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Tubb4b tubulin, beta 4B class IVB [ Mus musculus (house mouse) ]

Gene ID: 227613, updated on 11-Apr-2024

Summary

Official Symbol
Tubb4bprovided by MGI
Official Full Name
tubulin, beta 4B class IVBprovided by MGI
Primary source
MGI:MGI:1915472
See related
Ensembl:ENSMUSG00000036752 AllianceGenome:MGI:1915472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tubb2c; Tubb2c1; 4930542G03Rik
Summary
Predicted to enable GTP binding activity and double-stranded RNA binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in myelin sheath. Is expressed in brain ependyma; epithelial layer of oviduct; nasal epithelium; respiratory system epithelium; and seminiferous tubule. Human ortholog(s) of this gene implicated in Leber congenital amaurosis with early-onset deafness. Orthologous to human TUBB4B (tubulin beta 4B class IVb). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 1044.7), liver E14 (RPKM 404.4) and 28 other tissues See more
Orthologs
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Genomic context

Location:
2 A3; 2 17.08 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25112170..25114714, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25222158..25224702, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene negative elongation factor complex member B Neighboring gene predicted gene, 22572 Neighboring gene sperm tail PG rich repeat containing 3 Neighboring gene ciliary microtubule inner protein 2A Neighboring gene STARR-seq mESC enhancer starr_03963 Neighboring gene solute carrier family 34 (sodium phosphate), member 3 Neighboring gene ring finger protein 224

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC6713, MGC28623, MGC101937

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding NAS
Non-traceable Author Statement
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule-based process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in axonemal microtubule ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
part_of tubulin complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
tubulin beta-4B chain
Names
novel tubulin protein
tubulin beta-2C chain
tubulin, beta 2C
tubulin, beta 2c1
tubulin, beta, 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146116.2NP_666228.1  tubulin beta-4B chain

    See identical proteins and their annotated locations for NP_666228.1

    Status: VALIDATED

    Source sequence(s)
    AK167022, AL732309, CJ309661
    Consensus CDS
    CCDS15753.1
    UniProtKB/Swiss-Prot
    P68372, Q3TKF0, Q3UJ73, Q99JZ6
    UniProtKB/TrEMBL
    Q3U9U3
    Related
    ENSMUSP00000042342.5, ENSMUST00000043584.5
    Conserved Domains (1) summary
    PLN00220
    Location:1427
    PLN00220; tubulin beta chain; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25112170..25114714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)