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Nup214 nucleoporin 214 [ Mus musculus (house mouse) ]

Gene ID: 227720, updated on 9-Mar-2023

Summary

Official Symbol
Nup214provided by MGI
Official Full Name
nucleoporin 214provided by MGI
Primary source
MGI:MGI:1095411
See related
Ensembl:ENSMUSG00000001855 AllianceGenome:MGI:1095411
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAN; D2H9S46E
Summary
A structural constituent of nuclear pore. Acts upstream of or within mRNA export from nucleus; protein import into nucleus; and regulation of cell cycle. Predicted to be located in cytoplasmic side of nuclear pore. Predicted to be part of nuclear pore. Is expressed in future spinal cord; lung; and nervous system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; and brain disease. Orthologous to human NUP214 (nucleoporin 214). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 23.6), thymus adult (RPKM 16.1) and 28 other tissues See more
Orthologs
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Genomic context

See Nup214 in Genome Data Viewer
Location:
2 B; 2 21.97 cM
Exon count:
37
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (31863871..31943987)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (31974408..32053975)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene laminin gamma 3 Neighboring gene allograft inflammatory factor 1-like Neighboring gene BTG3 associated nuclear protein pseudogene Neighboring gene predicted gene 13609 Neighboring gene family with sequence similarity 78, member A Neighboring gene microRNA 7674 Neighboring gene predicted gene, 33126 Neighboring gene phospholipid phosphatase 7 (inactive)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC37347

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear export signal receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear localization sequence binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of nuclear pore IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of nucleocytoplasmic transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasmic side of nuclear pore ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nuclear pore NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nuclear pore complex protein Nup214
Names
214 kDa nucleoporin
nucleoporin Nup214

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408097.1NP_001395026.1  nuclear pore complex protein Nup214 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL928893
  2. NM_172268.3NP_758472.2  nuclear pore complex protein Nup214 isoform 1

    See identical proteins and their annotated locations for NP_758472.2

    Status: VALIDATED

    Source sequence(s)
    AL928893
    Consensus CDS
    CCDS38098.1
    UniProtKB/Swiss-Prot
    A2ATN2, Q80U93
    Related
    ENSMUSP00000066492.7, ENSMUST00000065398.13
    Conserved Domains (4) summary
    COG2319
    Location:23266
    WD40; WD40 repeat [General function prediction only]
    COG5651
    Location:17302073
    COG5651; PPE-repeat protein [Function unknown]
    sd00039
    Location:3986
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:94216
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    31863871..31943987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497945.5XP_006498008.1  nuclear pore complex protein Nup214 isoform X1

    Conserved Domains (8) summary
    PHA03247
    Location:428698
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:689880
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG2319
    Location:23266
    WD40; WD40 repeat [General function prediction only]
    COG5651
    Location:17842074
    COG5651; PPE-repeat protein [Function unknown]
    sd00039
    Location:3986
    7WD40; WD40 repeat [structural motif]
    pfam12894
    Location:155216
    ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
    pfam16768
    Location:17011859
    NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
    pfam18617
    Location:19121973
    Nup214_FG; Nucleoporin Nup214 phenylalanine-glycine (FG) domain
  2. XM_036160853.1XP_036016746.1  nuclear pore complex protein Nup214 isoform X2

    Conserved Domains (5) summary
    PHA03247
    Location:26296
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:287478
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15967
    Location:780965
    Nucleoporin_FG2; Nucleoporin FG repeated region
    pfam18617
    Location:15111571
    Nup214_FG; Nucleoporin Nup214 phenylalanine-glycine (FG) domain
    cl11081
    Location:13081564
    dermokine
  3. XM_017317376.2XP_017172865.1  nuclear pore complex protein Nup214 isoform X3

    Conserved Domains (3) summary
    PRK12799
    Location:126247
    motB; flagellar motor protein MotB; Reviewed
    PHA03247
    Location:138538
    PHA03247; large tegument protein UL36; Provisional
    pfam18617
    Location:838899
    Nup214_FG; Nucleoporin Nup214 phenylalanine-glycine (FG) domain