Tubb4b tubulin, beta 4B class IVB [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tubb4bprovided by MGI
Official Full Name: tubulin, beta 4B class IVBprovided by MGI
Primary source: MGI:MGI:1915472
See related: Ensembl:ENSMUSG00000036752 AllianceGenome:MGI:1915472
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tubb2c; Tubb2c1; 4930542G03Rik
Summary: Predicted to enable GTP binding activity and double-stranded RNA binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in flagellated sperm motility. Located in myelin sheath. Is active in sperm flagellum. Is expressed in brain ependyma; epithelial layer of oviduct; germ cell of testis; nasal epithelium; and respiratory system epithelium. Human ortholog(s) of this gene implicated in Leber congenital amaurosis with early-onset deafness. Orthologous to human TUBB4B (tubulin beta 4B class IVb). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 1044.7), liver E14 (RPKM 404.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 17.08 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (25112170..25114714, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (25222158..25224702, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TUBB4B is essential for the cytoskeletal architecture of cochlear supporting cells and motile cilia development.
Title: TUBB4B is essential for the cytoskeletal architecture of cochlear supporting cells and motile cilia development.
Tubb4b is required for multi-ciliogenesis in the mouse.
Title: Tubb4b is required for multi-ciliogenesis in the mouse.
[Expression of TUBB4B in mouse primary spermatocyte GC-2 cells and its regulatory effect on NF-kappaB and MAPK signaling pathway].
Title: [Expression of TUBB4B in mouse primary spermatocyte GC-2 cells and its regulatory effect on NF-κB and MAPK signaling pathway].
Tubulin TUBB4B Is Involved in Spermatogonia Proliferation and Cell Cycle Processes.
Title: Tubulin TUBB4B Is Involved in Spermatogonia Proliferation and Cell Cycle Processes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234342

SGC32809 (e-PCR)
- UniSTS:66491

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	NAS Non-traceable Author Statement more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in flagellated sperm motility	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based process	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axonemal microtubule	IEA Inferred from Electronic Annotation more info
located_in axonemal microtubule	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
is_active_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed
part_of tubulin complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: tubulin beta-4B chain

Names: novel tubulin protein; tubulin beta-2C chain; tubulin, beta 2C; tubulin, beta 2c1; tubulin, beta, 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.