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Ctdsp1 CTD small phosphatase 1 [ Mus musculus (house mouse) ]

Gene ID: 227292, updated on 30-Apr-2024

Summary

Official Symbol
Ctdsp1provided by MGI
Official Full Name
CTD small phosphatase 1provided by MGI
Primary source
MGI:MGI:2654470
See related
Ensembl:ENSMUSG00000026176 AllianceGenome:MGI:2654470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GIP; Nif3; SCP1; NLIIF
Summary
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cell differentiation; and negative regulation of protein phosphorylation. Predicted to be located in nucleoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and integumental system. Orthologous to human CTDSP1 (CTD small phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 92.4), lung adult (RPKM 83.8) and 28 other tissues See more
Orthologs
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Genomic context

See Ctdsp1 in Genome Data Viewer
Location:
1 C3; 1 38.54 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74430625..74436444)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74391609..74397285)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01333 Neighboring gene ciliogenesis associated TTC17 interacting protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:74433475-74433675 Neighboring gene solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 Neighboring gene STARR-positive B cell enhancer ABC_E2549 Neighboring gene STARR-seq mESC enhancer starr_01337 Neighboring gene predicted gene, 53562 Neighboring gene microRNA 26b Neighboring gene villin 1 Neighboring gene ubiquitin specific peptidase 37 Neighboring gene STARR-positive B cell enhancer mm9_chr1:74552349-74552650 Neighboring gene CCR4-NOT transcription complex, subunit 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Names
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
NLI-interacting factor 3
golli-interacting protein
nuclear LIM interactor-interacting factor 3
small C-terminal domain phosphatase 1
small CTD phosphatase 1
NP_001408190.1
NP_001408191.1
NP_001408192.1
NP_694728.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001421261.1NP_001408190.1  carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC098570
  2. NM_001421262.1NP_001408191.1  carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC098570
  3. NM_001421263.1NP_001408192.1  carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC098570
  4. NM_153088.3NP_694728.1  carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 2

    See identical proteins and their annotated locations for NP_694728.1

    Status: VALIDATED

    Source sequence(s)
    AC098570
    Consensus CDS
    CCDS15048.1
    UniProtKB/Swiss-Prot
    P58466
    UniProtKB/TrEMBL
    Q5I0X8
    Related
    ENSMUSP00000027367.8, ENSMUST00000027367.14
    Conserved Domains (1) summary
    TIGR02251
    Location:90249
    HIF-SF_euk; Dullard-like phosphatase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74430625..74436444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)