element-binding protein 3 isoform X6

    Conserved Domains (3) summary
    COG0724
    Location:454620
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:458549
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:566640
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
  14. XM_011539523.2XP_011537825.1  cytoplasmic polyadenylation element-binding protein 3 isoform X10

  15. XM_011539522.2XP_011537824.1  cytoplasmic polyadenylation element-binding protein 3 isoform X9

RNA

  1. XR_001747064.1 RNA Sequence

  2. XR_001747063.1 RNA Sequence

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